Evaluation of polysaccharide-based chiral stationary phases in quality control of (S)-mirtazapine

Biomedical Chromatography

Volumn 26, Issue 2, 2012, Pages 142-146

  Nageswara Rao, R ^a   Maurya, Pawan K ^a   Guruprasad, K ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Coated polysaccharides phases; Enantioseparation; Liquid chromatography; Mirtazapine; Quality control

Indexed keywords

CELLULOSE; CHROMATOGRAPHIC ANALYSIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

CHIRAL STATIONARY PHASE; CHIRALCEL OD-H; CHIRALPAK AD; COATED POLYSACCHARIDE PHASE; ENANTIOSEPARATIONS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHIC METHODS; MIRTAZAPINE; MOBILE-PHASE COMPOSITION; POLYSACCHARIDE-BASED CHIRAL STATIONARY PHASIS; RELATED SUBSTANCES;

QUALITY CONTROL;

ALCOHOL; AMYLOSE TRIS(3,5 DIMETHYLPHENYLCARBAMATE); CELLULOSE TRIS(3,5 DIMETHYLPHENYLCARBAMATE); CELLULOSE TRIS(4 METHYLBENZOATE); MIRTAZAPINE; POLYSACCHARIDE; UNCLASSIFIED DRUG;

ARTICLE; CHIRALITY; DRUG ISOLATION; DRUG QUALITY; DRUG STRUCTURE; ENANTIOMER; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; QUALITY CONTROL;

EID: 84855430678     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1638     Document Type: Article

References (17)

1. Aburatani R, Okamoto Y and Hatada K. Optical resolving ability of 3, 5-dimethylphenylcarbamates of oligosaccharides and cyclodextrins. Bulletin of the Chemical Society of Japan 1990; 63: 3606-3610.
2. Aturki Z, Scotti V, D'Orazio G, Rocco A, Raggi MA and Fanali S. Enantioselective separation of the novel antidepressant mirtazapine and its main metabolites by CEC. Electrophoresis 2007; 28: 2717-2725.
3. Davis R and Wilde MI. Mirtazapine: a review of its pharmacology and therapy potential in the management of major depression. CNS Drugs 1996; 5: 389-402.
4. Dodd S, Burrows GD and Norman TR. Chiral determination of mirtazapine in human blood plasma by high-performance liquid chromatography. Journal of Chromatography B: Biomedical Sciences and Applications 2000; 748: 439-443.
5. Fanali S, Aturki Z, Kasicka V, Raggi MA and D'Orazio G. Enantiomeric separation of mirtazapine and its metabolites by nano-liquid chromatography with UV-absorption and mass spectrometric detection. Journal of Separation Science 2005; 28: 1719-1728.
6. Holm KJ and Markham A. Mirtazapine - a review of its use in major depression. Drugs 1999; 57: 607-631.
7. Kelder J, Funke C, DeBoer T, Delbressine L, Leysen D and Nickolson V. A comparison of the physicochemical and biological properties of mirtazapine and mianserin. Journal of Pharmacy and Pharmacology 1997; 49: 403-411.
8. 3 receptors in cultured mouse neuroblastoma-cells. Neuropharmacology 1994; 33: 501-507.
9. Lanchote VL, Cesarino EJ, Jabor VAP, Malagueno de Santana FJ and Bonato PS. Enantioselective analysis of mirtazapine, demethylmirtazapine and 8-hydroxy mirtazapine in human urine after solid-phase microextraction. Journal of Separation Science 2010; 33: 268-276.
10. Mandrioli R, Pucci V, Sabbioni C, Bartoletti C, Fanali S and Raggi MA. Enantioselective determination of the novel antidepressant mirtazapine and its active demethylated metabolite in human plasma by means of capillary electrophoresis. Journal of Chromatography A 2004; 1051: 253-260.
11. Meineke I, Steinmetz H, Kirchheiner J and Brockmoeller J. Therapeutic drug monitoring of mirtazapine, desmethylmirtazapine, 8-hydroxymirtazapine, and mirtazapine-N-oxide by enantioselective HPLC with fluorescence detection. Therapeutic Drug Monitoring 2006; 28: 760-765.
12. Paus E, Jonzier-Perey M, Cochard N, Eap CB and Baumann P. Chirality in the new generation of antidepressants. Stereoselective analysis of the enantiomers of mirtazapine, N-desmethylmirtazapine and 8-hydroxymirtazapine by LC-MS. Therapeutic Drug Monitoring 2004; 26: 366-374.
13. Rao RN and Raju AN. Development and validation of a reversed-phase HPLC method for separation and simultaneous determination of process-related substances of mirtazapine in bulk drugs and formulations. Journal of Chromatographic Science 2009; 47: 223-230.
14. van der Linden M, Borsboom J, Kaspersen F and Kemperman G. Asymmetric synthesis of (S)-mirtazapine: Unexpected racemization through an aromatic ipso-attack mechanism. European Journal of Organic Chemistry 2008; 2989-2997.
15. Wang T and Wenslow RM. Effects of alcohol mobile-phase modifiers on the structure and chiral selectivity of amylose tris(3, 5-dimethylphenylcarbamate) chiral stationary phase. Journal of Chromatography A 2003; 1015: 99-110.
16. Zhai ZD, Shi YP and Wang T. Development and validation of HPLC methods for enantioseparation of mirtazapine enantiomers at analytical and semipreparative scale using polysaccharide chiral stationary phases. Analytica Chimica Acta 2005; 550: 123-129.
17. Zhang T, Nguyen D and Franco P. Enantiomer resolution screening strategy using multiple immobilised polysaccharide-based chiral stationary phases. Journal of Chromatography A 2008; 1191: 214-222.