메뉴 건너뛰기




Volumn 5, Issue 5, 1996, Pages 389-402

Mirtazapine: A Review of its Pharmacology and Therapeutic Potential in the Management of Major Depression

Author keywords

[No Author keywords available]

Indexed keywords

AMITRIPTYLINE; CLOMIPRAMINE; DOXEPIN; MIRTAZAPINE; TRAZODONE;

EID: 0029953756     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-199605050-00007     Document Type: Review
Times cited : (127)

References (49)
  • 1
    • 0029046156 scopus 로고
    • Mirtazapine: Clinical profile
    • Sitsen JMA, Zivkov M. Mirtazapine: clinical profile. CNS Drugs 1995; 4 Suppl. 1: 39-48
    • (1995) CNS Drugs , vol.4 , Issue.1 SUPPL. , pp. 39-48
    • Sitsen, J.M.A.1    Zivkov, M.2
  • 2
    • 0022618588 scopus 로고
    • Effect of chronic administration of the 6-aza analogue of mianserin (Org. 3770) and its enantiomers on behaviour and changes in noradrenaline metabolism of olfactory-bulbectomized rats in the 'open field' apparatus
    • O'Connor WT, Leonard BE. Effect of chronic administration of the 6-aza analogue of mianserin (Org. 3770) and its enantiomers on behaviour and changes in noradrenaline metabolism of olfactory-bulbectomized rats in the 'open field' apparatus. Neuropharmacology 1986 Mar; 25: 267-70
    • (1986) Neuropharmacology , vol.25 , pp. 267-270
    • O'Connor, W.T.1    Leonard, B.E.2
  • 3
    • 0028206054 scopus 로고
    • Effects of imipramine and mirtazapine on operant performance in rats
    • May
    • Andrews JS, Hansen JHM, Linders S, et al. Effects of imipramine and mirtazapine on operant performance in rats. Drug Dev Res 1994 May; 32: 58-66
    • (1994) Drug Dev Res , vol.32 , pp. 58-66
    • Andrews, J.S.1    Hansen, J.H.M.2    Linders, S.3
  • 4
    • 0025101885 scopus 로고
    • Antidepressant characteristics of Org 3770, Org 4428 and Org 9768 on rat sleep
    • Jul
    • Ruigt GSF, van Proosdij JN. Antidepressant characteristics of Org 3770, Org 4428 and Org 9768 on rat sleep [abstract]. Eur J Pharmacol 1990 Jul; 183: 1467-8
    • (1990) Eur J Pharmacol , vol.183 , pp. 1467-1468
    • Ruigt, G.S.F.1    Van Proosdij, J.N.2
  • 5
    • 0029056606 scopus 로고
    • 1A-mediated serotonergic neurotransmission
    • 1A-mediated serotonergic neurotransmission. CNS Drugs 1995; 4 Suppl. 1: 29-38
    • (1995) CNS Drugs , vol.4 , Issue.1 SUPPL. , pp. 29-38
    • De Boer, T.1    Ruigt, G.S.F.2
  • 6
    • 0023929271 scopus 로고
    • Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers
    • Apr
    • de Boer TH, Maura G, Raiteri M, et al. Neurochemical and autonomic pharmacological profiles of the 6-aza-analogue of mianserin, Org 3770 and its enantiomers. Neuropharmacology 1988 Apr; 27: 399-408
    • (1988) Neuropharmacology , vol.27 , pp. 399-408
    • De Boer, T.H.1    Maura, G.2    Raiteri, M.3
  • 7
    • 0028168404 scopus 로고
    • 1-Adrenoreceptor antagonists differentially control serotonin release in the hippocampus and striatum: A microdialysis study
    • 1-Adrenoreceptor antagonists differentially control serotonin release in the hippocampus and striatum: a microdialysis study. Eur J Pharmacol 1994; 261: 59-64
    • (1994) Eur J Pharmacol , vol.261 , pp. 59-64
    • Rouquier, L.1    Claustre, C.2    Benavides, J.3
  • 8
    • 0026684148 scopus 로고
    • The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry
    • Clement H-W, Gemsa D, Wesemann W. The effect of adrenergic drugs on serotonin metabolism in the nucleus raphe dorsalis of the rat, studied by in vivo voltammetry. Eur J Pharmacol 1992; 217: 43-8
    • (1992) Eur J Pharmacol , vol.217 , pp. 43-48
    • Clement, H.-W.1    Gemsa, D.2    Wesemann, W.3
  • 9
    • 0028181238 scopus 로고
    • 2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo
    • Feb
    • 2-adrenoceptor antagonist Org 3770 enhances serotonin transmission in vivo. Eur J Pharmacol 1994 Feb 21; 253: R5-6
    • (1994) Eur J Pharmacol , vol.253 , Issue.21
    • De Boer, T.1    Nefkens, F.2    Van Helvoirt, A.3
  • 10
    • 0023837235 scopus 로고
    • 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770
    • Jan-Feb
    • 2-adrenoceptor blockade in the central nervous system and the effects of the enantiomers of mianserin and its aza-analog ORG 3770. Arch Int Pharmacodyn Ther 1988 Jan-Feb; 291: 185-201
    • (1988) Arch Int Pharmacodyn Ther , vol.291 , pp. 185-201
    • Gower, A.J.1    Broekkamp, C.L.E.2    Rijk, H.W.3
  • 14
    • 0024471992 scopus 로고
    • Selective activation of 5-HT1A receptors induces lower lip retraction in the rat
    • Berendsen HHG, Jenck F, Broekkamp CLE. Selective activation of 5-HT1A receptors induces lower lip retraction in the rat. Pharmacol Biochem Behav 1989; 33: 821-7
    • (1989) Pharmacol Biochem Behav , vol.33 , pp. 821-827
    • Berendsen, H.H.G.1    Jenck, F.2    Broekkamp, C.L.E.3
  • 15
    • 0025173575 scopus 로고
    • Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice
    • Berendsen HHG, Broekkamp CLE. Behavioural evidence for functional interactions between 5-HT-receptor subtypes in rats and mice. Br J Pharmacol 1990; 101: 667-73
    • (1990) Br J Pharmacol , vol.101 , pp. 667-673
    • Berendsen, H.H.G.1    Broekkamp, C.L.E.2
  • 16
    • 0027446907 scopus 로고
    • In vivo electrophysiological evidence for tonic activation by endogeneous noradrenaline on α2-adrenergic heteroreceptors of 5-hydroxytryptamine terminals in the rat hippocampus
    • Mongeau R, Blier P, de Montigny C. In vivo electrophysiological evidence for tonic activation by endogeneous noradrenaline on α2-adrenergic heteroreceptors of 5-hydroxytryptamine terminals in the rat hippocampus. Naunyn Schmiedebergs Arch Pharmacol 1993; 347: 266-72
    • (1993) Naunyn Schmiedebergs Arch Pharmacol , vol.347 , pp. 266-272
    • Mongeau, R.1    Blier, P.2    De Montigny, C.3
  • 17
    • 0029070861 scopus 로고
    • The effects of mirtazapine on the interactions between central noradrenergic and serotonergic systems
    • de Montigny C, Haddjeri N, Mongeau R, et al. The effects of mirtazapine on the interactions between central noradrenergic and serotonergic systems. CNS Drugs 1995; 4 Suppl. 1: 13-7
    • (1995) CNS Drugs , vol.4 , Issue.1 SUPPL. , pp. 13-17
    • De Montigny, C.1    Haddjeri, N.2    Mongeau, R.3
  • 18
    • 0029079345 scopus 로고
    • Mechanisms of action of antidepressants
    • Leonard BE. Mechanisms of action of antidepressants. CNS Drugs 1995; 4 Suppl. 1: 1-12
    • (1995) CNS Drugs , vol.4 , Issue.1 SUPPL. , pp. 1-12
    • Leonard, B.E.1
  • 19
    • 0029028790 scopus 로고
    • Bioavailability of mirtazapine from Remeron (Rm) tablets after single and multiple oral dosing
    • Jul
    • Voortman G, Paanakker JE. Bioavailability of mirtazapine from Remeron (Rm) tablets after single and multiple oral dosing. Hum Psychopharmacol 1995 Jul: 10 Suppl. 2: S83-96
    • (1995) Hum Psychopharmacol , vol.10 , Issue.2 SUPPL.
    • Voortman, G.1    Paanakker, J.E.2
  • 20
    • 0029074770 scopus 로고
    • Pharmacokinetic dose-proportionality study at steady state of mirtazapine from Remeron (Rm) tablets
    • Jul
    • Timmer CJ, Lohmann AAM, Mink CPA. Pharmacokinetic dose-proportionality study at steady state of mirtazapine from Remeron (Rm) tablets. Hum Psychopharmacol 1995 Jul; 10 Suppl. 2: S97-106
    • (1995) Hum Psychopharmacol , vol.10 , Issue.2 SUPPL.
    • Timmer, C.J.1    Lohmann, A.A.M.2    Mink, C.P.A.3
  • 21
    • 0027448196 scopus 로고
    • Influence of hepatic impairment on the pharmacokinetics of single doses of mirtazapine in elderly subjects
    • Jan
    • Murdoch DL, Ashgar J, Ankier SI, et al. Influence of hepatic impairment on the pharmacokinetics of single doses of mirtazapine in elderly subjects [abstract]. Br J Clin Pharmacol 1943 Jan; 35: 76P
    • (1943) Br J Clin Pharmacol , vol.35
    • Murdoch, D.L.1    Ashgar, J.2    Ankier, S.I.3
  • 23
    • 0029150570 scopus 로고
    • Org 3770 (mirtazapine) versus trazodone: A placebo controlled trial in depressed elderly patients
    • Jul
    • Halikas JA. Org 3770 (mirtazapine) versus trazodone: a placebo controlled trial in depressed elderly patients. Hum Psychopharmacol 1995 Jul; 10 Suppl. 2: S125-33
    • (1995) Hum Psychopharmacol , vol.10 , Issue.2 SUPPL.
    • Halikas, J.A.1
  • 24
    • 0025082572 scopus 로고
    • Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder
    • Smith WT, Glaudin V, Panagides J, Mirtazapine vs. amitriptyline vs. placebo in the treatment of major depressive disorder. Psychopharmacol Bull 1490; 26 (2): 191-6
    • (1490) Psychopharmacol Bull , vol.26 , Issue.2 , pp. 191-196
    • Smith, W.T.1    Glaudin, V.2    Panagides, J.3
  • 25
    • 0029154366 scopus 로고
    • A randomised, double-blind, placebo-controlled, 5-weeks' study of Org 3770 (mirtazapine) in major depression
    • Jul
    • Khan MC. A randomised, double-blind, placebo-controlled, 5-weeks' study of Org 3770 (mirtazapine) in major depression. Hum Psychopharmacol 1995 Jul; 10 Suppl. 2: S119-24
    • (1995) Hum Psychopharmacol , vol.10 , Issue.2 SUPPL.
    • Khan, M.C.1
  • 26
    • 0029070521 scopus 로고
    • A double-blind placebo-controlled study of Org 3770 in depressed outpatients
    • Jun
    • Claghorn JL, Lesem MD. A double-blind placebo-controlled study of Org 3770 in depressed outpatients. J Affect Disord 1995 Jun 8; 34: 165-71
    • (1995) J Affect Disord , vol.34 , Issue.8 , pp. 165-171
    • Claghorn, J.L.1    Lesem, M.D.2
  • 27
    • 0028798939 scopus 로고
    • A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression
    • Bremner JD. A double-blind comparison of Org 3770, amitriptyline, and placebo in major depression. J Clin Psychiatry 1945; 56: 519-25
    • (1945) J Clin Psychiatry , vol.56 , pp. 519-525
    • Bremner, J.D.1
  • 28
    • 0028237797 scopus 로고
    • Double-blind study of mirtazapine and placebo in hospitalized patients with major depression
    • Jun
    • Vartiainen H, Leinonen K. Double-blind study of mirtazapine and placebo in hospitalized patients with major depression. Kur Neuropsychopharmacol 1994 Jun; 4: 145-50
    • (1994) Kur Neuropsychopharmacol , vol.4 , pp. 145-150
    • Vartiainen, H.1    Leinonen, K.2
  • 29
    • 0029562421 scopus 로고
    • Clinical efficacy of mirtazapine: A review of meta-analyses of pooled data
    • Kasper S. Clinical efficacy of mirtazapine: a review of meta-analyses of pooled data. Int Clin Psychopharmacol 1995; 10 Suppl. 4: 25-35
    • (1995) Int Clin Psychopharmacol , vol.10 , Issue.4 SUPPL. , pp. 25-35
    • Kasper, S.1
  • 30
    • 0029131786 scopus 로고
    • Efficacy of Org 3770 (mirtazapine) vs amitriptyline in patients with major depressive disorder: A meta-analysis
    • Jul
    • Zivkov M, Roes KCB, Pols AG. Efficacy of Org 3770 (mirtazapine) vs amitriptyline in patients with major depressive disorder: a meta-analysis. Hum Psychopharmacol 1995 Jul; 10 Suppl. 2: S135-45
    • (1995) Hum Psychopharmacol , vol.10 , Issue.2 SUPPL.
    • Zivkov, M.1    Roes, K.C.B.2    Pols, A.G.3
  • 31
    • 0029010292 scopus 로고
    • Org 3770 versus amitriptyline: A 6-week randomised double-blind multicentre trial in hospitalized depressed patients
    • May-Jun
    • Zivkov M, De Jongh GD. Org 3770 versus amitriptyline: a 6-week randomised double-blind multicentre trial in hospitalized depressed patients. Hum Psychopharmacol 1995 May-Jun; 10: 173-80
    • (1995) Hum Psychopharmacol , vol.10 , pp. 173-180
    • Zivkov, M.1    De Jongh, G.D.2
  • 32
    • 0029118693 scopus 로고
    • A multicentre, double-blind, clomipramine-controlled efficacy and safety study of Org 3770
    • Jul-Aug
    • Richou H, Ruimy P, Charbaut J, et al. A multicentre, double-blind, clomipramine-controlled efficacy and safety study of Org 3770. Hum Psychopharmacol 1995 Jul-Aug; 10: 263-71
    • (1995) Hum Psychopharmacol , vol.10 , pp. 263-271
    • Richou, H.1    Ruimy, P.2    Charbaut, J.3
  • 33
    • 0028792322 scopus 로고
    • A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression
    • Marttila M, Jääskeläinen J, Järvi R, et al. A double-blind study comparing the efficacy and tolerability of mirtazapine and doxepin in patients with major depression. Eur Neuropsychopharmacol 1945; 5: 441-6
    • (1945) Eur Neuropsychopharmacol , vol.5 , pp. 441-446
    • Marttila, M.1    Jääskeläinen, J.2    Järvi, R.3
  • 34
    • 0028908269 scopus 로고
    • Mirtazapine is more effective than trazodone: A double-blind controlled study in hospitalized patients with major depression
    • Mar
    • van Moffaert M, de Wilde J, Vereecken A, et al. Mirtazapine is more effective than trazodone: a double-blind controlled study in hospitalized patients with major depression. Int Clin Psychopharmacol 1995 Mar; 10: 3-9
    • (1995) Int Clin Psychopharmacol , vol.10 , pp. 3-9
    • Van Moffaert, M.1    De Wilde, J.2    Vereecken, A.3
  • 35
    • 0029586363 scopus 로고
    • Safery of mirtazapine: A review
    • Montgomery SA. Safery of mirtazapine: a review. Int Clin Psychopharmacol 1995; 10 Suppl. 4: 37-45
    • (1995) Int Clin Psychopharmacol , vol.10 , Issue.4 SUPPL. , pp. 37-45
    • Montgomery, S.A.1
  • 36
    • 0013469551 scopus 로고
    • Organon Remeron is first alpla-2 receptor antagonist antidepressant recommended by advisory committee; labeling should note neutropenia risk
    • Oct
    • Organon Remeron is first alpla-2 receptor antagonist antidepressant recommended by advisory committee; labeling should note neutropenia risk. FDC Rep Pink Sheet 1995 Oct; 23: 16
    • (1995) FDC Rep Pink Sheet , vol.23 , pp. 16
  • 37
    • 1842502264 scopus 로고
    • FDA panel clears Organon's Remeron
    • Oct
    • FDA panel clears Organon's Remeron. Scrip 1995 Oct 24; 2071: 20
    • (1995) Scrip , vol.2071 , Issue.24 , pp. 20
  • 39
    • 0024407098 scopus 로고
    • Actions and interactions of psychotropic drugs on human performance and mood: Single doses of ORG 3770, amitriptyline, and diazepam
    • Aug
    • Mattila M, Mattila MJ, Vrijmoed-de Vries M, et al. Actions and interactions of psychotropic drugs on human performance and mood: single doses of ORG 3770, amitriptyline, and diazepam. Pharmacol Toxicol 1989 Aug; 65: 81-8
    • (1989) Pharmacol Toxicol , vol.65 , pp. 81-88
    • Mattila, M.1    Mattila, M.J.2    Vrijmoed-de Vries, M.3
  • 40
    • 1842606751 scopus 로고
    • WHO Collaborative Study on Psychological Problems in General Health Care: Hidden burden of mental illness uncovered by World Health Organisation study
    • Langsdale T. WHO Collaborative Study on Psychological Problems in General Health Care: hidden burden of mental illness uncovered by World Health Organisation study. Pharmaco-resources 1995; 26: 9
    • (1995) Pharmaco-resources , vol.26 , pp. 9
    • Langsdale, T.1
  • 41
    • 0026310589 scopus 로고
    • Does treatment with antidepressant medication increase suicidal behavior?
    • Goldblatt MJ, Schatzberg AF. Does treatment with antidepressant medication increase suicidal behavior? Int Clin Psychopharmacol 1991; 6: 219-26
    • (1991) Int Clin Psychopharmacol , vol.6 , pp. 219-226
    • Goldblatt, M.J.1    Schatzberg, A.F.2
  • 42
  • 43
    • 0024230596 scopus 로고
    • The long-term outcome of depressive illness
    • Kiloh LG, Andrews G, Neilson M. The long-term outcome of depressive illness. Br J Psychiatry 1989; 153: 752-7
    • (1989) Br J Psychiatry , vol.153 , pp. 752-757
    • Kiloh, L.G.1    Andrews, G.2    Neilson, M.3
  • 44
    • 0024264115 scopus 로고
    • The long-term outcome of Maudsley depressives
    • Lee AS, Murray RM. The long-term outcome of Maudsley depressives. Br J Psychiatry 1991; 153: 741-51
    • (1991) Br J Psychiatry , vol.153 , pp. 741-751
    • Lee, A.S.1    Murray, R.M.2
  • 45
    • 0026769806 scopus 로고
    • Epidemiology of depression in primary care
    • Katon W, Schulberg H. Epidemiology of depression in primary care. Gen Hosp Psychiatry 1992; 14: 237-47
    • (1992) Gen Hosp Psychiatry , vol.14 , pp. 237-247
    • Katon, W.1    Schulberg, H.2
  • 46
    • 0026719236 scopus 로고
    • The development of clinical practice guidelines for the diagnosis and treatment of depression
    • Rush AJ, Trivedi M, Schriger D, et al. The development of clinical practice guidelines for the diagnosis and treatment of depression. Gen Hosp Psychiatry 1992; 14: 230-6
    • (1992) Gen Hosp Psychiatry , vol.14 , pp. 230-236
    • Rush, A.J.1    Trivedi, M.2    Schriger, D.3
  • 47
    • 0028272935 scopus 로고
    • Use of minor tranquilizers and antidepressant medications by depressed outpatients: Results from the Medical Outcomes Study
    • Wells KB, Katon W, Rogers B, et al. Use of minor tranquilizers and antidepressant medications by depressed outpatients: results from the Medical Outcomes Study. Am J Psychiatry 1994; 151: 694-700
    • (1994) Am J Psychiatry , vol.151 , pp. 694-700
    • Wells, K.B.1    Katon, W.2    Rogers, B.3
  • 48
    • 0028913234 scopus 로고
    • The clinical and financial burden of mood disorders: Cost and outcome
    • Hall RCW, Wise MG. The clinical and financial burden of mood disorders: cost and outcome. Psychosomatics 1995; 36 Suppl.: S11-8
    • (1995) Psychosomatics , vol.36 , Issue.SUPPL.
    • Hall, R.C.W.1    Wise, M.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.