Direct detection by real-time PCR of ftsI gene mutations affecting MICs of β-lactam agents for Haemophilus influenzae isolates from meningitis

Journal of Infection and Chemotherapy

Volumn 17, Issue 5, 2011, Pages 671-677

  Kishii, Kozue ^a,b   Morozumi, Miyuki ^a,b   Chiba, Naoko ^a,b   Ono, Akiko ^a,b   Ubukata, Kimiko ^a  

^a KITASATO UNIVERSITY   (Japan)

^b MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

Haemophilus influenzae; Penicillin binding protein 3; Rapid real time PCR

Indexed keywords

AMPICILLIN; BETA LACTAM ANTIBIOTIC; CEFDITOREN; CEFOTAXIME; CEFTRIAXONE; CEPHALOSPORIN DERIVATIVE; MEROPENEM; TEBIPENEM;

16S RIBOSOMAL RNA GENE; AMINO ACID SUBSTITUTION; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; BLATEM GENE; CAP GENE; CHILD; CONTROLLED STUDY; FTSI GENE; GENE MUTATION; GENE SEQUENCE; HAEMOPHILUS INFLUENZAE; HAEMOPHILUS MENINGITIS; HUMAN; INFANT; INTERMETHOD COMPARISON; MALE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; POLYMERASE CHAIN REACTION; REAL TIME POLYMERASE CHAIN REACTION; SCHOOL CHILD; SENSITIVITY AND SPECIFICITY;

EID: 84855427249     PISSN: 1341321X     EISSN: 14377780     Source Type: Journal    
DOI: 10.1007/s10156-011-0256-8     Document Type: Article

References (22)

1. García-Cobos S, Campos J, Lázaro E, Román F, Cercenado E, García-Rey C, et al. Ampicillin-resistant non-b-lactamase-producing Haemophilus influenzae in Spain: Recent emergence of clonal isolates with increased resistance to cefotaxime and cefixime. Antimicrob Agents Chemother. 2007;51:2564-73. (Pubitemid 47047338)
2. Pérez-Trallero E, García-de-la-Fuente C, García-Rey C, Baquero F, Aguilar L, Dal-Ré R, et al. Geographical and ecological analysis of resistance, co-resistance, and coupled resistance to antimicrobials in respiratory pathogenic bacteria in Spain. Antimicrob Agents Chemother. 2005;49:1965-72. (Pubitemid 40631613)
3. Jansen WTM, Verel A, Beitsma M, Verhoef J, Milatovic D. Longitudinal European surveillance study of antibiotic resistance of Haemophilus influenzae. J Antimicrob Chemother. 2006;58:873-7. (Pubitemid 44390970)
4. Karlowsky JA, Verma G, Zhanel GG, Hoban DJ. Presence of ROB-1 β-lactamase correlates with cefaclor resistance among recent isolates of Haemophilus influenzae. J Antimicrob Chemother. 2000;45:871-5. (Pubitemid 30348959)
5. Medeiros AA, Levesque R, Jacoby GA. An animal source for the ROB-1 beta-lactamase of Haemophilus influenzae type b. Antimicrob Agents Chemother. 1986;29:212-5. (Pubitemid 16162927)
6. Scriver SR, Walmsley SL, Kau CL, Hoban DJ, Brunton J, McGeer A, et al. Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their beta-lactamases. Canadian Haemophilus Study Group. Antimicrob Agents Chemother. 1994;38:1678-80. (Pubitemid 24203593)
7. Vega R, Sadoff HL, Patterson MJ. Mechanisms of ampicillin resistance in Haemophilus influenzae type B. Antimicrob Agents Chemother. 1976;9:164-8.
8. Ubukata K, Shibasaki Y, Yamamoto K, Chiba N, Hasegawa K, Takeuchi Y, et al. Association of amino acid substitutions in penicillin-binding protein 3 with b-lactam resistance in b-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob Agents Chemother. 2001;45:1693-9. (Pubitemid 32466336)
9. Dabernat H, Delmas C, Seguy M, Pelissier R, Faucon G, Bennamani S, et al. Diversity of b-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae. Antimicrob Agents Chemother. 2002;46:2208-18. (Pubitemid 34665918)
10. Hasegawa K, Yamamoto K, Chiba N, Kobayashi R, Nagai K, Jacobs MR, et al. Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States. Microbial Drug Resist. 2003;9:39-46. (Pubitemid 36403057)
11. Osaki Y, Sanbongi Y, Ishikawa M, Osaki Y, Kataoka H, Suzuki T, et al. Genetic approach to study the relationship between penicillin-binding protein 3 mutations and Haemophilus influenzae β-lactam resistance by using site-directed mutagenesis and gene recombinants. Antimicrob Agents Chemother. 2005;49:2834-9. (Pubitemid 40917599)
12. Straker K, Wootton M, Simm AM, Bennett PM, MacGowan AP, Walsh TR. Cefuroxime resistance in non-β-lactamase Haemophilus influenzae is linked to mutations in ftsI. J Antimicrob Chemother. 2003;51:523-30. (Pubitemid 36336144)
13. Ubukata K, Asahi Y, Yamane A, Konno M. Combinational detection of autolysin and penicillin-binding protein 2B genes of Streptococcus pneumoniae by PCR. J Clin Microbiol. 1996;34:592-6. (Pubitemid 26065782)
14. Nelson MB, Apicella MA, Murphy TF, Vankeulen H, Spotila LD, Rekosh D. Cloning and sequencing of Haemophilus influenzae outer membrane protein P6. Infect Immun. 1988;56:128-34. (Pubitemid 18032141)
15. Sutcliffe J. G. Nucleotide sequence of the ampicillin resistance gene of Escherichia coli plasmid pBR322. Proc Natl Acad Sci USA. 1978;75:3737-41. (Pubitemid 8399275)
16. Juteau JM, Levesque RC. Sequence analysis and evolutionary perspectives of ROB-1 beta-lactamase. Antimicrob Agents Chemother. 1990;34:1354-9. (Pubitemid 20215773)
17. Fleischmann RD, Adams MD, White O, Clayton RA, Kirkness EF, Kerlavage AR, et al. Whole-genome random sequencing and assembly of Haemophilus influenzae Rd. Science. 1995;269: 496-512.
18. Van Eldere J, Brophy L, Loynds B, Celis P, Hancock I, Carman S, et al. Region II of the Haemophilus influenzae type b capsulation locus is involved in serotype-specific polysaccharide synthesis. Mol Microbiol. 1995;15:107-18.
19. Hasegawa K, Chiba N, Kobayashi R, Murayama SY, Iwata S, Sunakawa K, et al. Rapidly increasing prevalence of b-lactamasenonproducing, ampicillin-resistant Haemophilus influenzae type b in patients with meningitis. Antimicrob Agents Chemother. 2004;48:1509-14. (Pubitemid 38544352)
20. Hasegawa K, Kobayashi R, Takada E, Ono A, Chiba N, Morozumi M, et al. High prevalence of type b b-lactamase-nonproducing ampicillin-resistant Haemophilus influenzae in meningitis: The situation in Japan where Hib vaccine has not been introduced. J Antimicrob Chemother. 2006;57:1077-82. (Pubitemid 44644408)
21. Kishii K, Chiba N, Morozumi M, Hamano-Hasegawa K, Kurokawa I, Masaki J, et al. Diverse mutations in the ftsI gene in ampicillin-resistant Haemophilus influenzae isolates from pediatric patients with acute otitis media. J Infect Chemother. 2010;16:87-93.
22. Chiba N, Murayama SY, Morozumi M, Nakayama E, Okada T, Iwata S, et al. Rapid detection of eight causative pathogens for the diagnosis of bacterial meningitis by real-time PCR. J Infect Chemother. 2009;15:92-8.