Genetic approach to study the relationship between penicillin-binding protein 3 mutations and Haemophilus influenzae β-lactam resistance by using site-directed mutagenesis and gene recombinants

Antimicrobial Agents and Chemotherapy

Volumn 49, Issue 7, 2005, Pages 2834-2839

  Osaki, Yumi ^a   Sanbongi, Yumiko ^a   Ishikawa, Midori ^a   Kataoka, Hiroshi ^a   Suzuki, Takahisa ^a   Maeda, Kumiko ^a   Ida, Takashi ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AMPICILLIN; ASPARAGINE; BETA LACTAM; BETA LACTAM ANTIBIOTIC; BETA LACTAMASE; CARBAPENEM DERIVATIVE; CEFACLOR; CEFCAPENE; CEFDINIR; CEFDITOREN; CEFOTAXIME; CEFOZOPRAN; CEFPODOXIME; CEPHALOSPORIN DERIVATIVE; IMIPENEM; ISOLEUCINE; LEUCINE; MEROPENEM; METHIONINE; PENICILLIN BINDING PROTEIN; PENICILLIN BINDING PROTEIN 3; PENICILLIN G; PHENYLALANINE; THREONINE; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; FTSI GENE; GENE MUTATION; GENETIC ANALYSIS; GENETIC RECOMBINATION; HAEMOPHILUS INFLUENZAE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; NUCLEOTIDE SEQUENCE; PENICILLIN RESISTANCE; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANTI-BACTERIAL AGENTS; BACTERIAL PROTEINS; BETA-LACTAM RESISTANCE; BETA-LACTAMS; CEPHALOSPORINS; ESCHERICHIA COLI PROTEINS; HAEMOPHILUS INFLUENZAE; HUMANS; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PENICILLIN-BINDING PROTEINS; PEPTIDOGLYCAN GLYCOSYLTRANSFERASE; RECOMBINATION, GENETIC;

EID: 21444442865     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.49.7.2834-2839.2005     Document Type: Article

References (12)

1. Dabernat, H., C. Delmas, M. Seguy, R. Pelissier, G. Faucon, S. Bennamani, and C. Pasquier. 2002. Diversity of beta-lactam resistance-conferring amino acid substitutions in penicillin-binding protein 3 of Haemophilus influenzae. Antimicrob. Agents Chemother. 46:2208-2218.
2. Hasegawa, K., K. Yamamoto, N. Chiba, R. Kobayashi, K. Nagai, M. R. Jacobs, P. C. Appelbaum, K. Sunakawa, and K. Ubukata. 2003. Diversity of ampicillin-resistance genes in Haemophilus influenzae in Japan and the United States. Microb. Drug Resist. 9:39-46.
3. Kaczmarek, F. S., T. D. Gootz, F. Dib-Hajj, W. Shang, S. Hallowell, and M. Cronan. 2004. Genetic and molecular characterization of β-lactamase- negative ampicillin-resistant Haemophilus influenzae with unusually high resistance to ampicillin. Antimicrob. Agents Chemother. 48:1630-1639.
4. Konno, M., K. Ubukata, N. Chiba, K. Hasegawa, Y. Shibasaki, K. Sudo, K. Kishibe, H. Hujikawa, M. Sakai, Y. Koyama, M. Yokota, and T. Mayama. 2001. Postmarketing special investigation and its verification of precision for cefditoren pivoxil. Jpn. J. Chemother. 49:369-396. (In Japanese.)
5. Matic, V., B. Bozdogan, M. R. Jacobs, K. Ubukata, and P. C. Appelbaum. 2003. Contribution of β-lactamase and PBP amino acid substitutions to amoxicillin/clavulanate resistance in β-lactamases-positive, amoxicillin/clavulanate-resistant Haemophilus influenzae. J. Antimicrob. Chemother. 52:1018-1021.
6. National Committee for Clinical Laboratory Standards. 2002. Methods for dilution antimicrobial susceptibility for bacteria that grow aerobically; approved standard, 5th ed. NCCLS document M7-A5, vol. 20, no. 2. National Committee for Clinical Laboratory Standards, Wayne, Pa.
7. Scriver, S. R., S. L. Walmsley, C. L. Kau, D. J. Hoban, J. Brunton, A. McGeer, T. C. Moore, E. Witwicki, the Canadian Haemophilus Study Group, and D. E. Low. 1994. Determination of antimicrobial susceptibilities of Canadian isolates of Haemophilus influenzae and characterization of their β-lactamases. Antimicrob. Agents Chemother. 38:1678-1680.
8. Straker, K., M. Wootton, A. M. Simm, P. M. Bennett, A. P. MacGowan, and T. R. Walsh. 2003. Cefuroxime resistance in non-beta-lactamase Haemophilus influenzae is linked to mutations in ftsI. J. Antimicrob. Chemother. 51:523-530.
9. Suzuki, K., T. Nishimura, and S. Baba. 2003. Current status of bacterial resistance in the otolaryngology field: results from the second nationwide survey in Japan. J. Infect. Chemother. 9:46-62.
10. Ubukata, K. 2003. Problems associated with high prevalence of multidrug-resistant bacteria in patients with community-acquired infections. J. Infect. Chemother. 9:285-291.
11. Ubukata, K., Y. Shibasaki, K. Yamamoto, N. Chiba, K. Hasegawa, Y. Takeuchi, K. Sunakawa, M. Inoue, and M. Konno. 2001. Association of amino acid substitutions in penicillin-binding protein 3 with β-lactam resistance in β-lactamase-negative ampicillin-resistant Haemophilus influenzae. Antimicrob. Agents Chemother. 45:1693-1699.
12. Yoshida, I., G. Sugimori, I. Higashiyama, Y. Kimura, and Y. Yamano. 2003. Surveillance of susceptibility of clinical isolates of various bacterial species to antibacterial agents. Jpn. J. Chemother. 51:209-232. (In Japanese.)