New antimalarial indolone-N-oxides, generating radical species, destabilize the host cell membrane at early stages of Plasmodium falciparum growth: Role of band 3 tyrosine phosphorylation

Free Radical Biology and Medicine

Volumn 52, Issue 2, 2012, Pages 527-536

  Pantaleo, Antonella ^a   Ferru, Emanuela ^b   Vono, Rosa ^b   Giribaldi, Giuliana ^b   Lobina, Omar ^b   Nepveu, Françoise ^c   Ibrahim, Hany ^c   Nallet, Jean Pierre ^d   Carta, Franco ^e   Mannu, Franca ^e   Pippia, Proto ^a   Campanella, Estela ^f   Low, Philip S ^f   Turrini, Francesco ^b  

^a UNIVERSITY OF SASSARI   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

^c Hôpital Purpan   (France)

^d IDEALP PHARMA   (France)

^e Nurex SRL   (Italy)

^f PURDUE UNIVERSITY   (United States)

Author keywords

Band 3; Free radicals; Oxidative damage; Plasmodium falciparum; Red blood cells; Tyrosine phosphorylation

Indexed keywords

ANTIMALARIAL AGENT; ERYTHROCYTE BAND 3 PROTEIN; FREE RADICAL; HEMOGLOBIN; INDOLONE N OXIDE; PROTEIN KINASE SYK; PROTEIN KINASE SYK INHIBITOR; TYROSINE; UNCLASSIFIED DRUG;

ADULT; ANTIMALARIAL ACTIVITY; ARTICLE; CELL DAMAGE; CONTROLLED STUDY; CYTOSKELETON; ERYTHROCYTE; ERYTHROCYTE MEMBRANE; FEMALE; HOST CELL; HUMAN; HUMAN CELL; IC 50; MALE; MICROBIAL GROWTH; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEOMICS;

ANION EXCHANGE PROTEIN 1, ERYTHROCYTE; ANTIMALARIALS; CELL MEMBRANE; CYCLIC N-OXIDES; ERYTHROCYTES; FEMALE; FREE RADICALS; HUMANS; INDOLES; MALARIA, FALCIPARUM; MALE; MEMBRANE PROTEINS; PHOSPHORYLATION; PHOSPHOTYROSINE; PLASMODIUM FALCIPARUM; PROTEIN MULTIMERIZATION; PROTEOME;

PLASMODIUM FALCIPARUM;

EID: 84855421538     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2011.11.008     Document Type: Article

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