Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer

PLoS ONE

Volumn 7, Issue 1, 2012, Pages

  Zhao, Huajun ^a   Ho, Po Chun ^a   Lo, Yuan Hung ^a   Espejo, Alexsandra ^b   Bedford, Mark T ^b   Hung, Mien Chie ^c,d   Wang, Shao Chun ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS   (United States)

^c UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ABELSON KINASE; CYCLINE; DNA; TYROSINE; PEPTIDE FRAGMENT;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER GROWTH; CANCER INHIBITION; CELL MEMBRANE PERMEABILITY; CELL NUCLEUS; CELL PROLIFERATION; CELL STRESS; CHROMATIN; CONTROLLED STUDY; DNA DAMAGE; HUMAN; HUMAN CELL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; BREAST TUMOR; CARCINOMA; CELL STRAIN HEK293; CHEMISTRY; DRUG EFFECT; FEMALE; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; PHYSIOLOGY; PROTEIN BINDING; TUMOR CELL LINE;

BREAST NEOPLASMS; CARCINOMA; CELL LINE, TUMOR; CELL PROLIFERATION; CHROMATIN; DNA DAMAGE; FEMALE; HEK293 CELLS; HUMANS; PEPTIDE FRAGMENTS; PHOSPHORYLATION; PROLIFERATING CELL NUCLEAR ANTIGEN; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-ABL;

EID: 84855415190     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029416     Document Type: Article

References (23)

1. Taagepera S, McDonald D, Loeb JE, Whitaker LL, McElroy AK, et al. (1998) Nuclear-cytoplasmic shuttling of c-ABL tyrosine kinase. Proc Natl Acad Sci U S A 95: 7457-7462.
2. Lin J, Arlinghaus R, (2008) Activated c-Abl tyrosine kinase in malignant solid tumors. Oncogene 27: 4385-4391.
3. Lin J, Sun T, Ji L, Deng W, Roth J, et al. (2007) Oncogenic activation of c-Abl in non-small cell lung cancer cells lacking FUS1 expression: inhibition of c-Abl by the tumor suppressor gene product Fus1. Oncogene 26: 6989-6996.
4. Srinivasan D, Plattner R, (2006) Activation of Abl tyrosine kinases promotes invasion of aggressive breast cancer cells. Cancer Res 66: 5648-5655.
5. Srinivasan D, Sims JT, Plattner R, (2008) Aggressive breast cancer cells are dependent on activated Abl kinases for proliferation, anchorage-independent growth and survival. Oncogene 27: 1095-1105.
6. Sirvent A, Boureux A, Simon V, Leroy C, Roche S, (2007) The tyrosine kinase Abl is required for Src-transforming activity in mouse fibroblasts and human breast cancer cells. Oncogene 26: 7313-7323.
7. Zhao H, Ou-Yang F, Chen IF, Hou MF, Yuan SS, et al. (2010) Enhanced Resistance to Tamoxifen by the c-ABL Proto-oncogene in Breast Cancer. Neoplasia 12: 214-223.
8. Moldovan GL, Pfander B, Jentsch S, (2007) PCNA, the Maestro of the Replication Fork. Cell 129: 665-679.
9. Ayyagari R, Impellizzeri KJ, Yoder BL, Gary SL, Burgers PM, (1995) A mutational analysis of the yeast proliferating cell nuclear antigen indicates distinct roles in DNA replication and DNA repair. Mol Cell Biol 15: 4420-4429.
10. Lehmann AR, (2006) Translesion synthesis in mammalian cells. Exp Cell Res 312: 2673-2676.
11. Essers J, Theil AF, Baldeyron C, van Cappellen WA, Houtsmuller AB, (2005) Nuclear dynamics of PCNA in DNA replication and repair. Mol Cell Biol 25: 9350-9359.
12. Ulrich HD, (2004) How to activate a damage-tolerant polymerase: consequences of PCNA modifications by ubiquitin and SUMO. Cell Cycle 3: 15-8.
13. Maga G, Hubscher U, (2003) Proliferating cell nuclear antigen (PCNA): a dancer with many partners. J Cell Sci 116: 3051-3060.
14. Matunis MJ, (2002) On the Road to Repair: PCNA Encounters SUMO and Ubiquitin Modifications. Mol Cell 10: 441-442.
15. Marti TM, Kunz C, Fleck O, (2002) DNA mismatch repair and mutation avoidance pathways. J Cell Physiol 191: 28-41.
16. Paunesku T, Mittal S, Protić M, Oryhon J, Korolev SV, et al. (2001) Proliferating cell nuclear antigen (PCNA): ringmaster of the genome. Int J Radiat Biol 77: 1007-1021.
17. Kelman Z, (1997) PCNA: structure, functions and interactions. Oncogene 14: 629-640.
18. Komatsu K, Wharton W, Hang H, Wu C, Singh S, et al. (2000) PCNA interacts with hHus1/hRad9 in response to DNA damage and replication inhibition. Oncogene 19: 5291-5297.
19. Bravo R, Macdonald-Bravo H, (1987) Existence of two populations of cyclin/proliferating cell nuclear antigen during the cell cycle: association with DNA replication sites. J Cell Biol 105: 1549-1554.
20. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, et al. (2006) Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol 8: 1359-1368.
21. Wadia JS, Dowdy SF, (2005) Transmembrane delivery of protein and peptide drugs by TAT-mediated transduction in the treatment of cancer. Adv Drug Deliv Rev 57: 579-596.
22. He X, Zheng Z, Song T, Wei C, Ma H, et al. (2009) Proliferating cell nuclear antigen destabilizes c-Abl tyrosine kinase and regulates cell apoptosis in response to DNA damage. Apoptosis 14: 268-275.
23. Zhao H, Lo YH, Ma L, Waltz SE, Gray JK, et al. (2011) Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Molecular Cancer Therapeutics 10: 29-36.