Histological and confocal microscopy changes in chronic corneal edema: Implications for endothelial transplantation

Investigative Ophthalmology and Visual Science

Volumn 52, Issue 11, 2011, Pages 8193-8207

  Alomar, Thaer S ^a   Al Aqaba, Mouhamed ^a   Gray, Trevor ^b   Lowe, James ^a   Dua, Harminder S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b NOTTINGHAM UNIVERSITY HOSPITALS NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; CELL DENSITY; CELL STRUCTURE; CELL TRANSPLANTATION; CLINICAL ARTICLE; CONFOCAL MICROSCOPY; CONGENITAL CORNEA DYSTROPHY; CONTROLLED STUDY; CORNEA CELL; CORNEA EDEMA; CORNEA ENDOTHELIUM; DESCEMET STRIPPING ENDOTHELIAL KERATOPLASTY; ELECTRON MICROSCOPY; FEMALE; FIBROBLAST; HISTOLOGY; HISTOPATHOLOGY; HUMAN; KERATOPATHY; MALE; OBSERVATIONAL STUDY; PRIORITY JOURNAL; TRANSMISSION ELECTRON MICROSCOPY; CELL COUNT; CELL SHAPE; CHRONIC DISEASE; CORNEA; INNERVATION; MIDDLE AGED; PATHOLOGY; PENETRATING KERATOPLASTY; PHYSIOLOGY; TRIGEMINAL NERVE DISEASE; ULTRASTRUCTURE; VISUAL ACUITY; VISUAL DISORDER;

ADULT; AGED; AGED, 80 AND OVER; CELL COUNT; CELL SHAPE; CHRONIC DISEASE; CORNEA; CORNEAL EDEMA; DESCEMET STRIPPING ENDOTHELIAL KERATOPLASTY; FEMALE; FIBROBLASTS; FUCHS' ENDOTHELIAL DYSTROPHY; HUMANS; KERATOPLASTY, PENETRATING; MALE; MICROSCOPY, CONFOCAL; MICROSCOPY, ELECTRON; MIDDLE AGED; TRIGEMINAL NERVE DISEASES; VISION DISORDERS; VISUAL ACUITY; YOUNG ADULT;

EID: 84855406595     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8047     Document Type: Article

References (36)

1. Melles GRJ. Posterior lamellar keratoplasty: DLEK to DSEK to DMEK. Cornea. 2006;25(8):879-881.
2. Tan DTH, Mehta JS. Future directions in lamellar corneal transplantation. Cornea. 2007;26:S21-S28.
3. Bahar I, Kaiserman I, McAllum P, Slomovic A, Rootman D. Comparison of posterior lamellar keratoplasty techniques to penetrating keratoplasty. Ophthalmology. 2008;115(9):1525-1533.
4. Studeny P, Farkas A, Vokrojova M, Liskova P, Jirsova K. Descemet membrane endothelial keratoplasty with a stromal rim (DMEK-S). Br J Ophthalmol. 2010;94(7):909-914.
5. Meijering E, Jacob M, Sarria JC, Steiner P, Hirling H, Unser M. Design and validation of a tool for neurite tracing and analysis in fluorescence microscopy images. Cytometry A. 2004;58(2):167-176.
6. Al-Aqaba MA, Alomar T, Miri A, Fares U, Otri AM, Dua HS. Ex vivo confocal microscopy of human corneal nerves. Br J Ophthalmol. 2010;94(9):1251-1257.
7. Kobayashi A, Yokogawa H, Sugiyama K. In vivo laser confocal microscopy of Bowman's layer of the cornea. Ophthalmology. 2006;113(12):2203-2208.
8. Mustonen Rk, McDonald MB, Srivannaboon S, Tan AL, Doubrava MW. In vivo confocal microscopy of Fuchs' endothelial dystrophy. Cornea. 1998;17(5):493-503.
9. Chiou AGY, Kaufman SC, Beuerman RW, Ohta T, Soliman H, Kaufman HE. Confocal microscopy in cornea guttata and Fuchs' endothelial dystrophy. Br J Ophthalmol. 1999;83(2):185-189.
10. Grupcheva CN, Craig JP, Sherwin T, McGhee CNJ. Differential diagnosis of corneal oedema assisted by in vivo confocal microscopy. Clin Exp Ophthalmol. 2001(29):133-137.
11. Iwamoto T, De Voe AG. Electron microscopic studies on Fuchs' combined dystrophy: II. anterior portion of the cornea. Invest Ophthalmol Vis Sci. 1971;10(1):29-40.
12. Eagle RC Jr, Laibson PR, Arentsen JJ. Epithelial abnormalities in chronic corneal edema: a histopathological study. Trans Am Ophthalmol Soc. 1989;87:107-119; discussion 119-124.
13. Muller LJ, Pels L, Vrensen GF. Novel aspects of the ultrastructural organization of human corneal keratocytes. Invest Ophthalmol Vis Sci. 1995;36(13):2557-2567.
14. Jester JV, Barry PA, Lind GJ, PetrollWM, Garana R, Cavanagh HD. Corneal keratocytes: in situ and in vitro organization of cytoskeletal contractile proteins. Invest Ophthalmol Vis Sci. 1994;35(2):730-743.
15. Labbe A, Nicola RD, Dupas B, Auclin F, Baudouin C. Epithelial basement membrane dystrophy: evaluation with the HRT II Rostock Cornea Module. Ophthalmology. 2006;113(8):1301-1308.
16. Laibson PR. Microcystic corneal dystrophy. Trans Am Ophthalmol Soc. 1976;74:488-531.
17. Guthoff R, Baudouin C, Stave J. Atlas of Confocal Laser Scanning In-Vivo Microscopy in Ophthalmology: Principles and Applications in Diagnostic and Therapeutic Ophthalmology. Berlin: Springer: 2006.
18. Said DG, Nubile M, Alomar T, et al. Histologic features of transplanted amniotic membrane: implications for corneal wound healing. Ophthalmology. 2009;116(7):1287-1295.
19. Morishige N, Yamada N, Teranishi S, Chikama T, Nishida T, Takahara A. Detection of subepithelial fibrosis associated with corneal stromal edema by second harmonic generation imaging microscopy. Invest Ophthalmol Vis Sci. 2009;50(7):3145-3150.
20. Patel DV, McGhee CNJ. Mapping of the normal human corneal sub-basal nerve plexus by in vivo laser scanning confocal microscopy. Invest Ophthalmol Vis Sci. 2005;46(12):4485-4488.
21. Oliveira-Soto L, Efron N. Morphology of corneal nerves using confocal microscopy. Cornea 2001;20:374-384.
22. Fuchs E. Dystrophia epithelialis corneae. Graefes Arch Clin Exp Ophthalmol. 1910;76(3):478-508.
23. Jester JV, Petroll WM, Feng W, Essepian J, Cavanagh HD. Radial keratotomy: 1, the wound healing process and measurement of incisional gape in two animal models using in vivo confocal microscopy. Invest Ophthalmol Vis Sci. 1992;33(12):3255-3270.
24. Muller LJ, Pels E, Vrensen GFJM. The specific architecture of the anterior stroma accounts for maintenance of corneal curvature. Br J Ophthalmol. 2001;85(4):437-443.
25. Yuen HKL, Rassier CE, Jardeleza MSR, et al. A morphologic study of Fuchs dystrophy and bullous keratopathy. Cornea. 2005;24(3):319-327.
26. Akhtar S, Bron AJ, Hawksworth NR, Bonshek RE, Meek KM. Ultrastructural morphology and expression of proteoglycans, betaig-h3, tenascin-C, fibrillin-1, and fibronectin in bullous keratopathy. Br J Ophthalmol. 2001;85(6):720-731.
27. Vesaluoma M, Perez-Santonja J, Petroll WM, Linna T, Alio J, Tervo T. Corneal stromal changes induced by myopic LASIK. Invest Ophthalmol Vis Sci. 2000;41(2):369-376.
28. Sonigo B, Iordanidou V, Chong-Sit D, et al. In vivo corneal confocal microscopy comparison of intralase femtosecond laser and mechanical microkeratome for laser in situ keratomileusis. Invest Ophthalmol Vis Sci. 2006;47(7):2803-2811.
29. Fini ME. Keratocyte and fibroblast phenotypes in the repairing cornea. Prog Retin Eye Res. 1999;18(4):529-551.
30. Kitano S, Goldman JN. Cytologic and histochemical changes in corneal wound repair. Arch Ophthalmol. 1966;76(3):345-354.
31. Matsuda H, Smelser GK. Electron microscopy of corneal wound healing. Exp Eye Res. 1973;16(6):427-442.
32. Jester JV, Petroll WM, Barry PA, Cavanagh HD. Expression of alpha-smooth muscle (alpha-SM) actin during corneal stromal wound healing. Invest Ophthalmol Vis Sci. 1995;36(5):809-819.
33. Park CK, Kim JH. Comparison of wound healing after photorefractive keratectomy and laser in situ keratomileusis in rabbits. J Cataract Refract Surg. 1999;25(6):842-850.
34. Mohan RR, Hutcheon AEK, Choi R, et al. Apoptosis, necrosis, proliferation, and myofibroblast generation in the stroma following LASIK and PRK. Exp Eye Res. 2003;76(1):71-87.
35. Ambrosio R, Wilson SE. LASIK vs LASEK vs PRK: Advantages and indications. Semin Ophthalmol. 2003;18(1):2-10.
36. Vincent AL, Patel DV, McGhee CNJ. Inherited corneal disease: the evolving molecular, genetic and imaging revolution. Clin Exp Ophthalmol. 2005(33):303-316.