Tolerance after Solid Organ and Hematopoietic Cell Transplantation

Biology of Blood and Marrow Transplantation

Volumn 18, Issue 1 SUPPL., 2012, Pages

  Szabolcs, Paul ^a   Burlingham, William J ^b   Thomson, Angus W ^c  

^a CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^b UNIVERSITY OF WISCONSIN MADISON   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALEMTUZUMAB; AZATHIOPRINE; BASILIXIMAB; CALCINEURIN INHIBITOR; CYCLOSPORIN; CYCLOSPORIN A; HLA ANTIGEN; HYDROXYUREA; IMMUNOSUPPRESSIVE AGENT; INFLIXIMAB; PREDNISONE; RITUXIMAB; STEROID; TACROLIMUS; THIOTEPA; THYMOCYTE ANTIBODY;

ALLOGENIC BONE MARROW TRANSPLANTATION; ALLOIMMUNITY; ARTICLE; BLOOD TRANSFUSION; CELLULAR IMMUNITY; CORTICOSTEROID THERAPY; DRUG BLOOD LEVEL; DRUG WITHDRAWAL; GRAFT VERSUS HOST REACTION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HLA TYPING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; LIVER GRAFT REJECTION; LIVER TRANSPLANTATION; LOW DRUG DOSE; LUNG GRAFT REJECTION; LUNG TRANSPLANTATION; MONOTHERAPY; MYELOABLATIVE CONDITIONING; NONHUMAN; ORGAN TRANSPLANTATION; REGULATORY T LYMPHOCYTE; SINGLE DRUG DOSE; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TRANSPLANTATION TOLERANCE; WHOLE BODY RADIATION;

HEMATOPOIETIC STEM CELL TRANSPLANTATION; HUMANS; IMMUNE TOLERANCE; ORGAN TRANSPLANTATION; TRANSPLANTATION, HOMOLOGOUS;

EID: 84855375965     PISSN: 10838791     EISSN: 15236536     Source Type: Journal    
DOI: 10.1016/j.bbmt.2011.11.005     Document Type: Article

References (33)

1. Sykes M. Mechanisms of transplantation tolerance in animals and humans. Transplantation 2009, 87(9 suppl):S67-S69.
2. Kawai T., Cosimi A.B., Sachs D.H. Preclinical and clinical studies on the induction of renal allograft tolerance through transient mixed chimerism. Curr Opin Organ Transplant 2011, 16:366-371.
3. Eapen M., Rubinstein P., Zhang M.J., et al. Comparable long-term survival after unrelated and HLA-matched sibling donor hematopoietic stem cell transplantations for acute leukemia in children younger than 18 months. J Clin Oncol 2006, 24:145-151.
4. Brunstein C.G., Gutman J.A., Weisdorf D.J., et al. Allogeneic hematopoietic cell transplantation for hematologic malignancy: relative risks and benefits of double umbilical cord blood. Blood 2010, 116:4693-4699.
5. Ponce D.M., Zheng J., Gonzales A.M., et al. Reduced late mortality risk contributes to similar survival after double-unit cord blood transplantation compared with related and unrelated donor hematopoietic stem cell transplantation. Biol Blood Marrow Transplant 2011, 17:1316-1326.
6. Roncarolo M.G., Gregori S., Lucarelli B., Ciceri F., Bacchetta R. Clinical tolerance in allogeneic hematopoietic stem cell transplantation. Immunol Rev 2011, 241:145-163.
7. Andreani M., Nesci S., Lucarelli G., et al. Long-term survival of ex-thalassemic patients with persistent mixed chimerism after bone marrow transplantation. Bone Marrow Transplant 2000, 25:401-404.
8. Walters M.C., Patience M., Leisenring W., et al. Stable mixed hematopoietic chimerism after bone marrow transplantation for sickle cell anemia. Biol Blood Marrow Transplant 2001, 7:665-673.
9. Edinger M., Hoffmann P. Regulatory T cells in stem cell transplantation: strategies and first clinical experiences. Curr Opin Immunol 2011, 23:679-684.
10. Newell K.A., Asare A., Kirk A.D., et al. Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010, 120:1836-1847.
11. Sagoo P., Perucha E., Sawitzki B., et al. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010, 120:1848-1861.
12. Starzl T.E., Demetris A.J., Trucco M., et al. Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology 1993, 17:1127-1152.
13. Kawai T., Cosimi A.B., Spitzer T.R., et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N Engl J Med 2008, 358:353-361.
14. Scandling J.D., Busque S., Dejbakhsh-Jones S., et al. Tolerance and chimerism after renal and hematopoietic-cell transplantation. N Engl J Med 2008, 358:362-368.
15. Thomson A.W., Knolle P.A. Antigen-presenting cell function in the tolerogenic liver environment. Nat Rev 2010, 10:753-766.
16. Qian S., Demetris A.J., Murase N., et al. Murine liver allograft transplantation: tolerance and donor cell chimerism. Hepatology 1994, 19:916-924.
17. Mazariegos G.V. Immunosuppression withdrawal after liver transplantation: what are the next steps?. Transplantation 2011, 91:697-699.
18. Sanchez-Fueyo A., Strom T.B. Immunologic basis of graft rejection and tolerance following transplantation of liver or other solid organs. Gastroenterology 2011, 140:51-64.
19. Martinez-Llordella M., Lozano J.J., Puig-Pey I., et al. Using transcriptional profiling to develop a diagnostic test of operational tolerance in liver transplant recipients. J Clin Invest 2008, 118:2845-2857.
20. Murase N., Starzl T.E., Ye Q., et al. Multilineage hematopoietic reconstitution of supralethally irradiated rats by syngeneic whole organ transplantation. With particular reference to the liver. Transplantation 1996, 61:1-4.
21. Chan E.Y., Larson A.M., Gernsheimer T.B., et al. Recipient and donor factors influence the incidence of graft-vs.-host disease in liver transplant patients. Liver Transpl 2007, 13:516-522.
22. Alexander S.I., Smith N., Hu M., et al. Chimerism and tolerance in a recipient of a deceased-donor liver transplant. N Engl J Med 2008, 358:369-374.
23. Wood K.J. Passenger leukocytes and microchimerism: what role in tolerance induction?. Transplantation 2003, 75(9 suppl):17S-20S.
24. Fontes P., Rao A.S., Demetris A.J., et al. Bone marrow augmentation of donor-cell chimerism in kidney, liver, heart, and pancreas islet transplantation. Lancet 1994, 344:151-155.
25. Abu-Farsakh H.A., Katz R.L., Atkinson N., Champlin R.E. Prognostic factors in bronchoalveolar lavage in 77 patients with bone marrow transplants. Acta Cytol 1995, 39:1081-1088.
26. Rastellini C., Lu L., Ricordi C., et al. Granulocyte/macrophage colony-stimulating factor-stimulated hepatic dendritic cell progenitors prolong pancreatic isletallograft survival. Transplantation 1995, 60:1366-1370.
27. Morelli A.E., Thomson A.W. Tolerogenic dendritic cells and the quest for transplant tolerance. Nat Rev 2007, 7:610-621.
28. Sato K., Yamashita N., Yamashita N., Baba M., Matsuyama T. Regulatory dendritic cells protect mice from murine acute graft-versus-host disease and leukemia relapse. Immunity 2003, 18:367-379.
29. Naranjo-Gomez M., Raich-Regue D., Onate C., et al. Comparative study of clinical grade human tolerogenic dendritic cells. J Transl Med 2011, 9:89.
30. Thomson A.W., Turnquist H.R., Zahorchak A.F., Raimondi G. Tolerogenic dendritic cell-regulatory T-cell interaction and the promotion of transplant tolerance. Transplantation 2009, 87(9 suppl):S86-S90.
31. Anderson J.E., Anasetti C., Appelbaum F.R., et al. Unrelated donor marrow transplantation for myelodysplasia (MDS) and MDS-related acute myeloid leukaemia. Br J Haematol 1996, 93:59-67.
32. Tokita D., Mazariegos G.V., Zahorchak A.F., et al. High PD-L1/CD86 ratio on plasmacytoid dendritic cells correlates with elevated T-regulatory cells in liver transplant tolerance. Transplantation 2008, 85:369-377.
33. Brunstein C.G., Miller J.S., Cao Q., et al. Infusion of exvivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics. Blood 2011, 117:1061-1070.