Safety and efficacy evaluation of tretinoin cream 0.02% for the reduction of photodamage: A pilot study

Journal of Drugs in Dermatology

Volumn 11, Issue 1, 2012, Pages 83-90

  Kircik, Leon H ^a,b  

^a MOUNT SINAI MEDICAL CENTER   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

RETINOIC ACID;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; DISEASE SEVERITY; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; DRY SKIN; FACIAL PHOTODAMAGE; FEMALE; GASTRITIS; HUMAN; HUMAN TISSUE; HYPERPIGMENTATION; ISCHIALGIA; MEDICAL PHOTOGRAPHY; OPEN STUDY; PHOTODAMAGE; PILOT STUDY; SKIN ABRASION; SKIN BIOPSY; SKIN BURNING SENSATION; SKIN DISEASE; SKIN PRURITUS; SKIN REDNESS; TELANGIECTASIA; TREATMENT DURATION; WRINKLE;

ADMINISTRATION, TOPICAL; AGED; DRUG EVALUATION; EMOLLIENTS; FACE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MALE; MIDDLE AGED; PILOT PROJECTS; SKIN AGING; TREATMENT OUTCOME; TRETINOIN;

EID: 84855370155     PISSN: 15459616     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (43)

1. Sjerobabski Masnec I, Poduje S. Photoaging. Coll Antropol. 2008;32(suppl 2):177-180.
2. Farage MA, Miller KW, Elsner P, Maibach HI. Functional and physiological characteristics of the aging skin. Aging Clin Exp Res.2008;20(3):195-200.
3. Samuel M, Brooke RC, Hollis S, Griffiths CE. Interventions for photodamaged skin. Cochrane Database Syst Rev. 2005(1):CD001782.
4. Affinito P, Palomba S, Sorrentino C, et al. Effects of postmenopausal hypoestrogenism on skin collagen. Maturitas.1999;33(3):239-247.
5. Guercio-Hauer C, Macfarlane DF, Deleo VA. Photodamage, photoaging and photoprotection of the skin. Am Fam Physician. 1994;50(2):327-332. (Pubitemid 24242312)
6. Fritschi L, Green A, Solomon PJ. Sun exposure in Australian adolescents. J Am Acad Dermatol.1992;27(1):25-28.
7. Grady D, Ernster V. Does cigarette smoking make you ugly and old? Am J Epidemiol. 1992;135(8):839-842.
8. Maddin S, Lauharanta J, Agache P, Burrows L, Zultak M, Bulger L. Isotretinoin improves the appearance of photodamaged skin: results of a 36-week, multicenter, double-blind, placebo-controlled trial. J Am Acad Dermatol.2000;42(1 pt 1):56-63. (Pubitemid 30470320)
9. Griffiths CE, Goldfarb MT, Finkel LJ, et al. Topical tretinoin (retinoic acid) treatment of hyperpigmented lesions associated with photoaging in Chinese and Japanese patients: a vehicle-controlled trial. J Am Acad Dermatol. 1994;30(1):76-84. (Pubitemid 24033823)
10. Gupta MA, Gupta AK. Psychodermatology: an update. J Am Acad Dermatol.1996;34(6):1030-1046. (Pubitemid 26170771)
11. Rokhsar CK, Lee S, Fitzpatrick RE. Review of photorejuvenation: devices, cosmeceuticals, or both? Dermatol Surg. 2005;31(9 pt 2):1166-1178.
12. Shamban AT. Current and new treatments of photodamaged skin. Facial Plast Surg. 2009;25(5):337-346.
13. Renova 0.05% [package insert]. Raritan, NJ: Ortho Dermatologics, a division of Ortho-McNeil Pharmaceutical Corporation; July 2000.
14. Bhawan J, Gonzalez-Serva A, Nehal K, et al. Effects of tretinoin on photodamaged skin. A histologic study. Arch Dermatol. 1991;127(5):666-672.
15. Bhawan J, Andersen W, Lee J, Labadie R, Solares G. Photoaging versus intrinsic aging: a morphologic assessment of facial skin. J Cutan Pathol. 1995;22(2):154-159.
16. Bhawan J, Olsen E, Lufrano L, Thorne EG, Schwab B, Gilchrest BA. Histologic evaluation of the long term effects of tretinoin on photodamaged skin. J Dermatol Sci.1996;11(3):177-182. (Pubitemid 26078167)
17. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med.1997;337(20):1419-1428. (Pubitemid 27497889)
18. Griffiths CE, Finkel LJ, Tranfaglia MG, Hamilton TA, Voorhees JJ. An in vivo experimental model for effects of topical retinoic acid in human skin. Br J Dermatol.1993;129(4):389-394. (Pubitemid 23308240)
19. Griffiths CE, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid). N Engl J Med. 1993;329(8):530-535. (Pubitemid 23232621)
20. Grove GL, Grove MJ, Leyden JJ, et al. Skin replica analysis of photodamaged skin after therapy with tretinoin emollient cream. J Am Acad Dermatol. 1991;25(2 pt 1):231-237.
21. Kossard S, Anderson P, Davies A, Cooper A. Histological evaluation of the effect of 0.05% tretinoin in the treatment of photo damaged skin. Geographic differences in elastosis in baseline biopsies. Australas J Dermatol. 1993;34(3):89-95.
22. Lever L, Kumar P, Marks R. Topical retinoic acid for treatment of solar damage. Br J Dermatol.1990;122(1):91-98. (Pubitemid 20047040)
23. Leyden JJ, Grove GL, Grove MJ, Thorne EG, Lufrano L. Treatment of photodamaged facial skin with topical tretinoin. J Am Acad Dermatol. 1989;21(3 pt 2):638-644. (Pubitemid 19211188)
24. Lundin A, Berne B, Michaelsson G. Topical retinoic acid treatment of photoaged skin: its effects on hyaluronan distribution in epidermis and on hyaluronan and retinoic acid in suction blister fluid. Acta Derm Venereol.1992;72(6):423-427. (Pubitemid 23028343)
25. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ. Topical tretinoin improves photoaged skin. A double-blind vehicle-controlled study. JAMA. 1988;259(4):527-532.
26. Andreano JM, Bergfeld WF, Medendorp SV. Tretinoin emollient cream 0.01% for the treatment of photoaged skin. Cleve Clin J Med. 1993;60(1):49-55. (Pubitemid 23036199)
27. Barel AO, Delune M, Clarys P, Gabard B. Treatment of photodamaged facial skin with topical tretinoin: a blinded, vehicle controlled half-side study. Nouv Dermatol. 1995;14:585-591.
28. Griffiths CE, Kang S, Ellis CN, et al. Two concentrations of topical tretinoin (retinoic acid) cause similar improvement of photoaging but different degrees of irritation. A double-blind, vehicle-controlled comparison of 0.1% and 0.025% tretinoin creams. Arch Dermatol. 1995;131(9):1037-1044.
29. Kang S, Bergfeld W, Gottlieb AB, et al. Long-term efficacy and safety of tretinoin emollient cream 0.05% in the treatment of photodamaged facial skin: a two-year, randomized, placebo-controlled trial. Am J Clin Dermatol. 2005;6(4):245-253. (Pubitemid 41159411)
30. Kang S, Leyden JJ, Lowe NJ, et al. Tazarotene cream for the treatment of facial photodamage: a multicenter, investigator-masked, randomized, vehicle-controlled, parallel comparison of 0.01%, 0.025%, 0.05%, and 0.1% tazarotene creams with 0.05% tretinoin emollient cream applied once daily for 24 weeks. Arch Dermatol. 2001;137(12):1597-1604. (Pubitemid 34000908)
31. Kimbrough-Green CK, Griffiths CE, Finkel LJ, et al. Topical retinoic acid (tretinoin) for melasma in black patients. A vehicle-controlled clinical trial. Arch Dermatol. 1994;130(6):727-733. (Pubitemid 24182681)
32. Kligman LH, Mezick JA, Capetola RJ, Thorne EG. Lifetime topical application of tretinoin to hairless mice. Acta Derm Venereol. 1992;72(6):418-422. (Pubitemid 23028342)
33. Lowe PM, Woods J, Lewis A, Davies A, Cooper AJ. Topical tretinoin improves the appearance of photo damaged skin. Australas J Dermatol. 1994;35(1):1-9.
34. Nyirady J, Bergfeld W, Ellis C, et al. Tretinoin cream 0.02% for the treatment of photodamaged facial skin: a review of 2 double-blind clinical studies. Cutis. 2001;68(2):135-142. (Pubitemid 33757346)
35. Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream for photodamaged skin: results of 48-week, multicenter, double-blind studies. J Am Acad Dermatol. 1997;37(2 pt 1):217-226. (Pubitemid 27355707)
36. Olsen EA, Katz HI, Levine N, et al. Sustained improvement in photodamaged skin with reduced tretinoin emollient cream treatment regimen: effect of once-weekly and three-times-weekly applications. J Am Acad Dermatol. 1997;37(2 pt 1):227-230. (Pubitemid 27355708)
37. Olsen EA, Katz HI, Levine N, et al. Tretinoin emollient cream: a new therapy for photodamaged skin. J Am Acad Dermatol. 1992;26(2 pt 1):215-224.
38. Rafal ES, Griffiths CE, Ditre CM, et al. Topical tretinoin (retinoic acid) treatment for liver spots associated with photodamage. N Engl J Med. 1992;326(6):368-374.
39. Thorne EG. Long-term clinical experience with a topical retinoid. Br J Dermatol. 1992;127 (suppl 41):31-36.
40. Weinstein GD, Nigra TP, Pochi PE, et al. Topical tretinoin for treatment of photodamaged skin. A multicenter study. Arch Dermatol. 1991;127(5):659-665.
41. Yamamoto O, Bhawan J, Solares G, Tsay AW, Gilchrest BA. Ultrastructural effects of topical tretinoin on dermo-epidermal junction and papillary dermis in photodamaged skin. A controlled study. Exp Dermatol. 1995;4(3):146-154.
42. Kligman AM, Grove GL, Hirose R, Leyden JJ. Topical tretinoin for photoaged skin. J Am Acad Dermatol. 1986;15(4 pt 2):836-859. (Pubitemid 17170790)
43. Fu JJ, Hillebrand GG, Raleigh P, et al. A randomized, controlled comparative study of the wrinkle reduction benefits of a cosmetic niacinamide/peptide/retinyl propionate product regimen vs. a prescription 0.02% tretinoin product regimen. Br J Dermatol. 2010;162(3):647-654.