New miniature stirred-tank bioreactors for parallel study of enzymatic biomass hydrolysis

Bioresource Technology

Volumn 106, Issue , 2012, Pages 138-146

  Riedlberger, Peter ^a   Weuster Botz, Dirk ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Biomass; Enzymatic hydrolysis; High throughput bioreaction system; Mixing characteristics; Stirred tank bioreactor

Indexed keywords

BIOPROCESS DEVELOPMENT; CELLULASE COMPLEX; ENZYME LOADING; FERMENTABLE SUGARS; HIGH-THROUGHPUT; MICROCRYSTALLINE CELLULOSE; MIXING CHARACTERISTICS; PARALLEL STIRRED-TANK BIOREACTORS; PARALLELIZATIONS; PLANT MATERIAL; PRE-TREATMENT; PRE-TREATMENTS; REACTION CONDITIONS; S-SHAPED; SCALE-UP; SOLIDS LOADING; WHEAT STRAWS;

BIOCONVERSION; BIOMASS; BIOREACTORS; CELLULOSE; CRYSTALLINE MATERIALS; SUGARS; TANKS (CONTAINERS);

ENZYMATIC HYDROLYSIS;

HEMICELLULOSE; MICROCRYSTALLINE CELLULOSE;

BIOMASS; BIOREACTOR; CELLULOSE; ENZYME ACTIVITY; HOMOGENEITY; HYDROLYSIS; SUGAR;

ARTICLE; BIOMASS; BIOPROCESS; HYDROLYSIS; IMPELLER; NONHUMAN; PARALLEL DESIGN; PRIORITY JOURNAL; REACTOR OPTIMIZATION; STIRRED REACTOR; SUSPENSION;

BETA-GLUCOSIDASE; BIOMASS; BIOREACTORS; BIOTECHNOLOGY; CELLULASE; CRYSTALLIZATION; ENZYMES; GLUCOSE; HYDROLYSIS; MINIATURIZATION; SUSPENSIONS; TIME FACTORS; TRITICUM; WASTE PRODUCTS; XYLOSE;

TRITICUM AESTIVUM;

EID: 84855353678     PISSN: 09608524     EISSN: 18732976     Source Type: Journal    
DOI: 10.1016/j.biortech.2011.12.019     Document Type: Article

References (35)

1. Bansal P., Hall M., Realff M.J., Lee J.H., Bommarius A.S. Modeling cellulase kinetics on lignocellulosic substrates. Biotechnol. Adv. 2009, 27:833-848.
2. Bommarius A.S., Katona A., Cheben S.E., Patel A.S., Ragauskas A.J., Knudson K., Pu Y. Cellulase kinetics as a function of cellulose pretreatment. Metab. Eng. 2008, 10:370-381.
3. Chundawat S.P.S., Balan V., Dale B.E. High-throughput microplate technique for enzymatic hydrolysis of lignocellulosic biomass. Biotechnol. Bioeng. 2008, 99:1281-1294.
4. Ehrhardt M.R., Monz T.O., Root T.W., Connelly R.K., Scott C.T., Klingenberg D.J. Rheology of dilute acid hydrolyzed corn stover at high solids concentration. Appl. Biochem. Biotechnol. 2010, 160:1102-1115.
5. Ganesh K., Joshi J.B., Sawant S.B. Cellulase deactivation in a stirred reactor. Biochem. Eng. J. 2000, 4:137-141.
6. Ghose T.K. Measurement of cellulose activities. Pure Appl. Chem. 1987, 59(2):257-268.
7. Hortsch R., Weuster-Botz D. Power consumption and mixing energy dissipation in a milliliter-scale bioreactor. Biotechnol. Prog. 2010, 26(2):595-599.
8. Hoefel T., Wittmann E., Reinecke L., Weuster-Botz D. Reaction engineering studies for the production of 2-hydroxyisobutyric acid with recombinant Cupriavidus necator H 16. Appl. Microbiol. Biotechnol. 2010, 88:477-484.
9. Kim Y., Ximenes E., Mosier N.S., Ladisch M.R. Soluble inhibitors/deactivators of cellulase enzymes from lignocellulosic biomass. Enzyme Microb. Technol. 2011, 48:408-415.
10. King B.C., Donnelly M.K., Bergstrom G.C., Walker L.P., Gibson D.M. An optimized microplate assay system for quantitative evaluation of plant cell wall-degrading enzyme activity of fungal culture extracts. Biotechnol. Bioeng. 2009, 102(4):1033-1044.
11. Knutsen J.S., Liberatore M.W. Rheology of high-solids biomass slurries for biorefinery applications. J. Rheol. 2009, 53:877-892.
12. Knutsen J.S., Liberatore M.W. Rheology modification and enzyme kinetics of high solids cellulosic slurries. Energy Fuels 2010, 24:3267-3274.
13. Kumar R., Wyman C.E. Effect of enzyme supplementation at moderate cellulase loadings on initial glucose and xylose release from corn stover solids pretreated by leading technologies. Biotechnol. Bioeng. 2009, 102(2):457-467.
14. Lynd L.R., Laser M.S., Bransby D., Dale B.E., Davison B., Hamilton R., Himmel M., Keller M., McMillan J.D., Sheehan J., Wyman C.E. How biotech can transform biofuels. Nat. Biotechnol. 2008, 26(2):169-172.
15. Metzner A.B., Otto R.E. Agitation of non-Newtonian fluids. AIChE J. 1957, 3:3-10.
16. Peter C.P., Lotter S., Maier U., Büchs J. Impact of out-of-phase conditions on screening results in shaking flask experiments. Biochem. Eng. J. 2004, 17:205-215.
17. Pimenova N.V., Hanley T.R. Measurement of rheological properties of corn stover suspensions. Appl. Biochem. Biotechnol. 2003, 105:383-392.
18. Pimenova N.V., Hanley T.R. Effect of corn stover concentration on rheological characteristics. Appl. Biochem. Biotechnol. 2004, 113:347-360.
19. Puskeiler R., Kaufmann K., Weuster-Botz D. Development, parallelization, and automation of a gas-inducing milliliter-scale bioreactor for high-throughput bioprocess design (HTBD). Biotechnol. Bioeng. 2005, 89:512-523.
20. Riedlberger, P., Weuster-Botz, D., 2010. Rührorgan für Flüssigkeiten. German Patent Application DE 20 2010 011 902 U1.
21. Roche C.M., Dibble C.J., Knutsen J.S., Stickel J.J., Liberatore M.W. Particle concentration and yield stress of biomass slurries during enzymatic hydrolysis at high-solids loadings. Biotechnol. Bioeng. 2009, 104(2):290-300.
22. Roche C.M., Dibble C.J., Stickel J.J. Laboratory-scale method for enzymatic saccharification of lignocellulosic biomass at high-solids loadings. Biotechnol. Biofuels 2009, 2:28.
23. Samaniuk J.R., Scott C.T., Root T.W., Klingenberg D.J. The effect of high intensity mixing on the enzymatic hydrolysis of concentrated cellulose fiber suspensions. Bioresour. Technol. 2011, 102:4489-4494.
24. Santoro N., Cantu S.L., Tornqvist C.E., Falbel T.G., Bolivar J.L., Patterson S.E., Pauly M., Walton J.D. A high-throughput platform for screening milligram quantities of plant biomass for lignocellulosic digestibility. Bioenerg. Res. 2010, 3:93-102.
25. Sathitsuksanoh N., Zhu Z., Sungsool W., Zhang Y.H.P. Cellulose solvent-based biomass pretreatment breaks highly ordered hydrogen bonds in cellulose fibers of switchgrass. Biotechnol. Bioeng. 2011, 108(3):521-529.
26. Sluiter, A., Hames, B., Ruiz, R., Scarlata, C., Sluiter, J., Templeton, D., Crocker, D., 2008. Determination of structural carbohydrates and lignin in Biomass, NREL Laboratory Analytical Procedure, National Renewable Energy Laboratory, Golden, CO, USA.
27. Song L., Laguerre S., Dumon C., Botonnet S., ÓDonohue M.J. A high-throughput screening system for the evaluation of biomass-hydrolyzing glycoside hydrolases. Bioresour. Technol. 2010, 101:8237-8243.
28. Stickel J.S., Knutsen J.S., Liberatore M.W., Luu W., Bousfield D.W., Klingenberg D.J., Scott C.T., Root T.W., Ehrhardt M.R., Monz T.O. Rheology measurements of a biomass slurry: an inter-laboratory study. Rheol. Acta 2009, 48:1005-1015.
29. Stickel J.J., Powell R.L. Fluid mechanics and rheology of dense suspensions. Annu. Rev. Fluid Mech. 2005, 37(1):129-149.
30. Studer M.H., DeMartini J.D., Brethauer S., McKenzie H.L., Wyman C.E. Engineering of a high-throughput screening system to identify cellulosic biomass, pretreatments, and enzyme formulations that enhance sugar release. Biotechnol. Bioeng. 2010, 105(2):231-238.
31. Viamajala S., McMillan J.D., Schell D.J., Elander R.T. Rheology of cron stover slurries at high solids concentration and paricle size. Bioresour. Technol. 2009, 100:925-934.
32. Weuster-Botz D., Puskeiler R., Kusterer A., Kaufmann K., John G.T., Arnold M. Methods and milliliter scale devices for high-throughput bioprocess design. Bioprocess Biosyst. Eng. 2005, 28:109-119.
33. Wyman C.E., Dale B.E., Elander R.T., Holtzapple M., Ladisch M.R., Lee Y.Y. Coordinated development of leading biomass pretreatment technologies. Bioresour. Technol. 2005, 96:1959-1966.
34. Wyman C.E. Biomass ethanol: technical progress, opportunities, and commercial challenges. Annu. Rev. Energy Environ. 1999, 24(1):189.
35. Zlokarnik M. Stirring 2005, Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.