Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones

Journal of Cerebral Blood Flow and Metabolism

Volumn 32, Issue 1, 2012, Pages 17-22

  Cimarosti, Helena ^a,b   Ashikaga, Emi ^a   Jaafari, Nadia ^a   Dearden, Laura ^a   Rubin, Philip ^a   Wilkinson, Kevin A ^a   Henley, Jeremy M ^a  

^a UNIVERSITY OF BRISTOL   (United Kingdom)

^b UNIVERSITY OF READING   (United Kingdom)

Author keywords

ischemia; neuronal culture; oxygen and glucose deprivation (OGD); posttranslational modification; SENP 1; SUMO

Indexed keywords

GLUCOSE; OXYGEN; PROTEINASE; SENP 1 PROTEIN; SUMO 1 PROTEIN; SUMO 2 PROTEIN; SUMO 3 PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DEATH; CONTROLLED STUDY; IN VITRO STUDY; NERVE CELL; NEUROPROTECTION; NONHUMAN; OXYGEN AND GLUCOSE DEPRIVATION; PRIORITY JOURNAL; PROCEDURES CONCERNING CELLS; PROTEIN MODIFICATION; RAT; SUMOYLATION;

ANIMALS; CATALYTIC DOMAIN; CELL DEATH; CELLS, CULTURED; CLONING, MOLECULAR; ENDOPEPTIDASES; GLUCOSE; GREEN FLUORESCENT PROTEINS; HIPPOCAMPUS; MUTATION; NEURONS; OXYGEN; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SINDBIS VIRUS; SUMO-1 PROTEIN; SUMOYLATION;

EID: 84855339798     PISSN: 0271678X     EISSN: 15597016     Source Type: Journal    
DOI: 10.1038/jcbfm.2011.146     Document Type: Article

References (16)

1. Cimarosti H, Lindberg C, Bomholt SF, Ronn LC, Henley JM (2008) Increased protein SUMOylation following focal cerebral ischemia. Neuropharmacology 54:280-9
2. Datwyler AL, Lättig-Tünnemann G, Yang W, Paschen W, Lee SL, Dirnagl U, Endres M, Harms C (2011) SUMO2/3 conjugation is an endogenous neuroprotective mechanism. J Cereb Blood Flow Metab In press. doi: 10.1038/jcbfm.2011.112
3. Golebiowski F, Matic I, Tatham MH, Cole C, Yin Y, Nakamura A, Cox J, Barton GJ, Mann M, Hay RT (2009) System-wide changes to SUMO modifications in response to heat shock. Sci Signal 2:ra24
4. Ja Lee Y, Castri P, Bembry J, Maric D, Auh S, Hallenbeck JM (2009) SUMOylation participates in induction of ischemic tolerance. J Neurochem 109:257-67
5. Kantamneni S, Wilkinson KA, Jaafari N, Ashikaga E, Rocca D, Rubin P, Jacobs S, Nishimune A, Henley JM (2011) Activity dependent SUMOylation of the brain specific scaffolding protein GISP. Biochem Biophys Res Com-mun 409:657-62
6. Lee YJ, Miyake S, Wakita H, McMullen DC, Azuma Y, Auh S, Hallenbeck JM (2007) Protein SUMOylation is massively increased in hibernation torpor and is critical for the cytoprotection provided by ischemic preconditioning and hypothermia in SHSY5Y cells. J Cereb Blood Flow Metab 27:950-62 (Pubitemid 46659023)
7. Loftus LT, Gala R, Yang T, Jessick VJ, Ashley MD, Ordonez AN, Thompson SJ, Simon RP, Meller R (2009) Sumo-2/3-ylation following in vitro modeled ischemia is reduced in delayed ischemic tolerance. Brain Res 1272:71-80
8. Martin S, Nishimune A, Mellor JR, Henley JM (2007) SUMOylation regulates kainate-receptor-mediated synaptic transmission. Nature 447:321-5 (Pubitemid 46788827)
9. Shao R, Zhang FP, Tian F, Anders Friberg P, Wang X, Sjoland H, Billig H (2004) Increase of SUMO-1 expression in response to hypoxia: direct interaction with HIF-1alpha in adult mouse brain and heart in vivo. FEBS Lett 569:293-300 (Pubitemid 38844635)
10. Tatham MH, Matic I, Mann M, Hay RT (2011) Comparative Proteomic analysis identifies a role for SUMO in protein quality control. Sci Signal 4:rs4
11. Wahl AS, Buchthal B, Rode F, Bomholt SF, Freitag HE, Hardingham GE, Ronn LC, Bading H (2009) Hypoxic/ischemic conditions induce expression of the putative pro-death gene Clca1 via activation of extrasynaptic N-methyl-D-aspartate receptors. Neuroscience 158:344-52
12. Wilkinson KA, Henley JM (2010) Mechanisms, regulation and consequences of protein SUMOylation. Biochem J 428:133-45
13. Wilkinson KA, Nakamura Y, Henley JM (2010) Targets and consequences of protein SUMOylation in neurons. Brain Res Rev 64:195-212
14. Xu X, Vatsyayan J, Gao C, Bakkenist CJ, Hu J (2010) Sumoylation of eIF4E activates mRNA translation. EMBO Rep 11:299-304
15. Yang W, Sheng H, Warner DS, Paschen W (2008a) Transient global cerebral ischemia induces a massive increase in protein sumoylation. J Cereb Blood Flow Metab 28:269-79 (Pubitemid 351161280)
16. Yang W, Sheng H, Warner DS, Paschen W (2008b) Transient focal cerebral ischemia induces a dramatic activation of small ubiquitin-like modifier conjugation. J Cereb Blood Flow Metab 28:892-6 (Pubitemid 351589638)