A lanthanide complex with dual biosensing properties: CEST (chemical exchange saturation transfer) and BIRDS (biosensor imaging of redundant deviation in shifts) with europium DOTA-tetraglycinate

NMR in Biomedicine

Volumn 24, Issue 10, 2011, Pages 1216-1225

  Coman, Daniel ^a,b   Kiefer, Garry E ^c   Rothman, Douglas L ^a,b,d   Sherry, A Dean ^e,f   Hyder, Fahmeed ^a,b,d  

^a YALE UNIVERSITY   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Macrocyclics   (United States)

^d Yale University   (United States)

^e UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^f UNIVERSITY OF TEXAS AT DALLAS   (United States)

Author keywords

Amide protons; DIACEST; Hydroxyl protons; Methyl protons; PARACEST; PH; Temperature

Indexed keywords

AMIDE PROTON; BIOSENSING; BOUND WATERS; BULK WATER; CHEMICAL EXCHANGE SATURATION TRANSFER; CONTRAST AGENT; DIACEST; HIGH SPATIAL RESOLUTION; IN-VITRO; LANTHANIDE COMPLEX; MACROCYCLES; MOLECULAR IMAGING; PARACEST; PROTON EXCHANGE; PROTON RESONANCES; REDUNDANT INFORMATIONS; TEMPERATURE SENSITIVITY;

AMIDES; BIOSENSORS; EUROPIUM; IONS; PARAMAGNETIC MATERIALS; PARAMAGNETISM; PH; PROTONS; SPHERES; TEMPERATURE;

ION EXCHANGE;

CONTRAST MEDIUM; EUROPIUM; LANTHANIDE; MACROCYCLIC COMPOUND; METAL COMPLEX; TETRAGLYCINATE; TETRAXETAN; UNCLASSIFIED DRUG; WATER;

ARTICLE; BIOSENSOR; BIOSENSOR IMAGING OF REDUNDANT DEVIATION IN SHIFT; CHEMICAL EXCHANGE SATURATION TRANSFER; IN VITRO STUDY; MOLECULAR IMAGING; NUCLEAR MAGNETIC RESONANCE; PH; PRIORITY JOURNAL; PROTON TRANSPORT; QUALITATIVE ANALYSIS; TEMPERATURE; TEMPERATURE SENSITIVITY;

BIOSENSING TECHNIQUES; COORDINATION COMPLEXES; EUROPIUM; MAGNETIC RESONANCE IMAGING; PHANTOMS, IMAGING; TEMPERATURE; TIME FACTORS;

EID: 84855315374     PISSN: 09523480     EISSN: 10991492     Source Type: Journal    
DOI: 10.1002/nbm.1677     Document Type: Article

References (38)

1. Zhou J, van Zijl PC. Chemical exchange saturation transfer imaging and spectroscopy. Prog. Nucl. Magn. Reson. Spectrosc. 2006; 48: 109-136.
2. Sherry AD, Woods M. Chemical exchange saturation transfer contrast agents for magnetic resonance imaging. Annu. Rev. Biomed. Eng. 2008; 10: 391-411.
3. Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST). J. Magn. Reson. 2000; 143(1): 79-87.
4. Zhang S, Wu K, Sherry AD. Unusually sharp dependence of water exchange rate versus lanthanide ionic radii for a series of tetraamide complexes. J. Am. Chem. Soc. 2002; 124(16): 4226-4227.
5. Aime S, Barge A, Delli Castelli D, Fedeli F, Mortillaro A, Nielsen FU, Terreno E. Paramagnetic lanthanide(III) complexes as pH-sensitive chemical exchange saturation transfer (CEST) contrast agents for MRI applications. Magn. Reson. Med. 2002; 47(4): 639-648.
6. Aime S, Barge A, Gianolio E, Pagliarin R, Silengo L, Tei L. High relaxivity contrast agents for MRI and molecular imaging. Ernst Schering Res. Found. Workshop, 2005; 49: 99-121.
7. Zhang S, Sherry AD. Physical characteristics of lanthanide complexes that act as magnetization transfer (MT) contrast agents. J. Solid State Chem. 2003; 171(1-2): 38-43.
8. 3+-DOTAM-glycine (Gly)-phenylalanine (Phe). Magn. Reson. Med. 2008; 59(2): 374-381.
9. Zhang S, Malloy CR, Sherry AD. MRI thermometry based on PARACEST agents. J. Am. Chem. Soc. 2005; 127(50): 17 572-17 573.
10. Aime S, Delli Castelli D, Fedeli F, Terreno E. A paramagnetic MRI-CEST agent responsive to lactate concentration. J. Am. Chem. Soc. 2002; 124(32): 9364-9365.
11. Zhang S, Trokowski R, Sherry AD. A paramagnetic CEST agent for imaging glucose by MRI. J. Am. Chem. Soc. 2003; 125(50): 15 288-15 289.
12. Ren J, Trokowski R, Zhang S, Malloy CR, Sherry AD. Imaging the tissue distribution of glucose in livers using a PARACEST sensor. Magn. Reson. Med. 2008; 60(5): 1047-1055.
13. Dhingra K, Maier ME, Beyerlein M, Angelovski G, Logothetis NK. Synthesis and characterization of a smart contrast agent sensitive to calcium. Chem. Commun. (Camb.) 2008; 7(29): 3444-3446.
14. Esqueda AC, Lopez JA, Andreu-de-Riquer G, Alvarado-Monzon JC, Ratnakar J, Lubag AJ, Sherry AD, De Leon-Rodriguez LM. A new gadolinium-based MRI zinc sensor. J. Am. Chem. Soc. 2009; 131(32): 11 387-11 391.
15. Sherry AD, Caravan P, Lenkinski RE. Primer on gadolinium chemistry. J. Magn. Reson. Imaging, 2009; 30(6): 1240-1248.
16. Aime S, Botta M, Fasano M, Marques MP, Geraldes CF, Pubanz D, Merbach AE. Conformational and coordination equilibria on DOTA complexes of lanthanide metal ions in aqueous solution studied by (1)H-NMR spectroscopy. Inorg. Chem. 1997; 36(10): 2059-2068.
17. 5- complexes. A comparison of lanthanide-induced paramagnetic shifts with the MMX energy-minimized structure. J. Magn. Reson. 1992; 97(2): 290-304.
18. Sherry AD, Ren J, Huskens J, Brucher E, Toth E, Geraldes CFCG, Castro MMCA, Cacheris WP. Characterization of lanthanide(III) DOTP complexes: thermodynamics, protonation, and coordination to alkali metal ions. Inorg. Chem. 1996; 35(16): 4604-4612.
19. Pasha A, Lin M, Tircso G, Rostollan CL, Woods M, Kiefer GE, Sherry AD, Sun X. Synthesis and evaluation of lanthanide ion DOTA-tetraamide complexes bearing peripheral hydroxyl groups. J. Biol. Inorg. Chem. 2009; 14(3): 421-438.
20. 5-: a substance for NMR temperature measurements in vivo. Magn. Reson. Med. 1996; 36(6): 955-959.
21. 5- infusion. J. Magn. Reson. Imaging, 1992; 2(4): 385-391.
22. 1H-NMR in conjunction with a lanthanide complex. J. Appl. Physiol. 2003; 94(4): 1641-1649.
23. Coman D, Trubel HK, Rycyna RE, Hyder F. Brain temperature and pH measured by (1)H chemical shift imaging of a thulium agent. NMR Biomed. 2009; 22(2): 229-239.
24. -. NMR Biomed. 2010; 23(3): 277-285.
25. 1H-NMR thermometer suitable for cryoprobes. Magn. Reson. Chem. 2007; 45(2): 175-178.
26. Morton DW, Maravilla KR, Meno JR, Winn HR. Clinically relevant rat model for testing BOLD functional MR imaging techniques by using single-shot echo-planar imaging at 1.5T. Radiology, 2001; 218(2): 598-601.
27. Grad J, Bryant RG. Nuclear magnetic cross-relaxation spectroscopy. J. Magn. Reson. 1990; 90(1): 1-8.
28. Grad J, Mendelson D, Hyder F, Bryant RG. Applications of nuclear magnetic cross-relaxation spectroscopy to tissues. Magn. Reson. Med. 1991; 17(2): 452-459.
29. Bevington PR. Data Reduction and Error Analysis for the Physical Sciences. McGraw-Hill: New York, NY, 1969.
30. Dixon WT, Ren J, Lubag AJ, Ratnakar J, Vinogradov E, Hancu I, Lenkinski RE, Sherry AD. A concentration-independent method to measure exchange rates in PARACEST agents. Magn. Reson. Med. 2010; 63(3): 625-632.
31. Zhang S, Merritt M, Woessner DE, Lenkinski RE, Sherry AD. PARACEST agents: modulating MRI contrast via water proton exchange. Acc. Chem. Res. 2003; 36(10): 783-790.
32. Pikkemaat JA, Wegh RT, Lamerichs R, van de Molengraaf RA, Langereis S, Burdinski D, Raymond AY, Janssen HM, de Waal BF, Willard NP, Meijer EW, Grull H. Dendritic PARACEST contrast agents for magnetic resonance imaging. Contrast Media Mol. Imaging, 2007; 2(5): 229-239.
33. Vinogradov E, He H, Lubag A, Balschi JA, Sherry AD, Lenkinski RE. MRI detection of paramagnetic chemical exchange effects in mice kidneys in vivo. Magn. Reson. Med. 2007; 58(4): 650-655.
34. Trubel H, Herman P, Kampmann C, Novotny E, Hyder F. [Selective pharyngeal brain cooling]. Biomed. Tech. (Berl.) 2003; 48(11): 298-300.
35. Trubel H, Herman P, Kampmann C, Huth R, Maciejewski PK, Novotny E, Hyder F. A novel approach for selective brain cooling: implications for hypercapnia and seizure activity. Intensive Care Med. 2004; 30(9): 1829-1833.
36. Trubel H, Herman P, Kampmann C, Novotny E, Hyder F. [Duration of induced seizures during selective pharyngeal brain cooling]. Biomed. Tech. (Berl.) 2004; 49(10): 279-281.
37. Trubel HK, Sacolick LI, Hyder F. Regional temperature changes in the brain during somatosensory stimulation. J. Cereb. Blood Flow Metab. 2006; 26(1): 68-78.
38. Maandag NJ, Coman D, Sanganahalli BG, Herman P, Smith AJ, Blumenfeld H, Shulman RG, Hyder F. Energetics of neuronal signaling and fMRI activity. Proc. Natl. Acad. Sci. USA, 2007; 104(51): 20 546-20 551.