Imaging of the muscarinic acetylcholine neuroreceptor in rats with the M2 selective agonist [ 18F]FP-TZTP

Nuclear Medicine and Biology

Volumn 39, Issue 1, 2012, Pages 45-55

  Ravasi, Laura ^a,b   Tokugawa, Joji ^c   Nakayama, Toshiyuki ^e   Seidel, Jurgen ^f   Sokoloff, Louis ^e   Eckelman, William C ^a,d   Kiesewetter, Dale O ^a,c  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c NATIONAL INSTITUTE OF BIOMEDICAL IMAGING AND BIOENGINEERING   (United States)

^d Molecular Tracer LLC   (United States)

^e NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^f NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Agonist; Alzheimer's disease; Distribution ratios; Muscarinic receptor; Small animal PET scanner

Indexed keywords

3 [3 [(3 FLUOROPROPYL)THIO] 1,2,5 THIADIAZOL 4 YL] 1,2,5,6 TETRAHYDRO 1 METHYLPYRIDINE F 18; CHOLINERGIC RECEPTOR; ISOFLURANE; MUSCARINIC M2 RECEPTOR AGONIST; TRACER; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BIOCHEMISTRY; BLOOD SAMPLING; BLOOD VOLUME; BRAIN TISSUE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG METABOLISM; EX VIVO STUDY; IN VIVO STUDY; MALE; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; QUANTITATIVE ANALYSIS; RADIATION MEASUREMENT; RAT; REPRODUCIBILITY;

ACETYLCHOLINE; ANESTHETICS, INHALATION; ANIMALS; AUTORADIOGRAPHY; BRAIN; FLUORINE RADIOISOTOPES; ISOFLURANE; MALE; POSITRON-EMISSION TOMOGRAPHY; PYRIDINES; RADIONUCLIDE IMAGING; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; THIAZOLES; TISSUE DISTRIBUTION;

EID: 84855315118     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2011.06.003     Document Type: Article

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