Cytokine and protein markers of leprosy reactions in skin and nerves: Baseline results for the north indian infir cohort

PLoS Neglected Tropical Diseases

Volumn 5, Issue 12, 2011, Pages

  Lockwood, Diana N J ^a   Suneetha, Lavanya ^b   De Sagili, Karunavi ^b   van Chaduvula, Meheri ^b,c   Mohammed, Ismail ^b   van Brakel, Wim ^d   Smith, W C ^e   Nicholls, Peter ^f   Suneetha, Sujai ^b  

^a LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^b LEPRA Society   (India)

^c SAFDARJUNG HOSPITAL CAMPUS   (India)

^d ROYAL TROPICAL INSTITUTE   (Netherlands)

^e UNIVERSITY OF ABERDEEN   (United Kingdom)

^f UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER; CD68 ANTIGEN; CELL MARKER; CYTOKINE; EOSIN; HEMATOXYLIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MONOCLONAL ANTIBODY; PROTEIN S 100; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA; NOS2 PROTEIN, HUMAN;

ANTIBODY DETECTION; ARTICLE; BORDERLINE LEPROSY; CELL INFILTRATION; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE CLASSIFICATION; DISEASE MARKER; EPITHELIOID CELL; ERYTHEMA NODOSUM LEPROSUM; HISTOPATHOLOGIC SKIN REACTION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INDIAN; LEPROMATOUS LEPROSY; MACROPHAGE; MAJOR CLINICAL STUDY; MICROSCOPY; NERVE BIOPSY; NEURITIS; PROTEIN LOCALIZATION; SENSITIVITY AND SPECIFICITY; SKIN BIOPSY; SKIN GRANULOMA; TUBERCULOID LEPROSY; BIOPSY; IMMUNOLOGY; INDIA; LEPROSY; METABOLISM; PATHOLOGY; PERIPHERAL NERVE; REPRODUCIBILITY; SKIN;

BIOLOGICAL MARKERS; BIOPSY; COHORT STUDIES; CYTOKINES; HUMANS; IMMUNOHISTOCHEMISTRY; INDIA; LEPROSY; NITRIC OXIDE SYNTHASE TYPE II; PERIPHERAL NERVES; REPRODUCIBILITY OF RESULTS; SKIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855263752     PISSN: 19352727     EISSN: 19352735     Source Type: Journal    
DOI: 10.1371/journal.pntd.0001327     Document Type: Article

References (33)

1. Walker SL, Lockwood DN, (2008) Leprosy type 1 (reversal) reactions and their management. Lepr Rev 79: 372-386.
2. van Brakel WH, Nicholls PG, Das L, Barkataki P, Suneetha SK, et al. (2005) The INFIR Cohort Study: investigating prediction, detection and pathogenesis of neuropathy and reactions in leprosy. Methods and baseline results of a cohort of multibacillary leprosy patients in north India. Lepr Rev 76: 14-34.
3. van Brakel WH, Nicholls PG, Wilder-Smith EP, Das L, Barkataki P, et al. (2008) Early Diagnosis of Neuropathy in Leprosy-Comparing Diagnostic Tests in a Large Prospective Study (the INFIR Cohort Study). PLoS Negl Trop Dis 2: e212.
4. Little D, Khanolkar-Young S, Coulthart A, Suneetha S, Lockwood DN, (2001) Immunohistochemical analysis of cellular infiltrate and gamma interferon, interleukin-12, and inducible nitric oxide synthase expression in leprosy type 1 (reversal) reactions before and during prednisolone treatment. Infect Immun 69: 3413-3417.
5. Kahawita IP, Lockwood DN, (2008) Towards understanding the pathology of erythema nodosum leprosum. Trans R Soc Trop Med Hyg 102: 329-337.
6. Britton WJ, (1998) The management of leprosy reversal reactions. Lepr Rev 69: 225-234.
7. Hirsch CS, Yoneda T, Averill L, Ellner JJ, Toossi Z, (1994) Enhancement of intracellular growth of Mycobacterium tuberculosis in human monocytes by transforming growth factor-beta 1. J Infect Dis 170: 1229-1237.
8. Flesch IE, Hess JH, Kaufmann SH, (1994) NADPH diaphorase staining suggests a transient and localized contribution of nitric oxide to host defence against an intracellular pathogen in situ. Int Immunol 6: 1751-1757.
9. Kindler V, Sappino AP, Grau GE, Piguet PF, Vassalli P, (1989) The inducing role of tumor necrosis factor in the development of bactericidal granulomas during BCG infection. Cell 56: 731-740.
10. Saunders BM, Cooper AM, (2000) Restraining mycobacteria: role of granulomas in mycobacterial infections. Immunol Cell Biol 78: 334-341.
11. Yamamura M, Wang X-H, Ohmen JD, Uyemura K, Rea TH, et al. (1992) Cytokine patterns of immuniologically mediated tissue damage. J Immunol 149: 1470-1475.
12. Teles RM, Moraes MO, Geraldo NT, Salles AM, Sarno EN, et al. (2002) Differential TNFalpha mRNA regulation detected in the epidermis of leprosy patients. Arch Dermatol Res 294: 355-362.
13. Andersson AK, Chaduvula M, Atkinson SE, Khanolkar-Young S, Jain S, et al. (2005) Effects of prednisolone treatment on cytokine expression in patients with leprosy type 1 reactions. Infect Immun 73: 3725-3733.
14. Khanolkar-Young S, Rayment N, Brickell PM, Katz DR, Vinayakumar S, et al. (1995) Tumour necrosis factor-alpha (TNF-alpha) synthesis is associated with the skin and peripheral nerve pathology of leprosy reversal reactions. Clin Exp Immunol 99: 196-202.
15. Khanolkar-Young S, Snowdon D, Lockwood DN, (1998) Immunocytochemical localization of inducible nitric oxide synthase and transforming growth factor-beta (TGF-beta) in leprosy lesions. Clin Exp Immunol 113: 438-442.
16. Schon T, Hernandez-Pando RH, Negesse Y, Leekassa R, Sundqvist T, et al. (2001) Expression of inducible nitric oxide synthase and nitrotyrosine in borderline leprosy lesions. Br J Dermatol 145: 809-815.
17. Leprosy-global situation. Wkly Epidemiol Rec 75: 226-231(2000).
18. Omer FM, Kurtzhals JA, Riley EM, (2000) Maintaining the immunological balance in parasitic infections: a role for TGF-beta? Parasitol Today 16: 18-23.
19. Ruegemer JJ, Ho SN, Augustine JA, Schlager JW, Bell MP, et al. (1990) Regulatory effects of transforming growth factor-beta on IL-2- and IL-4-dependent T cell-cycle progression. J Immunol 144: 1767-1776.
20. Pardoux C, Asselin-Paturel C, Chehimi J, Gay F, Mami-Chouaib F, et al. (1997) Functional interaction between TGF-beta and IL-12 in human primary allogeneic cytotoxicity and proliferative response. J Immunol 158: 136-143.
21. Vodovotz Y, Bogdan C, Paik J, Xie QW, Nathan C, (1993) Mechanisms of suppression of macrophage nitric oxide release by transforming growth factor beta. J Exp Med 178: 605-613.
22. Modlin RL, Hofman FM, Taylor CR, Rea TH, (1983) T lymphocyte subsets in the skin lesions of patients with leprosy. J Am Acad Dermatol 8: 182-189.
23. Narayanan RB, Bhutani LK, Sharma AK, Nath I, (1983) T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies. Clin Exp Immunol 51: 421-429.
24. Narayanan RB, Laal S, Sharma AK, Bhutani LK, Nath I, (1984) Differences in predominant T cell phenotypes and distribution pattern in reactional lesions of tuberculoid and lepromatous leprosy. Clin Exp Immunol 55: 623-628.
25. Thomas MM, Jacob M, Chandi SM, George S, Pulimood S, et al. (1999) Role of S-100 staining in differentiating leprosy from other granulomatous diseases of the skin. Int J Lepr Other Mycobact Dis 67: 1-5.
26. Gupta SK, Nigam S, Mandal AK, Kumar V, (2006) S-100 as a useful auxiliary diagnostic aid in tuberculoid leprosy. J Cutan Pathol 33: 482-486.
27. Van Brakel WH, Nicholls PG, Das L, Barkataki P, Maddali P, et al. (2005) The INFIR Cohort Study: assessment of sensory and motor neuropathy in leprosy at baseline. Lepr Rev 76: 277-295.
28. Ridley DS, Jopling WH, (1966) Classification of leprosy according to immunity. A five-group system. Int J Lepr Other Mycobact Dis 34: 255-273.
29. Lockwood DN, Lucas SB, Desikan K, Ebenezer G, Suneetha S, et al. (2008) The histological diagnosis of leprosy Type 1 reactions: identification of key variables and an analysis of the process of histological diagnosis. J Clin Pathol.
30. Ridley DS, (1988) Pathogenesis of Leprosy and Related Diseases London Wright.
31. Lockwood DN, Sarno E, Smith WC, (2007) Classifying leprosy patients-searching for the perfect solution? Lepr Rev 78: 317-320.
32. Scollard DM, (2008) The biology of nerve injury in leprosy. Lepr Rev 79: 242-253.
33. Porichha D, Mukherjee A, Ramu G, (2004) Neural pathology in leprosy during treatment and surveillance. Lepr Rev 75: 233-241.