Role of S-100 staining in differentiating leprosy from other granulomatous diseases of the skin

International Journal of Leprosy and Other Mycobacterial Diseases

Volumn 67, Issue 1, 1999, Pages 1-5

  Thomas, Mathew M ^a   Jacob, Mary ^a   Chandi, Sushil M ^a   George, Soshamma ^a   Pulimood, Susanne ^a   Jeyaseelan, L ^a   Job, Charles K ^b  

^a CHRISTIAN MEDICAL COLLEGE   (India)

^b St Thomas Hospital   (India)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN S 100;

ADULT; ARTICLE; CLINICAL ARTICLE; DIFFERENTIATION; FEMALE; GRANULOMATOUS INFLAMMATION; HUMAN; IMMUNOCYTOCHEMISTRY; IMMUNOPEROXIDASE STAINING; LANGERHANS CELL; LEPROSY; MALE; MYCOBACTERIUM LEPRAE; NERVE INJURY; SCHWANN CELL; SKIN BIOPSY; SKIN DISEASE; SKIN NERVE; TUBERCULOID LEPROSY;

DIAGNOSIS, DIFFERENTIAL; GRANULOMA; HUMANS; IMMUNOHISTOCHEMISTRY; LEPROSY, TUBERCULOID; MYCOBACTERIUM LEPRAE; S100 PROTEINS; SARCOIDOSIS; SCHWANN CELLS; SKIN; TUBERCULOSIS, CUTANEOUS;

EID: 0032879063     PISSN: 0148916X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (17)

1. BONI, R., BURG, G., DOGNOGHU, A., ILG, E. C., SCHAFER, B. W., MULLER, B. and HEIZMANN, C. W. Immunohistochemical localization of the Ca2+ binding S-100 proteins in normal human skin and melanocytic lesion. Br. J. Dermatol. 137 (1997) 39-43.
2. CALISSANO, P., MOORE, B. W. and FRIESEN, A. Effect of calcium on S-100, a protein of the nervous system. Biochemistry 8 (1969) 4318-4326.
3. FINE, P. E. M., JOB, C. K., LUCAS, S. B., MEYERS, W. M., PONNIGHAUS, J. M. and STERNE, J. A. C. Extent, origin and implication of interobserver variation in the histopathological diagnosis of suspected leprosy. Int. J. Lepr. 61 (1993) 270-282.
4. FLUERY, R. N. and ARANDA, C. M. Detection of AFB in tuberculoid biopsies. (Letter) Int. J. Lepr. 63 (1995) 103.
5. FLEURY, R. N. and BACCHI, C. E. S-100 protein and immunoperoxidase technique as an aid in the histopathologic diagnosis of leprosy. Int. J. Lepr. 55 (1987) 338-344.
6. JACOB, M., CHACKO, C. J. G., ARUNTHATHI, S. and CHANDI, S. M. Significance and interpretation of nerve changes in skin biopsies when present in association with common dermatological conditions. (Abstract) Int. J. Lepr. 52 Suppl. (1984) 755.
7. JOB, C. K. Nerve damage in leprosy. (XIII Leprosy Congress State of the Art Lecture) Int. J. Lepr. 57 (1989) 532-539.
8. JOB, C. K. and CHACKO, C. J. G. A simplified six group classification of leprosy. Lepr. India 54 (1981) 14-16.
9. JOB, C. K., DRAIN, V., DEMING, A. T., HASTINGS, R. C. and GERBER, M. A. Role of S-100 protein as a marker for Schwann cells in the diagnosis of tuberculoid leprosy. (Letter) Int. J. Lepr. 58 (1990) 392-393.
10. KHAN, H. J., MARKS, A., THOM, H. R. T. and BAUMAI, R. Role of antibody to S-100 protein in diagnostic pathology. Am. J. Clin. Pathol. 79 (1983) 341-347.
11. MOORE, B. W. A soluble protein, characteristic of the nervous system. Biochem. Biophys. Res. Commun. 19 (1965) 739-744.
12. NARAYAN, R., MAHESWARI, P. K. and DESIKAN, K. V. Detection of S-100 protein and anticeramide antibodies in leprosy patients by ELISA. Lepr. Rev. 68 (1997) 117-124.
13. PONNIGHAUS, J. M., LEINHARDT, C., LUCAS, S., FINE, P. E. M. and STERNE, J. A. C. Comparison of bacillary indexes in slit skin smears, skin and nerve biopsies: a study from Malawi. Int. J. Lepr. 65 (1997) 211-216.
14. SCHAFER, B. W. and HEIZMANN, C. W. The S-100 family of EF-hand calcium binding proteins functions and pathology. Trends Biochem. Sci. 21 (1996) 134-140.
15. SEHGAL, V. N., REGE, V. L. and REY, M. Correlation between clinical and histopathological classification of leprosy. Int. J. Lepr. 45 (1977) 278-280.
16. SINGH, N., ARORA, V. K., RAMAM, M., TICKOO, S. K. and BHATIA, A. An evaluation of the S-100 stain in the histological diagnosis of tuberculoid leprosy and other granulomatous dermatoses. Int. J. Lepr. 62 (1994) 263-267.
17. WORLD HEALTH ORGANIZATION. Action Programme for the Elimination of Leprosy. Status Report. Geneva: World Health Organization, 1996.