Topology-selective chromatography reveals plasmid supercoiling shifts during fermentation and allows rapid and efficient preparation of topoisomers

Angewandte Chemie - International Edition

Volumn 51, Issue 1, 2012, Pages 267-270

  Mahut, Marek ^a   Haller, Elisabeth ^a   Ghazidezfuli, Parisa ^a   Leitner, Michael ^b   Ebner, Andreas ^b   Hinterdorfer, Peter ^b,c   Lindner, Wolfgang ^a   Lämmerhofer, Michael ^a,d  

^a Institute of Analytical Chemistry   (Austria)

^b JOHANNES KEPLER UNIVERSITY LINZ   (Austria)

^c Center for Advanced Bioanalysis (CBL)   (Austria)

^d UNIVERSITY OF TÜBINGEN   (Germany)

Author keywords

cinchona alkaloids; DNA structures; liquid chromatography; molecular recognition; plasmid topoisomers

Indexed keywords

CINCHONA ALKALOID; DNA STRUCTURES; PLASMID DNA; SUPERCOILED; SUPERCOILING; TOPOISOMERS; TWO-DIMENSIONAL HPLC;

DNA; FERMENTATION; MOLECULAR RECOGNITION; TOPOLOGY;

LIQUID CHROMATOGRAPHY;

ARTICLE; BIOSYNTHESIS; DNA SUPERCOILING; FERMENTATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOLATION AND PURIFICATION; ISOMERISM; PLASMID;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, SUPERHELICAL; FERMENTATION; ISOMERISM; PLASMIDS;

EID: 84855262910     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201106495     Document Type: Article

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