Current models and strategies in the development of antiobesity drugs

Annals of the New York Academy of Sciences

Volumn 1245, Issue 1, 2011, Pages 3-6

  Kinsey Jones, James S ^a   Murphy, Kevin G ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Animal model; Antiobesity; Obesity

Indexed keywords

ANTIOBESITY AGENT;

ARTICLE; DIETARY INTAKE; DRUG INDICATION; DRUG RESEARCH; ENERGY METABOLISM; GENETIC DISORDER; KNOCKOUT GENE; LIPID DIET; NONHUMAN; OBESITY; RODENT;

ANIMALIA;

EID: 84855237006     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1111/j.1749-6632.2011.06343.x     Document Type: Article

References (9)

1. World Health Organization. 2011. Obesity and overweight fact sheet No 311.
2. Kopelman, P.G. 2000. Obesity as a medical problem. Nature 404: 635-643.
3. Wadden, T.A., M.L. Butryn & C. Wilson 2007. Lifestyle modification for the management of obesity. Gastroenterology 132: 2226-2238.
4. Eckel, R.H., S.E. Kahn, E. Ferrannini, et al 2011. Obesity and type 2 diabetes: what can be unified and what needs to be individualized. J. Clin. Endocrinol. Metab. 96: 1654-1663.
5. Adam, T.C. & E.S. Epel 2007. Stress, eating and the reward system. Physiol. Behav. 91: 449-458.
6. Vickers, S.P., H.C. Jackson & S.C. Cheetham 2011. The utility of animal models to evaluate novel anti-obesity agents. Br. J. Pharmacol. 164: 1248-1262.
7. Smith, B.K., P.K. Andrews & D.B. West 2000. Macronutrient diet selection in thirteen mouse strains. Am. J. Physiol. Regul. Integr. Comp. Physiol. 278: R797-805.
8. Reed, D.R., M.P. Lawler & M.G. Tordoff 2008. Reduced body weight is a common effect of gene knockout in mice. BMC Genet. 9: 4.
9. Field, B.C., A.M. Wren, V. Peters, et al 2010. PYY3-36 and oxyntomodulin can be additive in their effect on food intake in overweight and obese humans. Diabetes 59: 1635-1639.