Variation in myxoid liposarcoma: Clinicopathological examination of four cases with detectable TLS-CHOP or EWS-CHOP fusion transcripts whose histopathological diagnosis was other than myxoid liposarcoma

Oncology Letters

Volumn 3, Issue 2, 2012, Pages 293-296

  Suzuki, Kayo ^a   Matsui, Yoshito ^a   Hashimoto, Nobuyuki ^b   Naka, Norifumi ^b   Araki, Nobuhito ^c   Kimura, Tomoatsu ^a   Yoshikawa, Hideki ^b   Ueda, Takafumi ^d  

^a UNIVERSITY OF TOYAMA   (Japan)

^b OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^d OSAKA NATIONAL HOSPITAL   (Japan)

Author keywords

Ewing sarcoma CCAAT enhancer binding homologous protein; Histopathology; Human translocation liposarcoma CCAAT enhancer binding homologous protein; Myxoid liposarcoma; Reverse transcription polymerase chain reaction; Variation

Indexed keywords

ANTINEOPLASTIC AGENT; EWS CHOP FUSION PROTEIN; GADOLINIUM PENTETATE; HYBRID PROTEIN; TLS CHOP FUSION PROTEIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER ADJUVANT THERAPY; CANCER CHEMOTHERAPY; CANCER DIAGNOSIS; CANCER RADIOTHERAPY; CASE REPORT; CELL DIFFERENTIATION; DIFFERENTIAL DIAGNOSIS; FEMALE; FUSION GENE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; MALE; MEDICAL RECORD; MONOPHASIC SYNOVIAL SARCOMA; MORPHOLOGY; MYXOSARCOMA; NUCLEAR MAGNETIC RESONANCE IMAGING; PLEOMORPHIC MALIGNANT FIBROUS HISTIOCYTOMA; PLEOMORPHIC SARCOMA; POSTOPERATIVE PERIOD; PROTEIN ANALYSIS; RETROPERITONEUM; SARCOMA; SOFT TISSUE SARCOMA; THIGH;

EID: 84855224496     PISSN: 17921074     EISSN: 17921082     Source Type: Journal    
DOI: 10.3892/ol.2011.480     Document Type: Article

References (14)

1. Weiss SW and Goldblum JR (eds): Liposarcoma. In: Enzinger and Weiss's Soft Tissue Tumors, 4th edition. Mosby, St. Louis, pp641-93, 2001.
2. Antonescu CR and Ladanyi M: Myxoid liposarcoma. In: World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Soft Tissue and Bone. Fletcher CDM, Unni KK and Mertens F (eds). IARC Press, Lyon, pp40-43, 2002.
3. Antonescu CR, Elahi A, Humphrey M, Lui MY, Healey JH, Brennan MF, Woodruff JM, Jhanwar SC and Ladanyi M: Specificity of TLS-CHOP rearrangement for classic myxoid/ round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas. J Mol Diagn 2: 132-138, 2000.
4. Panagopoulos I, Mertens F, Isaksson M and Mandahl N: A novel FUS/CHOP chimera in myxoid liposarcoma. Biochem Biophys Res Commun 279: 838-845, 2000.
5. Antonescu CR, Tschernyavsky SJ, Decuseara R, Leung DH, Woodruff JM, Brennan MF, Bridge JA, Neff JR, Goldblum JR and Ladanyi M: Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res 7: 3977-3987, 2001.
6. Hosaka T, Nakashima Y, Kusuzaki K, Murata H, Nakayama T, Nakamata T, Aoyama T, Okamoto T, Nishijo K, Araki N, et al: A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. J Mol Diagn 4: 164-171, 2002.
7. Domoto H, Hosaka T, Oikawa K, Ohbayashi T, Ishida T, Izumi M, Iwaya K, Toguchida J, Kuroda M and Mukai K: TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas. Pathol Int 52: 497-500, 2002.
8. Bode-Lesniewska B, Frigerio S, Exner U, Abdou MT, Moch H and Zimmermann DR: Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion. Genes Chromosomes Cancer 46: 961-971, 2007.
9. Alaggio R, Coffin CM, Weiss SW, Bridge JA, Issakov J, Oliveira AM and Folpe AL: Liposarcomas in young patients: a study of 82 cases occurring in patients younger than 22 years of age. Am J Surg Pathol 33: 645-658, 2009.
10. Kubo T, Matsui Y, Naka N, Araki N, Myoui A, Endo K, Yasui N, Ohtani O, Suzuki K, Kimura T, Yoshikawa H and Ueda T: Specificity of fusion genes in adipocytic tumors. Anticancer Res 30: 661-664, 2010.
11. Matsui Y, Ueda T, Kubo T, Hasegawa T, Tomita Y, Okamoto M, Myoui A, Kakunaga S, Yasui N and Yoshikawa H: A novel type of EWS-CHOP fusion gene in myxoid liposarcoma. Biochem Biophys Res Commun 348: 437-440, 2006.
12. Suzuki K, Matsui Y, Endo K, Kubo T, Hasegawa T, Kimura T, Ohtani O and Yasui N: Myxoid liposarcoma with EWS-CHOP type 1 fusion gene. Anticancer Res 30: 4679-4684, 2010.
13. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, Brennan MF, Bridge JA, Neff JR, Barr FG, et al: Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 62: 135-140, 2002.
14. De Vreeze RSA, De Jong D, Koops W, Nederlof PM, Ariaens A, Haas RL and van Coevorden F: Oncogenesis and classification of mixed-type liposarcoma: a radiological, histopathological and molecular biological analysis. Int J Cancer 128: 778-786, 2011.