Specificity of fusion genes in adipocytic tumors

Anticancer Research

Volumn 30, Issue 2, 2010, Pages 661-664

  Kubo, Takahiro ^a   Matsui, Yoshito ^b   Naka, Norifumi ^c   Araki, Nobuhito ^c   Myoui, Akira ^d   Endo, Kenji ^a   Yasui, Natsuo ^a   Ohtani, Osamu ^b   Suzuki, Kayo ^b   Kimura, Tomoatsu ^b   Yoshikawa, Hideki ^d   Ueda, Takafumi ^e  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b UNIVERSITY OF TOYAMA   (Japan)

^c OSAKA MEDICAL CENTER FOR CANCER AND CARDIOVASCULAR DISEASES   (Japan)

^d OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^e OSAKA NATIONAL HOSPITAL   (Japan)

Author keywords

Adipocytic tumors; EWS CHOP; HMGA2 LPP; Lipoma; Liposarcoma; LPP HMGA2; RT PCR; TLS CHOP

Indexed keywords

ARTICLE; CONTROLLED STUDY; EWS CHOP FUSION GENE; FUSION GENE; GENE EXPRESSION; HMGA2 LPP FUSION GENE; HUMAN; HUMAN TISSUE; LIPOMA; LIPOSARCOMA; MYXOSARCOMA; PRIORITY JOURNAL; TLS CHOP FUSION GENE;

CELL DIFFERENTIATION; HMGA PROTEINS; HUMANS; LIPOMA; LIPOSARCOMA; NEOPLASM STAGING; ONCOGENE PROTEINS, FUSION; PROGNOSIS; RETROSPECTIVE STUDIES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; TRANSCRIPTION FACTOR CHOP;

EID: 77950537448     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. Fletcher CDM, Unni KK and Mertens F (eds.): World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone. IARC Press: Lyon, 2002.
2. Ashar HR, Schoenberg Fejzo M, Tkachenko A, Zhou X, Fletcher JA, Weremowics S, Morton CC and Chada K: Disruption of the architectural factor HMGI-C: DNA-binding AT hook motifs fused in lipomas to distinct transcriptional regulatory domains. Cell 82: 57-65, 1995.
3. Schoenmakers EF, Wanschura S, Mols R, Bullerdiek J, Van den Berghe H and Van de Ven WJM: Recurrent rearrangements in the high mobility group protein gene, HMGI-C, in benign mesenchymal tumours. Nat Genet 10: 436-444, 1995.
4. Petit MM, Mols R, Schoenmakers EF, Mandahl N and Van de Ven WJ: LPP, the preferred fusion partner gene of HMGIC in lipomas, is a novel member of the LIM protein gene family. Genomics 36: 118-129, 1996.
5. Matsui Y, Hasegawa T, Kubo T, Goto T, Yukata K, Endo K, Bando Y and Yasui N: Intrapatellar tendon lipoma with chondroosseous differentiation: detection of HMGA2-LPP fusion gene transcript. J Clin Pathol 59: 434-436, 2006.
6. Kubo T, Matsui Y, Goto T, Yukata K, Endo K, Sato R, Tsutsui T and Yasui N: MRI characteristics of parosteal lipomas associated with the HMGA2-LPP fusion gene. Anticancer Res 26: 2253-2257, 2006.
7. Ida CM, Wang X, Erickson-Johnson MR, Wenger DE, Blute ML, Nascimento AG and Oliveira AM: Primary retroperitoneal lipoma: a soft tissue pathology heresy? Report of a case with classic histologic, cytogenetics, and molecular genetic features. Am J Surg Pathol 32: 951-954, 2008.
8. Petit MMR, Swarts S, Bridge JA and Van de Ven WJM: Expression of reciprocal fusion transcripts of the HMGIC and LPP genes in parosteal lipoma. Cancer Genet Cytogenet 106: 18-23, 1998.
9. Kubo T, Matsui Y, Naka N, Araki N, Goto T, Yukata K, Endo K, Yasui N, Myoui A, Kawabata H, Yoshikawa H and Ueda T: Expression of HMGA2-LPP and LPP-HMGA2 fusion genes in lipoma: identification of a novel type of LPP-HMGA2 transcript in four cases. Anticancer Res 29: 2357-2360, 2009.
10. Hatano H, Morita T, Ogose A, Hotta T, Kobayashi H, Segawa H, Uchiyama T, Takenouchi T and Sato T: Clinicopathological features of lipomas with gene fusions involving HMGA2. Anticancer Res 28: 535-538, 2008.
11. Antonescu CR, Tschernyavsky SJ, Decuseara R, Leung DH, Woodruff JM, Brennan MF, Bridge JA, Neff JR, Goldblum JR and Ladanyi: Prognostic impact of P53 status, TLS-CHOP fusion transcript structure, and histological grade in myxoid liposarcoma: a molecular and clinicopathologic study of 82 cases. Clin Cancer Res 7: 3977-3987, 2001.
12. Antonescu CR, Elahi A, Humphrey M, Lui MY, Healey JH, Brennan MF, Woodruff JM, Jhanwar SC and Ladanyi M: Specificity of TLS-CHOP rearrangement for classic myxoid/ round cell liposarcoma: absence in predominantly myxoid well-differentiated liposarcomas. J Mol Diagn 2: 132-138, 2000.
13. Domoto H, Hosaka T, Oikawa K, Ohbayashi T, Ishida T, Izumi M, Iwaya K, Toguchida J, Kuroda M and Mukai K: TLS-CHOP target gene DOL54 expression in liposarcomas and malignant fibrous histiocytomas. Pathol Int 52: 497-500, 2002.
14. von Ahsen I, Rogalla P and Bullerdiek J: Expression patterns of the LPP-HMGA2 fusion transcript in pulmonary chondroid hamartomas with t(3;12)(q27 approximately 28;q14 approximately 15). Cancer Genet Cytogenet 163: 68-70, 2005.
15. Hosaka T, Nakashima Y, Kusuzaki K, Murata H, Nakayama T, Nakamata T, Aoyama T, Okamoto T, Nishijo K, Araki N, Tsuboyama T, Nakamura T and Toguchida J: A novel type of EWS-CHOP fusion gene in two cases of myxoid liposarcoma. J Mol Diagn 4: 164-171, 2002.
16. Panagopoulos I, Mertens F, Isaksson M and Mandahl N: A novel FUS/CHOP chimera in myxoid liposarcoma. Biochem Biophys Res Commun 279: 838-845, 2000.
17. Matsui Y, Ueda T, Kubo T, Hasegawa T, Tomita Y, Okamoto M, Myoui A, Kakunaga S, Yasui N and Yoshikawa H: A novel type of EWS-CHOP fusion gene in myxoid liposarcoma. Biochem Biophys Res Commun 348: 437-440, 2006.
18. Bode-Lesniewska B, Frigerio S, Exner U, Abdou MT, Moch H and Zimmermann DR: Relevance of translocation type in myxoid liposarcoma and identification of a novel EWSR1-DDIT3 fusion. Genes Chromosomes Cancer 46: 961-971, 2007.
19. Dahlen A, Mertens F, Rydholm A, Brosjo O, Wejde J, Mandahl N and Panagopoulos I: Fusion, disruption, and expression of HMGA2 in bone and soft tissue chondromas. Mod Pathol 16: 1132-1140, 2003.