Association between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer

Indian Journal of Gastroenterology

Volumn 30, Issue 6, 2011, Pages 257-263

  Tripathi, Shweta ^a   Ghoshal, Ujjala ^a   Mittal, Balraj ^a   Chourasia, Dipti ^a   Kumar, Sunil ^a   Ghoshal, Uday C ^a  

^a SANJAY GANDHI POSTGRADUATE INSTITUTE OF MEDICAL SCIENCES   (India)

Author keywords

Detoxification; Gastric neoplasm; Genetic polymorphism; GST enzyme activity; Host factor

Indexed keywords

GLUTATHIONE TRANSFERASE;

ADULT; ARTICLE; CANCER PATIENT; CONTROLLED STUDY; DNA POLYMORPHISM; DYSPEPSIA; ENZYME ACTIVITY; FEMALE; GENE; GENE DELETION; GENETIC ASSOCIATION; GENOTYPE; GSTM1 GENE; GSTP1 GENE; GSTT1 GENE; HELICOBACTER INFECTION; HELICOBACTER PYLORI; HUMAN; HUMAN TISSUE; MAJOR CLINICAL STUDY; MALE; PEPTIC ULCER; PROTEIN FUNCTION; STOMACH BIOPSY; STOMACH CANCER;

ADULT; AGED; BIOPSY; FEMALE; GASTRIC MUCOSA; GLUTATHIONE TRANSFERASE; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; MALE; METABOLIC DETOXICATION, PHASE II; MIDDLE AGED; ODDS RATIO; PEPTIC ULCER; POLYMORPHISM, GENETIC; STOMACH NEOPLASMS;

EID: 84855208108     PISSN: 02548860     EISSN: 09750711     Source Type: Journal    
DOI: 10.1007/s12664-011-0144-2     Document Type: Article

References (25)

1. Correa P. Human gastric carcinogenesis: a multistep and multifactorial process-First American Cancer Society Award Lecture on cancer epidemiology and prevention. Cancer Res. 1992; 52: 6735-40.
2. International Agency for Research on Cancer. In: Liver flukes and helicobacter pylori. IARC monographs on the evaluation of carcinogenic risks to human no. 61. Lycon: IARC; 1994.
3. Graham DY, Adam E, Reddy GT, et al. Seroepidemiology of helicobacter pylori infection in India. Comparison of developing and developed countries. Dig Dis Sci. 1991; 36: 1084-8.
4. Parsonnet J, Friedman GD, Orentreich N, Vogelman H. Risk for gastric cancer in people with CagA positive or CagA negative helicobacter pylori infection. Gut. 1997; 40: 297-301.
5. Singh K, Ghoshal UC. Causal role of Helicobacter pylori in gastric cancer: an Asian enigma. World J Gastroenterol. 2006; 12: 1346-51.
6. Ghoshal UC, Tiwari S, Dhingra S, et al. Frequency of Helicobacter pylori and CagA antibody in patients with gastric neoplasms and controls: the Indian enigma. Dig Dis Sci. 2008; 53: 1215-22.
7. Ghoshal UC, Tripathi S, Ghoshal U. The Indian enigma of frequent H. pylori infection but infrequent gastric cancer: is the magic key in Indian diet, host's genetic make up, or friendly bug? Am J Gastroenterol. 2007; 102: 2113-4.
8. González CA, Sala N, Capellá G. Genetic susceptibility and gastric cancer risk. Int J Cancer. 2002; 100: 249-60.
9. Dong LM, Potter JD, White E, Ulrich CM, Cardon LR, Peters U. Genetic susceptibility to cancer: the role of polymorphisms in candidate genes. JAMA. 2008; 299: 2423-36.
10. Gonzalez FJ. The role of carcinogen-metabolizing enzyme polymorphisms in cancer susceptibility. Reprod Toxicol. 1997; 11: 397-412.
11. Ketterer B. Protective role of glutathione and glutathione transferases in mutagenesis and carcinogenesis. Mutat Res. 1988; 202: 343-61.
12. Hayes JD, Pulford DJ. The glutathione S-transferase supergene family: regulation of GST and the contribution of the isoenzymes to cancer chemoprotection and drug resistance. Crit Rev Biochem Mol Biol. 1995; 30: 445-600.
13. Pemble S, Schroeder KR, Spencer SR, et al. Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J. 1994; 300(Pt 1): 271-6.
14. Ali-Osman F, Akande O, Antoun G, Mao JX, Buolamwini J. Molecular cloning, characterization, and expression in Escherichia coli of full-length cDNAs of three human glutathione S-transferase Pi gene variants. Evidence for differential catalytic activity of the encoded proteins. J Biol Chem. 1997; 272: 10004-12.
15. Tripathi S, Ghoshal U, Ghoshal UC, et al. Gastric carcinogenesis: possible role of polymorphisms of GSTM1, GSTT1, and GSTP1 genes. Scand J Gastroenterol. 2008; 43: 431-9.
16. You WC, Hong JY, Zhang L, et al. Genetic polymorphisms of CYP2E1, GSTT1, GSTP1, GSTM1, ALDH2, and ODC and the risk of advanced precancerous gastric lesions in a Chinese population. Cancer Epidemiol Biomarkers Prev. 2005; 14: 451-8.
17. Colombo J, Rossit AR, Caetano A, Borim AA, Wornrath D, Silva AE. GSTT1, GSTM1 and CYP2E1 genetic polymorphisms in gastric cancer and chronic gastritis in a Brazilian population. World J Gastroenterol. 2004; 10: 1240-5.
18. Martinez C, Martín F, Fernández JM, et al. Glutathione S-transferases mu 1, theta 1, pi 1, alpha 1 and mu 3 genetic polymorphisms and the risk of colorectal and gastric cancers in humans. Pharmacogenomics. 2006; 7: 711-8.
19. Tamer LA, Ateş NA, Ateş C, et al. Glutathione S-transferase M1, T1 and P1 genetic polymorphisms, cigarette smoking and gastric cancer risk. Cell Biochem Funct. 2005; 23: 267-72.
20. Verhulst ML, van Oijen AH, Roelofs HM, Peters WH, Jansen JB. Antral glutathione concentration and glutathione S-transferase activity in patients with and without Helicobacter pylori. Dig Dis Sci. 2000; 45: 629-32.
21. Beil W, Obst B, Sewing KF, Wagner S. Helicobacter pylori reduces intracellular glutathione in gastric epithelial cells. Dig Dis Sci. 2000; 45: 1769-73.
22. Habig WH, Pabst MJ, Jakoby WB. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J Biol Chem. 1974; 249: 7130-9.
23. Peters WH, Roelofs HM, Hectors MP, Nagengast FM, Jansen JB. Glutathione and glutathione S-transferases in Barrett's epithelium. Br J Cancer. 1993; 67: 1413-7.
24. Oijen AH, Verhulst ML, Roelofs HM, Peters WH, de Boer WA, Jansen JB. Eradication of Helicobacter pylori restores glutathione S-transferase activity and glutathione levels in antral mucosa. Jpn J Cancer Res. 2001; 92: 1329-34.
25. Hoensch H, Morgenstern I, Petereit G, Siepmann M, Peters WH, Roelofs HM, et al. Influence of clinical factors, diet, and drugs on the human upper gastrointestinal glutathione system. Gut. 2002; 50: 235-40.