Validation of the dimensionality emergence assay for the measurement of innate anxiety in laboratory mice

European Neuropsychopharmacology

Volumn 22, Issue 2, 2012, Pages 153-163

  Jain, Apar ^a   Dvorkin, Anna ^b   Fonio, Ehud ^b   Golani, Ilan ^b   Gross, Cornelius T ^a  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY EMBL   (Italy)

^b TEL AVIV UNIVERSITY   (Israel)

Author keywords

Anxiety; Diazepam; Dimensionality emergence assay; Mice; Open field

Indexed keywords

DIAZEPAM; SEROTONIN 1A RECEPTOR;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANXIETY; ARTICLE; BEHAVIORAL RESEARCH; CAGE; CONTROLLED STUDY; DOSE RESPONSE; INNATE ANXIETY; KNOCKOUT MOUSE; LABORATORY TEST; MALE; MOUSE; NONHUMAN; OPEN FIELD TEST; PRIORITY JOURNAL; VALIDATION PROCESS;

ANALYSIS OF VARIANCE; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; EXPLORATORY BEHAVIOR; LOCOMOTION; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; REACTION TIME; RECEPTOR, SEROTONIN, 5-HT1A; TIME FACTORS; TREATMENT OUTCOME;

EID: 84855205359     PISSN: 0924977X     EISSN: 18737862     Source Type: Journal    
DOI: 10.1016/j.euroneuro.2011.07.001     Document Type: Article

References (32)

1. Adhikari A., Topiwala M.A., Gordon J.A. Synchronized activity between the ventral hippocampus and the medial prefrontal cortex during anxiety. Neuron 2010, 65(2):257-269.
2. Blois-Heulin C., Belzung C. Effects of previous familiarization on novelty reactions in mice (Mus musculus). Behav. Processes 1995, 34:197-212.
3. Chaouloff F., Durand M., Mormède P. Anxiety- and activity-related effects of diazepam and chlordiazepoxide in the rat light/dark and dark/light tests. Behav. Brain Res. 1997, 85(1):27-35.
4. Christmas A.J., Maxwell D.R. A comparison of the effects of some benzodiazepines and other drugs on aggressive and exploratory behaviour in mice and rats. Neuropharmacology 1970, 1:17-29.
5. Cigrang M., Vogel E., Misslin R. Reduction of neophobia in mice following lesions of the caudate-putamen. Physiol. Behav. 1986, 36(1):25-28.
6. Crawley J.N. Neuropharmacologic specificity of a simple animal model for the behavioral actions of benzodiazepines. Pharmacol. Biochem. Behav. 1981, 5:695-699.
7. Crawley J.N. Exploratory behavior models of anxiety in mice. Neurosci. Biobehav. Rev. 1985, 9(1):37-44.
8. Crawley J.N., Goodwin F.K. Preliminary report of a simple animal behaviour for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav. 1980, 13:167-170.
9. Drai D., Benjamini Y., Golani I. Statistical discrimination of natural modes of motion in rat exploratory behavior. J. Neurosci. Methods 2000, 96:119-131.
10. Everitt B.S., Hand D.J. Finite Mixture Distributions 1981, Chapman & Hall, London.
11. Flint J., Corley R., DeFries J.C., Fulker D.W., Gray J.A., Miller S., Collins A.C. A simple generic basis for a complex psychological trait in laboratory mice. Science 1995, 269:1432-1435.
12. Fonio E., Benjamini Y., Golani I. Freedom of movement and the stability of its unfolding in free exploration of mice. Proc. Natl. Acad. Sci. U. S. A. 2009, 106(50):21335-21340.
13. Golani I., Benjamini Y., Eilam D. Stopping behavior: constraints on exploration in rats (Rattus norvegicus). Behav. Brain Res. 1993, 53:21-33.
14. Gordon J.A., Lacefield C.O., Kentros C.G., Hen R. State-dependent alterations in hippocampal oscillations in serotonin 1A receptor-deficient mice. J. Neurosci. 2005, 25(28):6509-6519.
15. Griebel G., Belzung C., Misslin R., Vogel E. The free-exploratory paradigm: an effective method for measuring neophobic behaviour in mice and testing potential neophobia-reducing drugs. Behav. Pharmacol. 1993, 4(6):637-644.
16. Gross C., Zhuang X., Stark K., Ramboz S., Oosting R., Kirby L., Santarelli L., Beck S., Hen R. Serotonin1A receptor acts during development to establish normal anxiety-like behaviour in the adult. Nature 2002, 416(6879):396-400.
17. Hajós M., Hoffmann W.E., Orbán G., Kiss T., Erdi P. Modulation of septo-hippocampal Theta activity by GABAA receptors: an experimental and computational approach. Neuroscience 2004, 126(3):599-610.
18. Heisler L.K., Chu H.M., Brennan T.J., Danao J.A., Bajwa P., Parsons L.H., Tecott L.H. Elevated anxiety and antidepressant-like responses in serotonin 5-HT1A receptor mutant mice. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(25):15049-15054.
19. Hen I., Sakov A., Kafkafi N., Golani I., Benjamini Y. The dynamics of spatial behavior: how can robust smoothing techniques help?. J. Neurosci. Methods 2004, 133:161-172.
20. Kafkafi N., Lipkind D., Benjamini Y., Mayo C.L., Elmer G.I. SEE locomotor behavior test discriminates C57BL/6J and DBA/2J mouse inbred strains across laboratories and protocol conditions. Behav. Neurosci. 2003, 117:464-477.
21. Lipkind D., Sakov A., Kafkafi N., Elmer G.I., Benjamini Y., Golani I. New replicable anxiety-related measures of wall vs. center behavior of mice in the open field. J. Appl. Physiol. 2004, 97(1):347-359.
22. Lister R.G. Ethologically-based animal models of anxiety disorders. Pharmacol. Ther. 1990, 46:321-340.
23. Marriott A.S., Smith E.F. An analysis of drug effects in mice exposed to a simple novel environment. Psychopharmacologia 1972, 24(3):397-406.
24. Nagy M.Z., Forest E.J. Open-field behavior of C3H mice. Effect of size and illumination of field. Psychon. Sci. 1970, 20:19-21.
25. Nagy Z., Glaser D.N. Open-field behavior of C57BL/6J mice: effect of illumination, age, and number of test day. Psychon. Sci. 1970, 19:143-145.
26. Paré W.P., Tejani-Butt S., Kluczynski J. The emergence test: effects of psychotropic drugs on neophobic disposition in Wistar Kyoto (WKY) and Sprague Dawley rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 2001, 8:1615-1628.
27. Parks C.L., Robinson P.S., Sibille E., Shenk T., Toth M. Increased anxiety of mice lacking the serotonin1A receptor. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(18):10734-10739.
28. Prickaerts J., Raaijmakers W., Blokland A. Effects of myocardial infarction and captopril therapy on anxiety-related behaviors in the rat. Physiol. Behav. 1996, 60(1):43-50.
29. Ramboz S., Oosting R., Amara D.A., Kung H.F., Blier P., Mendelsohn M., Mann J.J., Brunner D., Hen R. Serotonin receptor 1A knockout: an animal model of anxiety-related disorder. Proc. Natl. Acad. Sci. U. S. A. 1998, 95(24):14476-14481.
30. Stone C.P. Wildness and Savageness in Rats of Different Strains 1932, 1-55. Studies in the Dynamics of BehaviorUniversity of Chicago Press, Chicago. K.S. Lashley (Ed.).
31. Treit D., Fundytus M. Thigmotaxis as a test for anxiolytic activity in rats. Pharmacol. Biochem. Behav. 1988, 4:959-962.
32. van der Klejin E., van Rossum J.M., Muskens E.T., Rijntjes N.V. Pharmacokinetics of diazepam in dogs, mice and humans. Acta. Pharmacol. Toxicol. (Copenh) 1971, 29(Suppl. 3):109-127.