Discovery of pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 69-85

  Kendall, Jackie D ^a,b   O'Connor, Patrick D ^a   Marshall, Andrew J ^a   Frédérick, Raphaël ^a,c   Marshall, Elaine S ^a   Lill, Claire L ^b   Lee, Woo Jeong ^b   Kolekar, Sharada ^b   Chao, Mindy ^b   Malik, Alisha ^b   Yu, Shuqiao ^b   Chaussade, Claire ^b,d   Buchanan, Christina ^b   Rewcastle, Gordon W ^a,b   Baguley, Bruce C ^a,b   Flanagan, Jack U ^a,b   Jamieson, Stephen M F ^a,b   Denny, William A ^a,b   Shepherd, Peter R ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF NAMUR   (Belgium)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

p110 ; PI3 kinase; PI3K; PIK3CA; Pyrazolo 1,5 a pyridine; Sulfonohydrazide

Indexed keywords

4 METHOXYPYRIDINE; ACETIC ACID; ACETONE; ALDEHYDE; ALKENE DERIVATIVE; ALKYNE; AMIDE; ANTINEOPLASTIC AGENT; CARBOXYLIC ACID; CYCLOPROPANE; DIAZOMETHANE; ETHYLPYRAZOLO[1,5 A]PYRIDIN 3 CARBOXYLATE 3; HYDRAZIDE DERIVATIVE; IMIDAZO[1,5 A]PYRIDINE; ISONICOTINIC ACID; ISONICOTINIC ACID METHYL ESTER; ISONICOTINONITRILE; NITRILE; PHENOL; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PIK 75; PROTEIN KINASE B; PROTEIN P110; PROTEIN P110ALPHA; PYRAZO[1,5 A]PYRIDINE DERIVATIVE; PYRIDINE DERIVATIVE; SULFONOHYDRAZIDE DERIVATIVE; TERT BUTYL PYRIDIN 4 YLCARBAMATE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IC 50; IN VIVO STUDY; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; DRUG EVALUATION, PRECLINICAL; ENZYME ACTIVATION; HUMANS; MICE; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; PYRIDINES; TRANSPLANTATION, HETEROLOGOUS;

EID: 84855202660     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.029     Document Type: Article

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