Novel pyrazolo[1,5-a]pyridines as p110α-selective PI3 kinase inhibitors: Exploring the benzenesulfonohydrazide SAR

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 58-68

  Kendall, Jackie D ^a,b   Giddens, Anna C ^a   Tsang, Kit Yee ^a,c   Frédérick, Raphaël ^a,d   Marshall, Elaine S ^a   Singh, Ripudaman ^a   Lill, Claire L ^b   Lee, Woo Jeong ^b   Kolekar, Sharada ^b   Chao, Mindy ^b   Malik, Alisha ^b   Yu, Shuqiao ^b   Chaussade, Claire ^b,e   Buchanan, Christina ^b   Rewcastle, Gordon W ^a,b   Baguley, Bruce C ^a,b   Flanagan, Jack U ^a,b   Jamieson, Stephen M F ^a,b   Denny, William A ^a,b   Shepherd, Peter R ^b  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF HONG KONG   (Hong Kong)

^d UNIVERSITY OF NAMUR   (Belgium)

^e QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

p110 ; PI3 kinase; PI3K; PIK3CA; Pyrazolo 1,5 a pyridine; Sulfonohydrazide

Indexed keywords

ACYLHYUDRAZIDE DERIVATIVE; ALDEHYDE; ANTINEOPLASTIC AGENT; BENZENESULFONOHYDRAZIDE; HYDRAZIDE; HYDRAZONE DERIVATIVE; HYDROXYETHYL COMPOUND; N BENZYL N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N ETHYL 2 METHYL 5 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] 2 METHYL 5 NITRO N [2 (PIPERIDINE 1 YL)ETHYL]BENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N [2 (DIMETHYLAMINO)ETHYL] 2 METHYL 5 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N ETHYL 2 METHYL 5 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N,2 DIMETHYL 3 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N,2 DIMETHYL 4 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N,2 DIMETHYL 6 NITROBENZENESULFONOHYDRAZIDE; N' [(5 CYANOPYRAZOLO[1,5 A]PYRIDIN 3 YL)METHYLENE] N,2 DIMETHYLBENZENESULFONOHYDRAZIDE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PROTEIN P110; PROTEIN P110ALPHA; PYRAZO[1,5 A]PYRIDINE DERIVATIVE; SULFONOHYDRAZIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; CONTROLLED STUDY; DRUG DESIGN; DRUG HALF LIFE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TOLERABILITY; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HUMAN; HUMAN CELL; IN VIVO STUDY; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NONHUMAN; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; TUMOR XENOGRAFT;

ANIMALS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; COMPUTER SIMULATION; HUMANS; MICE; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; PYRAZOLES; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSPLANTATION, HETEROLOGOUS;

EID: 84855202236     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.031     Document Type: Article

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