Etomidate and mortality in cirrhotic patients with septic shock

BMC Clinical Pharmacology

Volumn 11, Issue , 2011, Pages

  Cherfan, Antoine J ^a   Tamim, Hani M ^b   AlJumah, Abdulrahman ^a   Rishu, Asgar H ^a   Al Abdulkareem, Abdulmajeed ^a   Al Knawy, Bandar A ^a   Hajeer, Ali ^b   Tamimi, Waleed ^a   Brits, Riette ^a   Arabi, Yaseen M ^a  

^a KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

^b KING SAUD BIN ABDULAZIZ UNIVERSITY FOR HEALTH SCIENCES   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

ETOMIDATE; HYDROCORTISONE; HYPERTENSIVE FACTOR; PLACEBO; VASOCONSTRICTOR AGENT;

ADULT; ARTICLE; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; CORTICOSTEROID THERAPY; DOUBLE BLIND PROCEDURE; FEMALE; HUMAN; INTENSIVE CARE; INTUBATION; LIVER CIRRHOSIS; LOW DRUG DOSE; MALE; MORTALITY; RANDOMIZED CONTROLLED TRIAL; SEPTIC SHOCK; SINGLE DRUG DOSE; CHEMICALLY INDUCED DISORDER; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; FIBROSIS; INTENSIVE CARE UNIT; METHODOLOGY; MIDDLE AGED; TREATMENT OUTCOME;

COHORT STUDIES; DOUBLE-BLIND METHOD; ETOMIDATE; FEMALE; FIBROSIS; HOSPITAL MORTALITY; HUMANS; HYDROCORTISONE; INTENSIVE CARE UNITS; INTUBATION; MALE; MIDDLE AGED; SHOCK, SEPTIC; TREATMENT OUTCOME; VASOCONSTRICTOR AGENTS;

EID: 84855180793     PISSN: None     EISSN: 14726904     Source Type: Journal    
DOI: 10.1186/1472-6904-11-22     Document Type: Article

References (44)

1. McCollum JS, Dundee JW. Comparison of induction characteristics of four intravenous anaesthetic agents. Anaesthesia 1986, 41(10):995-1000.
2. Benson M, Junger A, Fuchs C, Quinzio L, Bottger S, Hempelmann G. Use of an anesthesia information management system (AIMS) to evaluate the physiologic effects of hypnotic agents used to induce anesthesia. J Clin Monit Comput 2000, 16(3):183-190.
3. Doenicke A. Etomidate, a new intravenous hypnotic. Acta Anaesthesiol Belg 1974, 25(3):307-315.
4. Sivilotti ML, Filbin MR, Murray HE, Slasor P, Walls RM. Does the sedative agent facilitate emergency rapid sequence intubation?. Acad Emerg Med 2003, 10(6):612-620.
5. Wagner RL, White PF, Kan PB, Rosenthal MH, Feldman D. Inhibition of adrenal steroidogenesis by the anesthetic etomidate. N Engl J Med 1984, 310(22):1415-1421.
6. Duthie DJ, Fraser R, Nimmo WS. Effect of induction of anaesthesia with etomidate on corticosteroid synthesis in man. Br J Anaesth 1985, 57(2):156-159.
7. Absalom A, Pledger D, Kong A. Adrenocortical function in critically ill patients 24 h after a single dose of etomidate. Anaesthesia 1999, 54(9):861-867.
8. Watt I, Ledingham IM. Mortality amongst multiple trauma patients admitted to an intensive therapy unit. Anaesthesia 1984, 39(10):973-981.
9. Lamberts SW, Bons EG, Bruining HA, de Jong FH. Differential effects of the imidazole derivatives etomidate, ketoconazole and miconazole and of metyrapone on the secretion of cortisol and its precursors by human adrenocortical cells. J Pharmacol Exp Ther 1987, 240(1):259-264.
10. Cotton BA, Guillamondegui OD, Fleming SB, Carpenter RO, Patel SH, Morris JA, Arbogast PG. Increased risk of adrenal insufficiency following etomidate exposure in critically injured patients. Arch Surg 2008, 143(1):62-67. discussion 67.
11. Mohammad Z, Afessa B, Finkielman JD. The incidence of relative adrenal insufficiency in patients with septic shock after the administration of etomidate. Crit Care 2006, 10(4):R105.
12. Malerba G, Romano-Girard F, Cravoisy A, Dousset B, Nace L, Levy B, Bollaert PE. Risk factors of relative adrenocortical deficiency in intensive care patients needing mechanical ventilation. Intensive Care Med 2005, 31(3):388-392.
13. Lipiner-Friedman D, Sprung CL, Laterre PF, Weiss Y, Goodman SV, Vogeser M, Briegel J, Keh D, Singer M, Moreno R, et al. Adrenal function in sepsis: the retrospective Corticus cohort study. Crit Care Med 2007, 35(4):1012-1018.
14. Riche FC, Boutron CM, Valleur P, Berton C, Laisne MJ, Launay JM, Chappuis P, Peynet J, Vicaut E, Payen D, et al. Adrenal response in patients with septic shock of abdominal origin: relationship to survival. Intensive Care Med 2007, 33(10):1761-1766.
15. Bloomfield R, Noble DW. Corticosteroids for septic shock--a standard of care?. Br J Anaesth 2004, 93(2):178-180.
16. Hildreth AN, Mejia VA, Maxwell RA, Smith PW, Dart BW, Barker DE. Adrenal suppression following a single dose of etomidate for rapid sequence induction: a prospective randomized study. J Trauma 2008, 65(3):573-579.
17. Cuthbertson BH, Sprung CL, Annane D, Chevret S, Garfield M, Goodman S, Laterre PF, Vincent JL, Freivogel K, Reinhart K, et al. The effects of etomidate on adrenal responsiveness and mortality in patients with septic shock. Intensive Care Med 2009, 35(11):1868-1876.
18. Ray DC, McKeown DW. Effect of induction agent on vasopressor and steroid use, and outcome in patients with septic shock. Crit Care 2007, 11(3):R56.
19. Baird CR, Hay AW, McKeown DW, Ray DC. Rapid sequence induction in the emergency department: induction drug and outcome of patients admitted to the intensive care unit. Emerg Med J 2009, 26(8):576-579.
20. Jabre P, Combes X, Lapostolle F, Dhaouadi M, Ricard-Hibon A, Vivien B, Bertrand L, Beltramini A, Gamand P, Albizzati S, et al. Etomidate versus ketamine for rapid sequence intubation in acutely ill patients: a multicentre randomised controlled trial. Lancet 2009, 374(9686):293-300.
21. Annane D. ICU physicians should abandon the use of etomidate!. Intensive Care Med 2005, 31(3):325-326.
22. Jackson WL. Should we use etomidate as an induction agent for endotracheal intubation in patients with septic shock?: a critical appraisal. Chest 2005, 127(3):1031-1038.
23. Kamp R, Kress JP. Etomidate, sepsis, and adrenal function: not as bad as we thought?. Crit Care 2007, 11(3):145.
24. Morel J, Venet C, Donati Y, Charier D, Liotier J, Frere-Meunier D, Guyomarc'h S, Diconne E, Bertrand JC, Souweine B, et al. Adrenal axis function does not appear to be associated with hemodynamic improvement in septic shock patients systematically receiving glucocorticoid therapy. Intensive Care Med 2006, 32(8):1184-1190.
25. Jones D, Hayes M, Webb S, French C, Bellomo R. Relative adrenal insufficiency in etomidate-naive patients with septic shock. Anaesth Intensive Care 2006, 34(5):599-605.
26. Annane D. Etomidate and intensive care physicians. Intensive Care Med 2005, 31:1454.
27. Marik PE, Gayowski T, Starzl TE. The hepatoadrenal syndrome: a common yet unrecognized clinical condition. Crit Care Med 2005, 33(6):1254-1259.
28. Zietz B, Lock G, Plach B, Drobnik W, Grossmann J, Scholmerich J, Straub RH. Dysfunction of the hypothalamic-pituitary-glandular axes and relation to Child-Pugh classification in male patients with alcoholic and virus-related cirrhosis. Eur J Gastroenterol Hepatol 2003, 15(5):495-501.
29. Harry R, Auzinger G, Wendon J. The clinical importance of adrenal insufficiency in acute hepatic dysfunction. Hepatology 2002, 36(2):395-402.
30. Tsai MH, Peng YS, Chen YC, Liu NJ, Ho YP, Fang JT, Lien JM, Yang C, Chen PC, Wu CS. Adrenal insufficiency in patients with cirrhosis, severe sepsis and septic shock. Hepatology 2006, 43(4):673-681.
31. Arabi Y, Ahmed QA, Haddad S, Aljumah A, Al-Shimemeri A. Outcome predictors of cirrhosis patients admitted to the intensive care unit. Eur J Gastroenterol Hepatol 2004, 16(3):333-339.
32. Arabi Y, Haddad S, Goraj R, Al-Shimemeri A, Al-Malik S. Assessment of performance of four mortality prediction systems in a Saudi Arabian intensive care unit. Crit Care 2002, 6(2):166-174.
33. Arabi YM, Aljumah A, Dabbagh O, Tamim HM, Rishu AH, Al-Abdulkareem A, Knawy BA, Hajeer AH, Tamimi W, Cherfan A. Low-dose hydrocortisone in patients with cirrhosis and septic shock: a randomized controlled trial. CMAJ 2010, 182(18):1971-1977.
34. Knaus WA, Draper EA, Wagner DP, Zimmerman JE. APACHE II: a severity of disease classification system. Crit Care Med 1985, 13(10):818-829.
35. Ferreira FL, Bota DP, Bross A, Melot C, Vincent JL. Serial evaluation of the SOFA score to predict outcome in critically ill patients. JAMA 2001, 286(14):1754-1758.
36. Pugh RN, Murray-Lyon IM, Dawson JL, Pietroni MC, Williams R. Transection of the oesophagus for bleeding oesophageal varices. Br J Surg 1973, 60(8):646-649.
37. den Brinker M, Joosten KF, Liem O, de Jong FH, Hop WC, Hazelzet JA, van Dijk M, Hokken-Koelega AC. Adrenal insufficiency in meningococcal sepsis: bioavailable cortisol levels and impact of interleukin-6 levels and intubation with etomidate on adrenal function and mortality. J Clin Endocrinol Metab 2005, 90(9):5110-5117.
38. Annane D, Sebille V, Charpentier C, Bollaert PE, Francois B, Korach JM, Capellier G, Cohen Y, Azoulay E, Troche G, et al. Effect of treatment with low doses of hydrocortisone and fludrocortisone on mortality in patients with septic shock. JAMA 2002, 288(7):862-871.
39. Tarantino G, Citro V, Esposito P, Giaquinto S, de Leone A, Milan G, Tripodi FS, Cirillo M, Lobello R. Blood ammonia levels in liver cirrhosis: a clue for the presence of portosystemic collateral veins. BMC Gastroenterol 2009, 9:21.
40. Ulleras E, Ohlsson A, Oskarsson A. Secretion of cortisol and aldosterone as a vulnerable target for adrenal endocrine disruption-screening of 30 selected chemicals in the human H295R cell model. J Appl Toxicol 2008, 28(8):1045-1053.
41. Hinson JP, Raven PW. Effects of endocrine-disrupting chemicals on adrenal function. Best Pract Res Clin Endocrinol Metab 2006, 20(1):111-120.
42. Jameson P, Desborough JP, Bryant AE, Hall GM. The effect of cortisol suppression on interleukin-6 and white blood cell responses to surgery. Acta Anaesthesiol Scand 1997, 41(2):304-308.
43. Larsen B, Hoff G, Wilhelm W, Buchinger H, Wanner GA, Bauer M. Effect of intravenous anesthetics on spontaneous and endotoxin-stimulated cytokine response in cultured human whole blood. Anesthesiology 1998, 89(5):1218-1227.
44. Sprung CL, Annane D, Keh D, Moreno R, Singer M, Freivogel K, Weiss YG, Benbenishty J, Kalenka A, Forst H, et al. Hydrocortisone therapy for patients with septic shock. N Engl J Med 2008, 358(2):111-124.