Indoxyl Sulfate Induces Endothelial Cell Senescence by Increasing Reactive Oxygen Species Production and p53 Activity

Journal of Renal Nutrition

Volumn 22, Issue 1, 2012, Pages 86-89

  Adelibieke, Yelixiati ^a   Shimizu, Hidehisa ^a   Muteliefu, Gulinuer ^a   Bolati, Dilinaer ^a   Niwa, Toshimitsu ^a  

^a NAGOYA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; DIMETHYLARGININE; DRUG DERIVATIVE; ENZYME INHIBITOR; INDICAN; NITRIC OXIDE SYNTHASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE;

ARTICLE; BLOOD; CELL AGING; CHRONIC KIDNEY FAILURE; DRUG ANTAGONISM; DRUG EFFECT; HUMAN; METABOLISM; PHYSIOLOGY; UMBILICAL VEIN ENDOTHELIAL CELL;

ARGININE; CELL AGING; ENZYME INHIBITORS; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INDICAN; KIDNEY FAILURE, CHRONIC; NITRIC OXIDE SYNTHASE; REACTIVE OXYGEN SPECIES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84855179279     PISSN: 10512276     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.jrn.2011.10.027     Document Type: Article

References (20)

1. Efstratiadis G., Tziomalos K., Mikhailidis D.P., Athyros V.G., Hatzitolios A. Atherogenesis in renal patients: a model of vascular disease?. Curr Vasc Pharmacol 2008, 6:93-107.
2. Schiffrin E.L., Lipman M.L., Mann J.F. Chronic kidney disease: effects on the cardiovascular system. Circulation 2007, 116:85-97.
3. Erusalimsky J.D. Vascular endothelial senescence: from mechanisms to pathophysiology. J Appl Physiol 2009, 106:326-332.
4. Erusalimsky J.D., Kurz D.J. Endothelial cell senescence. Handb Exp Pharmacol 2006, 176:213-248.
5. Niwa T. Uremic toxicity of indoxyl sulfate. Nagoya J Med Sci 2010, 72:1-11.
6. Niwa T., Ise M. Indoxyl sulfate, a circulating uremic toxin, stimulates the progression of glomerular sclerosis. J Lab Clin Med 1994, 124:96-104.
7. Barreto F.C., Barreto D.V., Liabeuf S., et al. Serum indoxyl sulfate is associated with vascular disease and mortality in chronic kidney disease patients. Clin J Am Soc Nephrol 2009, 4:1551-1558.
8. Dou L., Jourde N., Faure V., et al. The uremic solute indoxyl sulfate induces oxidative stress in endothelial cells. J Thromb Haemost 2007, 5:1302-1308.
9. Tumur Z., Niwa T. Indoxyl sulfate inhibits nitric oxide production and cell viability by inducing oxidative stress in vascular endothelial cells. Am J Nephrol 2009, 29:551-557.
10. Dou L., Bertrand E., Cerini C., et al. The uremic solutes p-cresol and indoxyl sulfate inhibit endothelial proliferation and wound repair. Kidney Int 2004, 65:442-451.
11. Faure V., Dou L., Sabatier F., et al. Elevation of circulating endothelial microparticles in patients with chronic renal failure. J Thromb Haemost 2006, 4:566-573.
12. Miyazaki T., Aoyama I., Ise M., Seo H., Niwa T. An oral sorbent reduces overload of indoxyl sulfate and gene expression of TGF-β1 in uremic rat kidneys. Nephrol Dial Transplant 2000, 15:1773-1781.
13. Taki K., Niwa T. Indoxyl sulfate-lowering capacity of oral sorbents affects prognosis of kidney function and oxidative stress in chronic kidney disease. J Ren Nutr 2007, 17:48-52.
14. Namikoshi T., Tomita N., Kitamura K., et al. Oral adsorbent AST-120 ameliorates endothelial dysfunction independent of renal function in rats with subtotal nephrectomy. Hypertens Res 2009, 32:194-200.
15. Shimizu H., Bolati D., Adijiang A., et al. Senescence and dysfunction of proximal tubular cells are associated with activated p53 expression by indoxyl sulfate. Am J Physiol Cell Physiol 2010, 299:C1110-C1117.
16. Scalera F., Borlak J., Beckmann B., et al. Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl L-arginine accelerates endothelial cell senescence. Arterioscler Thromb Vasc Biol 2004, 24:1816-1822.
17. Bode-Böger S.M., Scalera F., Martens-Lobenhoffer J. Asymmetric dimethylarginine (ADMA) accelerates cell senescence. Vasc Med 2005, 10(suppl 1):S65-S71.
18. Vanholder R., De Smet R., Glorieux G., et al. Review on uremic toxins: classification, concentration, and interindividual variability. Kidney Int 2003, 63:1934-1943.
19. Antoniades C., Shirodaria C., Leeson P., et al. Association of plasma asymmetrical dimethylarginine (ADMA) with elevated vascular superoxide production and endothelial nitric oxide synthase uncoupling: implications for endothelial function in human atherosclerosis. Eur Heart J 2009, 30:1142-1150.
20. Leiper J.M., Vallance P., et al. The synthesis and metabolism of asymmetric dimethylarginine (ADMA). Eur J Clin Pharmacol 2006, 62:33-38.