The role of the intestinal barrier function in the pathogenesis of celiac disease

Pediatric and Adolescent Medicine

Volumn 12, Issue , 2008, Pages 89-98

  Fasano, Alessio ^a   Schulzke, Joerg D ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84855169369     PISSN: 10175989     EISSN: 16623886     Source Type: Book Series    
DOI: 10.1159/000128663     Document Type: Review

References (61)

1. Boulpaep EL, Sackin H: Electrical analysis of intraepithelial barriers; in Bronner F, Kleinzeller A, Boulpaep EL (eds): Current Topics in Membranes and Transport. New York, Academic Press, 1980, vol 13, pp 169-197.
2. Gitter AH, Bendfeldt K, Schulzke JD, Fromm M: Leaks in the epithelial barrier caused by spontaneous and TNFinduced single-cell apoptosis. FASEB J 2000;14:1749-1753.
3. Bojarski C, Gitter AH, Bendfeldt K, Mankertz J, Schmitz H, Wagner S, Fromm M, Schulzke JD: Permeability of HT-29/B6 colonic epithelium as a function of apoptosis. J Physiol (Lond) 2001;535:541-552. (Pubitemid 32825689)
4. 2+. II. Impedance measurements. Pflugers Arch 1993;425:535-545. (Pubitemid 24017755)
5. Furuse M, Hirase M, Itoh M, Nagafuchi A, Yonemura S, Tsukita S, Tsukita S: Occludin: a novel integral membrane protein localizing at tight junctions. J Cell Biol 1993;123:1777-1788. (Pubitemid 24012933)
6. Furuse Mikio FK, Hiiragi T, Fujimoto K, Tsukita S: Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J Cell Biol 1998;141:1539-1550. (Pubitemid 28309169)
7. Martin-Padura I, Lostgalio S, Schneemann M, Williams L, Romano M, Fruscella P, Panzeri C, Stoppacciaro A, Ruco L, Vill A, Simmons D, Dejana E: Junctional adhesion molecule, a novel member of the immunoglobulin superfamily that distributes at intercellular junctions and modulates monocyte transmigration. J Biol Chem 1998;142:117-127. (Pubitemid 28341144)
8. Bazzoni G, Martinez-Estrada O, Orsenigo F, Cordenonsi M, Citi S, Dejana E: Interaction of junctional adhesion molecule with the tight junction components, ZO-1, cingulin, and occludin. J Biol Chem 2000;275:20520-20526. (Pubitemid 30457633)
9. Mitic LL, Van Itallie CM: Occludin and claudins: transmembrane proteins of the tight junction; in Cereijido M, Anderson JM (eds): Tight Junctions. Boca Raton, CRC Press, 2001, pp 213-230.
10. Citi S: The cytoplasmic plaque proteins of the tight junction; in Cereijido M, Anderson JM (eds): Tight Junctions. Boca Raton, CRC Press, 2001, pp 231-264.
11. Stevenson BR, Anderson JM, Bullivant S: The epithelial tight junction: structure, function and preliminary biochemical characterization. Mol Cell Biochem 1988;83:129-145.
12. Anderson JM: Cell signalling: MAGUK magic. Curr Biol 1996;6:382-384. (Pubitemid 126656281)
13. Zahraoui A, Joberty G, Arpin M, Fontaine JJ, Hellio R, Tavitian A, Louvard D: A small rab GTPase is distributed in cytoplasmic vesicles in nonpolarized cells but colocalized with the tight junction marker Zo-1 in polarized epithelial cells. J Cell Biol 1994;124:101-115. (Pubitemid 24054613)
14. Denker BM, Saha C, Khawaja S, Nigam SK: Involvement of a heterotrimeric G protein a subunit in tight junction biogenesis. J Biol Chem 1996;271:25750-25753. (Pubitemid 26347401)
15. Dodane V, Kachar B: Identification of isoforms of G proteins and PKC that colocalize with tight junctions. J Membr Biol 1996;149:199-209. (Pubitemid 26076105)
16. Keon BH, Schafer S, Kuhn C, Grund C, Franke WW: Symplekin, a novel type of tight junction plaque protein. J Cell Biol 1996;134:1003-1018. (Pubitemid 26278224)
17. Citi S, Sabannay H, Jakes R, Geiger B, Kendrich-Jones J: Cingulin, a new peripheral component of tight junctions. Nature (Lond) 1988;333:272-275.
18. Gumbiner B: Structure, biochemistry, and assembly of epithelial tight junctions. Am J Physiol 1987;253:C749-C758.
19. Madara JL, Barenberg D, Carlson S: Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity. J Cell Biol 1986;102:2125-2136. (Pubitemid 16052152)
20. Aijaz S, Balda MS, Matter K: Tight junctions: molecular architecture and function. Int Rev Cytol 2006;248:261-298. (Pubitemid 43238173)
21. Hecht F, et al: Expression of the catalytic domain of myosin light chain kinase increases paracellular permeability. Am J Physiol 1996;271:C1678-C1684.
22. Heyman M, Crain-Denoyelle AM, Desjeux JF: Endocytosis and processing of protein by isolated villus and crypt cells of the mouse small intestine. J Pediatr Gastroenterol Nutr 1989;9:238-245. (Pubitemid 19210219)
23. Soderholm JD, Peterson KH, Olaison G, Franzen LE, Westrom B, Magnusson KE, Sjodahl R: Epithelial permeability to proteins in the noninflamed ileum of Crohn's disease? Gastroenterology 1999;117:65-72. (Pubitemid 29297621)
24. Schumann M, Richter JF, Wedell I, Moos V, Zimmermann-Kordmann M, Schneider T, Daum S, Zeitz M, Fromm M, Schulzke JD: Mechanisms of epithelial translocation of the alpha-2-gliadin-33mer in celiac sprue. Gut 2008, E-pub ahead of print.
25. Soderholm JD, Streutker C, Yang PC, Paterson C, Singh PK, McKay DM, Sherman PM, Croitoru K, Perdue MH: Increased epithelial uptake of protein antigens in the ileum of Crohn's disease mediated by tumour necrosis factor alpha. Gut 2004;53:1817-1824. (Pubitemid 39556903)
26. Terpend K, Boisgerault F, Blaton MA, Desjeux JF, Heyman M: Protein transport and processing by human HT29-19A intestinal cells: effect of IFN-γ. Gut 1998;42:538-545. (Pubitemid 28186572)
27. Bruewer M, Samarin S, Nusrat A: Inflammatory bowel disease and the apical junctional complex. Ann NY Acad Sci 2006;1072:242-252. (Pubitemid 44448457)
28. Clayburgh DR, Shen L, Turner JR: A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest 2004;84:282-291. (Pubitemid 41656483)
29. Laukoetter MG, Bruewer M, Nusrat A: Regulation of the intestinal epithelial barrier by the apical junctional complex. Curr Opin Gastroenterol 2006;22:85-89. (Pubitemid 44090070)
30. Hollander D: Crohn's disease, TNF-alpha, and the leaky gut: the chicken or the egg? Am J Gastroenterol 2002;97:1867-1868.
31. Chiba H, Kojima T, Osanai M, Sawada N: The significance of IFN-γ-triggered internalization of tight-junction proteins in inflammatory bowel disease. Sci STKE 2006;2006:pe1.
32. Schulzke JD, Schulzke I, Fromm M, Riecken EO: Epithelial barrier and ion transport in coeliac sprue: electrical measurements on intestinal aspiration biopsy specimens. Gut 1995;37:777-782.
33. Schmitz H, Fromm M, Bentzel CJ, et al: Tumor necrosis factor-alpha (TNFalpha) regulates the epithelial barrier in the human intestinal cell line HT-29/B6. J Cell Sci 1999;112:137-146. (Pubitemid 29043841)
34. Bruewer M, Luegering A, Kucharzik T, et al: Proinflammatory cytokines disrupt epithelial barrier function by apoptosis-independent mechanisms. J Immunol 2003;171:6164-6172. (Pubitemid 37467239)
35. Ivanov AI, Nusrat A, Parkos CA: Endocytosis of epithelial apical junctional proteins by a clathrin-mediated pathway into a unique storage compartment. Mol Biol Cell 2004;15:176-188. (Pubitemid 38044954)
36. Bruewer M, Utech M, Ivanov AI, et al: Interferon-γ induces internalization of epithelial tight junction proteins via a macropinocytosis- like process. Faseb J 2005;19:923-933. (Pubitemid 40827713)
37. Utech M, Ivanov AI, Samarin SN, et al: Mechanism of IFN-gamma-induced endocytosis of tight junction proteins: myosin II-dependent vacuolarization of the apical plasma membrane. Mol Biol Cell 2005;16:5040-5052. (Pubitemid 41416480)
38. Segain JP, Raingeard de la Bletiere D, Sauzeau V, et al: Rho kinase blockade prevents inflammation via nuclear factor kappa B inhibition: evidence in Crohn's disease and experimental colitis. Gastroenterology 2003;124:1180-1187. (Pubitemid 36531793)
39. Ma TY, Boivin MA, Ye D, et al: Mechanism of TNF-α modulation of Caco-2 intestinal epithelial tight junction barrier: role of myosin light-chain kinase protein expression. Am J Physiol Gastrointest Liver Physiol 2005;288:G422-G430. (Pubitemid 40261739)
40. Ye D, Ma I, Ma TY: Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol 2006;290:G496-G504.
41. Wang F, Schwarz BT, Graham WV, Wang Y, Su L, Clayburgh DR, Abraham C, Turner JR: IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 2006;131:1153-1163. (Pubitemid 44515106)
42. Mankertz J, Tavalali S, Schmitz H, et al: Expression from the human occludin promoter is affected by tumor necrosis factor alpha and interferon gamma. J Cell Sci 2000;113:2085-2090. (Pubitemid 30386512)
43. Willemsen LE, Hoetjes JP, van Deventer SJ, van Tol EA: Abrogation of IFN-gamma mediated epithelial barrier disruption by serine protease inhibition. Clin Exp Immunol 2005;142:275-284. (Pubitemid 41565243)
44. Heller F, Florian P, Bojarski C, et al: Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology 2005;129:550-564. (Pubitemid 41096643)
45. Perl A: Pathogenesis and spectrum of autoimmunity. Methods Mol Med 2004;102:1-8.
46. Christen U, von Herrath MG: Induction, acceleration or prevention of autoimmunity by molecular mimicry. Mol Immunol 2004;40:1113-1120. (Pubitemid 38221193)
47. Miller A, Lider O, Weiner HL: Antigendriven bystander suppression after oral administration of antigens. J Exp Med 1991;174:791-798.
48. Rook GA, Brunet LR: Microbes, immunoregulation, and the gut. Gut 2005;54:317-320. (Pubitemid 40299080)
49. Bjarnason I, et al: The G. U. T. of gut. Scand J Gastroenterol 2004;39:807-815.
50. Wendling D: Role of the intestine in the physiopathology of inflammatory rheumatism. Rev Rhum Mal Osteoartic 1992;59:389-392.
51. Watts T, et al: Role of the intestinal tight junction modulator zonulin in the pathogenesis of type I diabetes in BB diabetic-prone rats. Proc Natl Acad Sci USA 2005;102:2916-2921. (Pubitemid 40299891)
52. Schulzke JD, Bentzel CJ, Schulzke I, Riecken EO, Fromm M: Epithelial tight junction structure in the jejunum of children with acute and treated celiac sprue. Pediatr Res 1998;43:435-441. (Pubitemid 28157949)
53. Madara JL, Trier JS: Structural abnormalities of jejunal epithelial cell membranes in celiac sprue. Lab Invest 1980;43:254-261. (Pubitemid 10061705)
54. Schulzke JD, Schulzke I, Fromm M, Riecken EO: Epithelial barrier and ion transport in coeliac sprue: electrical measurements on intestinal aspiration biopsy specimens. Gut 1995;37:777-782.
55. Schulzke JD, Fromm M, Menge H, Riecken EO: Impaired intestinal Naand Cl-transport in the blind loop syndrome of the rat. Gastroenterology 1987;92:693-698. (Pubitemid 17023732)
56. O'Mahony S, Vestey JP, Ferguson A: Similarities in intestinal humoral immunity in dermatitis herpetiformis without enteropathy and in coeliac disease. Lancet 1990;335:1487-1490. (Pubitemid 20224903)
57. Zimmer KP, Poremba C, Weber P, Ciclitira PJ, Harms E: Translocation of gliadin into HLA-DR antigen containing lysosomes in coeliac disease enterocytes. Gut 1995;36:703-709.
58. Zimmer KP, Naim H, Weber P, Ellis HJ, Ciclitira PJ: Targeting of gliadin peptides, CD8, alpha/beta-TCR, and gamma/delta-TCR to Golgi complexes and vacuoles within celiac disease enterocytes. FASEB J 1998;12:1349-1357. (Pubitemid 28475576)
59. Montalto M, et al: Lactobacillus acidophilus protects tight junctions from aspirin damage in HT-29 cells. Digestion 2004;69:225-228. (Pubitemid 39140468)
60. Rosenfeldt V, et al: Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J Pediatr 2004;145:612-616. (Pubitemid 39440938)
61. Seehofer D, et al: Probiotics partly reverse increased bacterial translocation after simultaneous liver resection and colonic anastomosis in rats. J Surg Res 2004;117:262-271. (Pubitemid 38393652)