The nuclear factor-κB inhibitor pyrrolidine dithiocarbamate reduces polyinosinic-polycytidilic acid-induced immune response in pregnant rats and the behavioral defects of their adult offspring

Behavioral and Brain Functions

Volumn 7, Issue , 2011, Pages

  Song, Xueqin ^a,b   Li, Wenqiang ^b   Yang, Yongfeng ^b   Zhao, Jingping ^c   Jiang, Chengdi ^b   Li, Wei ^b   Lv, Luxian ^b  

^a THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIVERSITY   (China)

^b XINXIANG MEDICAL UNIVERSITY   (China)

^c CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Active avoidance; Cytokine; Nuclear factor kappa b inhibitor; Passive avoidance; Prepulse inhibition

Indexed keywords

INTERLEUKIN 10; POLYINOSINIC POLYCYTIDYLIC ACID; PYRROLIDINE DITHIOCARBAMATE; TUMOR NECROSIS FACTOR ALPHA; ANTIOXIDANT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PYRROLIDINE DERIVATIVE; PYRROLIDINE DITHIOCARBAMIC ACID; THIOCARBAMIC ACID DERIVATIVE;

ANIMAL EXPERIMENT; ARTICLE; BEHAVIOR DISORDER; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FIRST TRIMESTER PREGNANCY; IMMUNE DEFICIENCY; IMMUNE RESPONSE; MALE; MENTAL DISEASE; NONHUMAN; PASSIVE AVOIDANCE; PREPULSE INHIBITION; PRIORITY JOURNAL; PROGENY; PROTEIN BLOOD LEVEL; RAT; ANIMAL; AVOIDANCE BEHAVIOR; BLOOD; CHEMICALLY INDUCED DISORDER; DRUG ANTAGONISM; DRUG EFFECT; IMMUNOLOGY; NEUROLOGIC DISEASE; PHYSIOLOGY; PREGNANCY; PRENATAL EXPOSURE; RANDOMIZATION; SPRAGUE DAWLEY RAT;

ANIMALS; ANTIOXIDANTS; AVOIDANCE LEARNING; FEMALE; INTERLEUKIN-10; MALE; NERVOUS SYSTEM DISEASES; NF-KAPPA B; POLY I-C; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; PYRROLIDINES; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY; THIOCARBAMATES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84855167703     PISSN: None     EISSN: 17449081     Source Type: Journal    
DOI: 10.1186/1744-9081-7-50     Document Type: Article

References (45)

1. Brown AS, Schaefer CA, Wyatt RJ, Goetz R, Begg MD, Gorman JM, Susser ES. Maternal exposure to respiratory infections and adult schizophrenia spectrum disorders: a prospective birth cohort study. Schizophr Bull 2000, 26(2):287-95.
2. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan M, Babulas VP, Susser ES. Serologic evidence of prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 2004, 61(8):774-80. 10.1001/archpsyc.61.8.774, 15289276.
3. Hultman CM, Sparén P, Takei N, Murray RM, Cnattingius S. Prenatal and perinatal risk factors for schizophrenia, affective psychosis, and reactive psychosis of early onset: case-control study. BMJ 1999, 318(7181):421-6. 10.1136/bmj.318.7181.421, 27730, 9974454.
4. Cannon M, Clarke MC. Risk for schizophrenia -- broadening the concepts, pushing back the boundaries. Schizophr Res 2005, 79(1):5-13. 10.1016/j.schres.2005.05.027, 16005613.
5. McDonald C, Murray RM. Early and late environmental risk factors for schizophrenia. Brain Res Brain Res Rev 2000, 31(2-3):130-7.
6. Mino Y, Oshima I, Tsuda T, Okagami K. No relationship between schizophrenic birth and influenza epidemics in Japan. J Psychiatr Res 2000, 34(2):133-8. 10.1016/S0022-3956(00)00003-0, 10758255.
7. Morgan V, Castle D, Page A, Fazio S, Gurrin L, Burton P, Montgomery P, Jablensky A. Influenza epidemics and incidence of schizophrenia, affective disorders and mental retardation in Western Australia: no evidence of a major effect. Schizophr Res 1997, 26(1):25-39. 10.1016/S0920-9964(97)00033-9, 9376335.
8. Patterson PH. Maternal infection: window on neuroimmune interactions in fetal brain development and mental illness. Curr Opin Neurobiol 2002, 12(1):115-8. 10.1016/S0959-4388(02)00299-4, 11861174.
9. Smith SE, Li J, Garbett K, Mirnics K, Patterson PH. Maternal Immune Activation Alters Fetal Brain Development through Interleukin-6. J Neurosci 2007, 27(40):10695-702. 10.1523/JNEUROSCI.2178-07.2007, 2387067, 17913903.
10. Gilmore JH, Fredrik Jarskog L, Vadlamudi S, Lauder JM. Prenatal infection and risk for schizophrenia: IL-1beta, IL-6, and TNFalpha inhibit cortical neuron dendrite development. Neuropsychopharmacology 2004, 29(7):1221-9. 10.1038/sj.npp.1300446, 15085088.
11. Brown AS, Hooton J, Schaefer CA, Zhang H, Petkova E, Babulas V, Perrin M, Gorman JM, Susser ES. Elevated maternal interleukin-8 levels and risk of schizophrenia in adult offspring. Am J Psychiatry 2004, 161(5):889-95. 10.1176/appi.ajp.161.5.889, 15121655.
12. Buka SL, Tsuang MT, Torrey EF, Klebanoff MA, Wagner RL, Yolken RH. Maternal cytokine levels during pregnancy and adult psychosis. Brain Behav Immun 2001, 15(4):411-20. 10.1006/brbi.2001.0644, 11782107.
13. Meyer U, Feldon J, Schedlowski M, Yee BK. Towards an immuno-precipitated neurodevelopmental animal model of schizophrenia. Neurosci Biobehav Rev 2005, 29(6):913-47. 10.1016/j.neubiorev.2004.10.012, 15964075.
14. Meyer U, Feldon J, Schedlowski M, Yee BK. Immunological stress at the maternal-foetal interface: A link between neurodevelopment and adult psychopathology. Brain Behav Immun 2006, 20(4):378-88. 10.1016/j.bbi.2005.11.003, 16378711.
15. Meyer U, Nyffeler M, Engler A, Urwyler A, Schedlowski M, Knuesel I, Yee BK, Feldon J. The time of prenatal immune challenge determines the specificity of inflammation-mediated brain and behavioral pathology. J Neurosci 2006, 26(18):4752-62. 10.1523/JNEUROSCI.0099-06.2006, 16672647.
16. Meyer U, Schwendener S, Feldon J, Yee BK. Prenatal and postnatal maternal contributions in the infection model of schizophrenia. Exp Brain Res 2006, 173(2):243-57. 10.1007/s00221-006-0419-5, 16552558.
17. Ozawa K, Hashimoto K, Kishimoto T, Shimizu E, Ishikura H, Iyo M. Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia. Biol Psychiatry 2006, 59(6):546-54. 10.1016/j.biopsych.2005.07.031, 16256957.
18. Zuckerman L, Weiner I. Maternal immune activation leads to behavioral and pharmacological changes in the adult offspring. J Psychiatr Res 2005, 39(3):311-23. 10.1016/j.jpsychires.2004.08.008, 15725430.
19. Gilmore JH, Jarskog LF. Exposure to infection and brain development: cytokines in the pathogenesis of schizophrenia. Schizophr Res 1997, 24(3):365-7. 10.1016/S0920-9964(96)00123-5, 9134598.
20. Alexopoulou L, Holt AC, Medzhitov R, Flavell RA. Recognition of double-stranded RNA and activation of NF-[kappa]B by Toll-like receptor 3. Nature 2001, 413(6857):732-8. 10.1038/35099560, 11607032.
21. Fortier ME, Kent S, Ashdown H, Poole S, Boksa P, Luheshi GN. The viral mimic, polyinosinic:polycytidylic acid, induces fever in rats via an interleukin-1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol 2004, 287(4):R759-66. 10.1152/ajpregu.00293.2004, 15205185.
22. Traynor TR, Majde JA, Bohnet SG, Krueger JM. Intratracheal double-stranded RNA plus interferon-gamma: a model for analysis of the acute phase response to respiratory viral infections. Life Sci 2004, 74(20):2563-76. 10.1016/j.lfs.2003.10.010, 15010266.
23. Zuckerman L, Rehavi M, Nachman R, Weiner I. Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia. Neuropsychopharmacology 2003, 28(10):1778-89. 10.1038/sj.npp.1300248, 12865897.
24. Zuckerman L, Weiner I. Post-pubertal emergence of disrupted latent inhibition following prenatal immune activation. Psychopharmacology (Berl) 2003, 169(3-4):308-13.
25. Shi L, Fatemi SH, Sidwell RW, Patterson PH. Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring. J Neurosci 2003, 23(1):297-302.
26. Baeuerle PA. The inducible transcription activator NF-kappa B: regulation by distinct protein subunits. Biochim Biophys Acta 1991, 1072(1):63-80.
27. Song XQ, Lv LX, Li WQ, Hao YH, Zhao JP. The Interaction of Nuclear Factor-Kappa B and Cytokines Is Associated with Schizophrenia. Biol Psychiatry 2009, 65(6):481-8. 10.1016/j.biopsych.2008.10.018, 19058794.
28. O'Hara AM, O'Regan P, Fanning A, O'Mahony C, Macsharry J, Lyons A, Bienenstock J, O'Mahony L, Shanahan F. Functional modulation of human intestinal epithelial cell responses by Bifidobacterium infantis and Lactobacillus salivarius. Immunology 2006, 118(2):202-15. 10.1111/j.1365-2567.2006.02358.x, 1782284, 16771855.
29. Renard P, Ernest I, Houbion A, Art M, Le Calvez H, Raes M, Remacle J. Development of a sensitive multi-well colorimetric assay for active NFκB. Nucleic Acids Res 2001, 29(4):E21. 10.1093/nar/29.4.e21, 29628, 11160941.
30. Trigo JM, Cabrero-Castel A, Berrendero F, Maldonado R, Robledo P. MDMA modifies active avoidance learning and recall in mice. Psychopharmacology (Berl) 2008, 197(3):391-400.
31. Meyer U, Nyffeler M, Schwendener S, Knuesel I, Yee BK, Feldon J. Relative prenatal and postnatal maternal contributions to schizophrenia-related neurochemical dysfunction after in utero immune challenge. Neuropsychopharmacology 2008, 33(2):441-56. 10.1038/sj.npp.1301413, 17443130.
32. Meyer U, Nyffeler M, Yee BK, Knuesel I, Feldon J. Adult brain and behavioral pathological markers of prenatal immune challenge during early/middle and late fetal development in mice. Brain Behav Immun 2008, 22(4):469-86. 10.1016/j.bbi.2007.09.012, 18023140.
33. Loukili N, Rosenblatt-Velin N, Rolli J, Levrand S, Feihl F, Waeber B, Pacher P, Liaudet L. Oxidants positively or negatively regulate nuclear factor kappaB in a context-dependent manner. J Biol Chem 2010, 285(21):15746-52. 10.1074/jbc.M110.103259, 2871441, 20299457.
34. Seymour EM, Bennink MR, Watts SW, Bolling SF. Whole grape intake impacts cardiac peroxisome proliferator-activated receptor and nuclear factor kappaB activity and cytokine expression in rats with diastolic dysfunction. Hypertension 2010, 55(5):1179-85. 10.1161/HYPERTENSIONAHA.109.149393, 2929369, 20231522.
35. Wang S, Quang Le T, Chida J, Cisse Y, Yano M, Kido H. Mechanisms of matrix metalloproteinase-9 upregulation and tissue destruction in various organs in influenza A virus infection. J Med Invest 2010, 57(1-2):26-34.
36. Gayle DA, Beloosesky R, Desai M, Amidi F, Nuñez SE, Ross MG. Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain. Am J Physiol Regul Integr Comp Physiol 2004, 86(6):R1024-9.
37. Baruch I, Hemsley DR, Gray JA. Differential performance of acute and chronic schizophrenics in a latent inhibition task. J. Nerv Ment Dis 1988, 176(10):598-606. 10.1097/00005053-198810000-00004, 2903219.
38. Gray NS, Snowden RJ. The relevance of irrelevance to schizophrenia. Neurosci Biobehav Rev 2005, 29(6):989-99. 10.1016/j.neubiorev.2005.01.006, 15967503.
39. Lubow RE. Construct validity of the animal latent inhibition model of selective attention deficits in schizophrenia. Schizophr Bull 2005, 31(1):139-53. 10.1093/schbul/sbi005, 15888432.
40. Yogev H, Sirota P, Gutman Y, Hadar U. Latent inhibition and overswitching in schizophrenia. Schizophr Bull 2004, 30(4):713-26.
41. Salgado JV, Hetem LA, Vidal M, Graeff FG, Danion JM, Sandner G. Reduction of latent inhibition by D-amphetamine in a conditioned suppression paradigm in humans. Behav Brain Res 2000, 117(1-2):61-7. 10.1016/S0166-4328(00)00279-5, 11099758.
42. Lubow RE, De la Casa G. Latent inhibition as a function of schizotypality and gender: implications for schizophrenia. Biol Psychol 2002, 59(1):69-86. 10.1016/S0301-0511(01)00124-7, 11790444.
43. Saviouk V, Chow EW, Bassett AS, Brzustowicz LM. Tumor necrosis factor promoter haplotype associated with schizophrenia reveals a linked locus on 1q44. Mol Psychiatry 2005, 10(4):375-83. 10.1038/sj.mp.4001582, 3133762, 15340354.
44. Meyer U, Feldon J, Yee BK. A review of the fetal brain cytokine imbalance hypothesis of schizophrenia. Schizophr Bull 2009, 35(5):959-72. 10.1093/schbul/sbn022, 2728807, 18408229.
45. J Haddad JJ, Saadé NE, Safieh-Garabedian B. Cytokines and neuro-immune-endocrine interactions: a role for the hypothalamic-pituitary-adrenal revolving axis. J Neuroimmunol 2002, 133(1-2):1-19. 10.1016/S0165-5728(02)00357-0, 12446003.