Novel poly(ADP-ribose) polymerase-1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 222-224

  Dunn, Derek ^a   Husten, Jean ^a   Ator, Mark A ^a   Chatterjee, Sankar ^a  

^a CEPHALON INC   (United States)

Author keywords

Oncology; PARP 1; Pyrrolocarbazole

Indexed keywords

AMINE; CARBAZOLE DERIVATIVE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1 INHIBITOR; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE INHIBITOR; PROLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE PERMEABILITY; DRUG ACTIVITY; DRUG SYNTHESIS; ENZYME ACTIVITY; ENZYME INHIBITION;

ANIMALS; ANTINEOPLASTIC AGENTS; CARBAZOLES; CHEMISTRY, PHARMACEUTICAL; DNA DAMAGE; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MODELS, CHEMICAL; NAD; NEOPLASMS; PC12 CELLS; POLY(ADP-RIBOSE) POLYMERASES; RATS;

EID: 84655176609     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.032     Document Type: Article

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