Synthesis and evaluation of 4-alkoxy-[1′-cyclobutyl-spiro(3,4- dihydrobenzopyran-2,4′-piperidine)] analogues as histamine-3 receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 186-189

  Becknell, Nadine C ^a   Dandu, Reddeppa Reddy ^a   Lyons, Jacquelyn A ^a   Aimone, Lisa D ^a   Raddatz, Rita ^a   Hudkins, Robert L ^a  

^a CEPHALON INC   (United States)

Author keywords

CEP 26401; H 3R antagonists; Histamine H 3; Spiro dihydrobenzopyran; Sulfone

Indexed keywords

ANTIHISTAMINIC AGENT; CYTOCHROME P450; HISTAMINE H3 RECEPTOR; IRDABISANT; PIPERIDINE DERIVATIVE; POTASSIUM CHANNEL HERG; SULFONE;

AREA UNDER THE CURVE; ARTICLE; DRUG BIOAVAILABILITY; DRUG BRAIN LEVEL; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

ANIMALS; CHEMISTRY, PHARMACEUTICAL; DRUG DESIGN; DRUG INTERACTIONS; ETHER-A-GO-GO POTASSIUM CHANNELS; HISTAMINE ANTAGONISTS; HUMANS; INHIBITORY CONCENTRATION 50; KINETICS; LIVER; MICE; MODELS, CHEMICAL; PIPERIDINES; RATS; RECEPTORS, HISTAMINE H3; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84655176598     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.038     Document Type: Article

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