Complete response after sorafenib therapy for hepatocellular carcinoma in an HIV-HBV co infected patient: Possible synergy with HAART ? A case report

Medical Oncology

Volumn 28, Issue SUPPL. 1, 2011, Pages

  Chelis, Leonidas ^a   Ntinos, Napoleon ^a   Souftas, Vasilios ^a   Deftereos, Savas ^a   Xenidis, Nikolaos ^a   Chamalidou, Elen ^a   Maltezos, Eustratios ^a   Kakolyris, Stylianos ^a  

^a DEMOCRITUS UNIVERSITY OF THRACE   (Greece)

Author keywords

Co infection; Complete response; HBV; Hepatocellular carcinoma; HIV; Sorafenib

Indexed keywords

EMTRICITABINE PLUS TENOFOVIR DISOPROXIL; LOPINAVIR PLUS RITONAVIR; SORAFENIB;

AGED; ARTICLE; CANCER GROWTH; CASE REPORT; CHEMOEMBOLIZATION; COMPUTER ASSISTED TOMOGRAPHY; DIARRHEA; DRUG DOSE REDUCTION; HAND FOOT SKIN REACTION; HEPATITIS B; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; HYPERTENSION; LIVER CELL CARCINOMA; MALE; MIXED INFECTION; PRIORITY JOURNAL; SKIN MANIFESTATION; TREATMENT RESPONSE;

EID: 84655170231     PISSN: 13570560     EISSN: 1559131X     Source Type: Journal    
DOI: 10.1007/s12032-010-9669-y     Document Type: Article

References (20)

1. AS Lok 2004 Prevention of hepatitis B virus-related hepatocellular carcinoma Gastroenterology 127 S303 S309
2. DC [tmp] MacDonald M Nelson M Bower T Powles 2008 Hepatocellular carcinoma, human immunodeficiency virus and viral hepatitis in the HAART era World J Gastroenterol 14 11 1657 1663 (Pubitemid 351493371)
3. D Iser S Lewin 2009 The pathogenesis of liver disease in the setting of HIV-hepatitis B virus coinfection Antivir Ther 14 2 155 164
4. K Bhaskaran O Hamouda M Sannes 2008 Changes in the risk of death after HIV seroconvertion compared with mortality in the general population JAMA 300 51 59 (Pubitemid 351920404)
5. R Weber CA Sabin N Friis-Moller 2006 Liver-relared deaths in persons infected with the human immunodeficiency virus: the D:A:D study Arch Intern Med 166 1632 1641 (Pubitemid 44232373)
6. GM Clifford M Rickenbach J Polesel 2008 Influence of HIV-related immunodeficiency on the risk of hepatocellular carcinoma AIDS 22 2135 2141
7. D Salmon-Ceron E Rosenthal C Lewden 2009 Emerging role of hepatocellular carcinoma among liver-related causes of death in HIV-infected patients The French national Mortalitè 2005 study J Hepatology 50 739 745
8. J Bruix M Sherman 2005 Management of hepatocellular carcinoma Hepatology 42 1208 1236 (Pubitemid 43112690)
9. JM Llovet S Ricci V Mazzaferro 2008 Sorafenib in advanced hepatocellular carcinoma N Engl J Med 359 378 390
10. AL Cheng YK Kang Z Chen 2009 Efficacy and safety of sorafenib in patients in the Asia-Pacific region with advanced hepatocellular carcinoma: A phase III randomized, double-blind, placebo-controlled trial Lancet Oncol 10 25 34
11. G Perboni P Costa GC Fibbia 2010 Sorafenib therapy for Hepatocellular carcinoma in an HIV-HCV Coinfectd Patient: A Case report The Oncologist 15 2 142 145 Epub 2010 Feb 8
12. BJ So T Bekaii-Saab MA Bloomston T Patel 2008 Complete clinical response of metastatic hepatocellular carcinoma to sorafenib in a patient with hemochromatosis: A case report Journal of Hematology & Oncology 1 18
13. WA Chow C Jiang M Guan 2009 Anti-HIV drugs for cancer therapeutics: back to the future? Lancet Oncol 10 61 71
14. S Kumar CS Bryant S Chamala 2009 Ritonavir blocks AKT signalling, activates apoptosis and inhibits migration and invasion in ovarian cancer cells Mol Cancer 8 26
15. A Srirangam R Mitra M Wang 2006 Effects of HIV protease inhibitor ritonavir on Akt-regulated cell proliferation in breast cancer Clin Cancer Res 12 1883 1896
16. A Villanueva DY Chiang P Newell 2008 Pivotal role of mTOR signalling in hepatocellular carcinoma Gastroenterology 135 6 1972 1983
17. RS Finn 2010 Development of molecularly targeted therapies in hepatocellular carcinoma: where do we go now? Clin Cancer Res 16 2 390 397 Epub 2010 Jan 12
18. A Brüning M Rahmeh A Gingelmaier K Friese 2010 The mitochondria-independent cytotoxic effect of nelfinavir on leukemia cells can be enhanced by sorafenib-mediated mcl-1 downregulation and mitochondrial membrane destabilization Mol Cancer 9 19
19. Brüning A, Burger P, Vogel M, Gingelmaier A, Friese K, Burges A. Nelfinavir induces mitochondria protection by ERK1/2-mediated mcl-1 stabilization that can be overcome by sorafenib. Invest New Drugs;2009.
20. V Soriano E Vispo P Labarga 2010 Viral hepatitis and HIV co-infection Antiviral Res 85 1 303 315