Cocrystallization and amorphization induced by drug-excipient interaction improves the physical properties of acyclovir

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 160-169

  Masuda, Takaaki ^a,b   Yoshihashi, Yasuo ^b   Yonemochi, Etsuo ^b   Fujii, Kotaro ^c   Uekusa, Hidehiro ^c   Terada, Katsuhide ^b  

^a POLA PHARMA INC   (Japan)

^b TOHO UNIVERSITY   (Japan)

^c TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

Acyclovir; Amorphous; Cocrystal; Dissolution rate; Drug excipient interactions; Transdermal absorption

Indexed keywords

ACICLOVIR; EXCIPIENT;

ARTICLE; CRYSTALLIZATION; DRUG FORMULATION; DRUG PENETRATION; DRUG POTENCY; DRUG SOLUBILITY; EXCIPIENT COMPATIBILITY; IN VITRO STUDY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; SKIN PERMEABILITY;

ACYCLOVIR; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIVIRAL AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CITRIC ACID; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DRUG COMPOUNDING; EXCIPIENTS; HYDROGEN-ION CONCENTRATION; KINETICS; MALE; MICE; MICE, HAIRLESS; MODELS, MOLECULAR; OINTMENTS; POLYETHYLENE GLYCOLS; POWDER DIFFRACTION; SKIN; SKIN ABSORPTION; SOLUBILITY; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SYNCHROTRONS; TARTRATES; TECHNOLOGY, PHARMACEUTICAL; THERMOGRAVIMETRY;

EID: 84655169574     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.046     Document Type: Article

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