Enhancement of skin permeation of ketotifen by supersaturation generated by amorphous form of the drug

Journal of Controlled Release

Volumn 108, Issue 2-3, 2005, Pages 306-318

  Inoue, Kazuhiro ^a   Ogawa, Kengo ^a   Okada, Jun'ichi ^a   Sugibayashi, Kenji ^b  

^a DAIICHI SANKYO CO   (Japan)

^b JOSAI UNIVERSITY   (Japan)

Author keywords

Amorphous; Drug release; Ketotifen; Penetration enhancement; Pressure sensitive adhesive; Skin permeation; Solvent casting method; Supersaturation

Indexed keywords

CRYSTALLINE MATERIALS; DRUG DOSAGE; MECHANICAL PERMEABILITY; ORGANIC SOLVENTS; SILICONES; SUPERSATURATION;

AMORPHOUS; DRUG RELEASE; KETOTIFEN; PENETRATION ENHANCEMENTS; PRESSURE SENSITIVE ADHESIVES; SKIN PERMEATION; SOLVENT CASTING METHODS;

SKIN;

ACETIC ACID ETHYL ESTER; ACETONE; DICHLOROMETHANE; HEXANE; KETOTIFEN; SILICONE; SOLVENT; TETRAHYDROFURAN; TOLUENE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CRYSTALLIZATION; DILUTION; DRUG DOSAGE FORM; DRUG PENETRATION; DRUG RELEASE; DRUG SOLUBILITY; EXCISION; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL; SKIN PERMEABILITY; STEADY STATE;

ADHESIVES; ADMINISTRATION, TOPICAL; ALGORITHMS; ANIMALS; ANTI-ALLERGIC AGENTS; CALORIMETRY, DIFFERENTIAL SCANNING; CHEMISTRY, PHYSICAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIFFUSION; KETOTIFEN; MICE; MICE, INBRED HRS; SILICONES; SKIN ABSORPTION; SOLUBILITY; SOLUTIONS; SPECTROPHOTOMETRY, ULTRAVIOLET; X-RAY DIFFRACTION;

EID: 27744483727     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2005.08.008     Document Type: Article

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