Acinar cell carcinoma of the pancreas and related neoplasms: A review

Diagnostic Histopathology

Volumn 18, Issue 1, 2012, Pages 8-16

  Basturk, Olca ^a   Klimstra, David S ^a  

^a MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Acinar cell carcinoma; Chymotrypsin; Neuroendocrine tumour; Pancreas; Trypsin

Indexed keywords

ALPHA 1 ANTICHYMOTRYPSIN; ALPHA 1 ANTITRYPSIN; ALPHA FETOPROTEIN; AMYLASE; ANTINEOPLASTIC AGENT; APC PROTEIN; BETA CATENIN; CD56 ANTIGEN; CHROMOGRANIN; CHYMOTRYPSIN; CLAUDIN 5; CLAUDIN 7; COMMON ACUTE LYMPHOBLASTIC LEUKEMIA ANTIGEN; CYCLIN DEPENDENT KINASE INHIBITOR 2A; CYTOKERATIN AE1; CYTOKERATIN AE3; K RAS PROTEIN; KERATIN; PHOSPHOLIPASE A2; PROGESTERONE RECEPTOR; PROTEIN BCL 10; PROTEIN P53; SMAD4 PROTEIN; SOMATOSTATIN; SYNAPTOPHYSIN; TRIACYLGLYCEROL LIPASE; TRYPSIN; UVOMORULIN; VIMENTIN; ZYMOGEN GRANULE;

ABDOMINAL MASS; ABDOMINAL PAIN; ACINAR CELL; ACINAR CELL CARCINOMA; ANEMIA; ARTHRALGIA; ARTICLE; BLOATING; CANCER CELL; CANCER CHEMOTHERAPY; CANCER INVASION; CANCER MORPHOLOGY; CANCER STAGING; CANCER SURGERY; CANCER SURVIVAL; CELL NUCLEUS; CHROMATIN; CHROMOSOME 11P; CHROMOSOME LOSS; CYSTADENOCARCINOMA; DIARRHEA; DIFFERENTIAL DIAGNOSIS; ELECTRON MICROSCOPY; FAT NECROSIS; GENE MUTATION; HISTOCHEMISTRY; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTRADUCTAL TUBULOPAPILLARY NEOPLASM; LIVER METASTASIS; MITOSIS; MIXED TUMOR; MOLECULAR GENETICS; NAUSEA AND VOMITING; NEUROENDOCRINE TUMOR; PANCREAS CARCINOMA; PANCREAS TUMOR; PANCREATOBLASTOMA; PROGNOSIS; SIGNAL TRANSDUCTION; SURVIVAL RATE; WEIGHT REDUCTION;

EID: 84655169150     PISSN: 17562317     EISSN: 18767621     Source Type: Journal    
DOI: 10.1016/j.mpdhp.2011.10.011     Document Type: Article

References (35)

1. Klimstra D.S., Heffess C.S., Oertel J.E., Rosai J. Acinar cell carcinoma of the pancreas. A clinicopathologic study of 28 cases. Am J Surg Pathol 1992, 16:815-837.
2. Klimstra D.S., Hruban R.H., Klöppel G., Morohoshi T., Ohike N. Acinar cell neoplasms of the pancreas. World Health Organization classification of tumours of the digestive system 2010, WHO Press, Geneva. F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise (Eds.).
3. Holen K.D., Klimstra D.S., Hummer A., et al. Clinical characteristics and outcomes from an institutional series of acinar cell carcinoma of the pancreas and related tumors. JClin Oncol 2002, 20:4673-4678.
4. Cingolani N., Shaco-Levy R., Farruggio A., Klimstra D.S., Rosai J. Alpha-fetoprotein production by pancreatic tumors exhibiting acinar cell differentiation: study of five cases, one arising in a mediastinal teratoma. Hum Pathol 2000, 31:938-944.
5. Hruban R.H., Pitman M.B., Klimstra D.S. Tumors of the pancreas. AFIP atlas of tumor pathology 2007, ARP Press, Washington, DC. 4th edn. S.G. Silverberg (Ed.).
6. Basturk O., Zamboni G., Klimstra D.S., et al. Intraductal and papillary variants of acinar cell carcinomas: a new addition to the challenging differential diagnosis of intraductal neoplasms. Am J Surg Pathol 2007, 31:363-370.
7. Ban D., Shimada K., Sekine S., et al. Pancreatic ducts as an important route of tumor extension for acinar cell carcinoma of the pancreas. Am J Surg Pathol 2010, 34:1025-1036.
8. Labate A.M., Klimstra D.L., Zakowski M.F. Comparative cytologic features of pancreatic acinar cell carcinoma and islet cell tumor. Diagn Cytopathol 1997, 16:112-116.
9. Klimstra D.S., Rosai J., Heffess C.S. Mixed acinar-endocrine carcinomas of the pancreas. Am J Surg Pathol 1994, 18:765-778.
10. La Rosa S., Franzi F., Marchet S., et al. The monoclonal anti-BCL10 antibody (clone 331.1) is a sensitive and specific marker of pancreatic acinar cell carcinoma and pancreatic metaplasia. Virchows Arch 2009, 454:133-142.
11. Rinderknecht H. Pancreatic secretory enzymes. The pancreas: biology, pathobiology, and disease 1993, 219-251. Raven, New York. V.L.W. Go, E.P. DiMagno, J.D. Gardner (Eds.).
12. Lack E.E. Pancreas. Pathology of the pancreas, gallbladder, extrahepatic biliary tract and ampullary region 2003, 307-317. Oxford University Press, New York.
13. Abraham S.C., Wu T.T., Hruban R.H., et al. Genetic and immunohistochemical analysis of pancreatic acinar cell carcinoma: frequent allelic loss on chromosome 11p and alterations in the APC/beta-catenin pathway. Am J Pathol 2002, 160:953-962.
14. Antonello D., Gobbo S., Corbo V., Sipos B., Lemoine N.R., Scarpa A. Update on the molecular pathogenesis of pancreatic tumors other than common ductal adenocarcinoma. Pancreatology 2009, 9:25-33.
15. Cantrell B.B., Cubilla A.L., Erlandson R.A., Fortner J., Fitzgerald P.J. Acinar cell cystadenocarcinoma of human pancreas. Cancer 1981, 47:410-416.
16. Stamm B., Burger H., Hollinger A. Acinar cell cystadenocarcinoma of the pancreas. Cancer 1987, 60:2542-2547.
17. Colombo P., Arizzi C., Roncalli M. Acinar cell cystadenocarcinoma of the pancreas: report of rare case and review of the literature. Hum Pathol 2004, 35:1568-1571.
18. Huang Y., Cao Y.F., Lin J.L., Gao F., Li F. Acinar cell cystadenocarcinoma of the pancreas in a 4-year-old child. Pancreas 2006, 33:311-312.
19. Jena M., Shariff S., Jeyachandran P. Cystic variant of acinar cell carcinoma of the pancreas presenting as pseudo-pancreatic cyst. Indian J Pathol Microbiol 2010, 53:190-192.
20. Ohike N., Kosmahl M., Klppel G. Mixed acinar-endocrine carcinoma of the pancreas. A clinicopathological study and comparison with acinar-cell carcinoma. Virchows Arch 2004, 445:231-235.
21. Machado M.C., Machado M.A., Perini M.V., et al. Acinar cell carcinoma of the pancreas: is the absence of neuroendocrine component related to a more malignant behavior?. Hepatogastroenterology 2008, 55:708-710.
22. Roldo C., Missiaglia E., Hagan J.P., et al. MicroRNA expression abnormalities in pancreatic endocrine and acinar tumors are associated with distinctive pathologic features and clinical behavior. JClin Oncol 2006, 24:4677-4684.
23. Stelow E.B., Shaco-Levy R., Bao F., Garcia J., Klimstra D.S. Pancreatic acinar cell carcinomas with prominent ductal differentiation: mixed acinar ductal carcinoma and mixed acinar endocrine ductal carcinoma. Am J Surg Pathol 2010, 34:510-518.
24. World Health Organization classification of tumours of the digestive system 2010, WHO Press, Geneva. 4th edn. F.T. Bosman, F. Carneiro, R.H. Hruban, N.D. Theise (Eds.).
25. Notohara K., Hamazaki S., Tsukayama C., et al. Solid-pseudopapillary tumor of the pancreas: immunohistochemical localization of neuroendocrine markers and CD10. Am J Surg Pathol 2000, 24:1361-1371.
26. Comper F., Antonello D., Beghelli S., et al. Expression pattern of claudins 5 and 7 distinguishes solid-pseudopapillary from pancreatoblastoma, acinar cell and endocrine tumors of the pancreas. Am J Surg Pathol 2009, 33:768-774.
27. Klimstra D.S., Wenig B.M., Adair C.F., Heffess C.S. Pancreatoblastoma. A clinicopathologic study and review of the literature. Am J Surg Pathol 1995, 19:1371-1389.
28. Klimstra D.S., Adsay N.V., Dhall D., et al. Intraductal tubular carcinoma of the pancreas: clinicopathologic and immunohistochemical analysis of 18 cases. Mod Pathol 2007, 20:285A.
29. Yamaguchi H., Shimizu M., Ban S., et al. Intraductal tubulopapillary neoplasms of the pancreas distinct from pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2009, 33:1164-1172.
30. Edge S.B., Byrd D.R., Compton C.C., Fritz A.G., Greene F.L., Trotti A. AJCC cancer staging manual 2010, Springer, New York. 7th edn.
31. Kitagami H., Kondo S., Hirano S., Kawakami H., Egawa S., Tanaka M. Acinar cell carcinoma of the pancreas: clinical analysis of 115 patients from Pancreatic Cancer Registry of Japan Pancreas Society. Pancreas 2007, 35:42-46.
32. Matos J.M., Schmidt C.M., Turrini O., et al. Pancreatic acinar cell carcinoma: a multi-institutional study. JGastrointest Surg 2009, 13:1495-1502.
33. Schmidt C.M., Matos J.M., Bentrem D.J., Talamonti M.S., Lillemoe K.D., Bilimoria K.Y. Acinar cell carcinoma of the pancreas in the United States: prognostic factors and comparison to ductal adenocarcinoma. JGastrointest Surg 2008, 12:2078-2086.
34. Vakiani E., Young R.H., Carcangiu M.L., Klimstra D.S. Acinar cell carcinoma of the pancreas metastatic to the ovary: a report of 4 cases. Am J Surg Pathol 2008, 32:1540-1545.
35. Wisnoski N.C., Townsend C.M., Nealon W.H., Freeman J.L., Riall T.S. 672 Patients with acinar cell carcinoma of the pancreas: a population-based comparison to pancreatic adenocarcinoma. Surgery 2008, 144:141-148.