Characterization and expression analysis in the developing embryonic brain of the porcine FET family: FUS, EWS, and TAF15

Gene

Volumn 493, Issue 1, 2012, Pages 27-35

  Blechingberg, Jenny ^a   Holm, Ida Elisabeth ^b   Nielsen, Anders Lade ^a  

^a AARHUS UNIVERSITY   (Denmark)

^b RANDERS REGIONAL HOSPITAL   (Denmark)

Author keywords

Animal model; Developing brain; Human disease; RNA binding; Transcription factor

Indexed keywords

AMINO ACID; BRAIN PROTEIN; FET PROTEIN; FUS PROTEIN; MESSENGER RNA; RNA BINDING PROTEIN EWS; TAF15 PROTEIN; UNCLASSIFIED DRUG;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BASAL GANGLION; BRAIN DEVELOPMENT; BRAIN STEM; CELL CULTURE; CEREBELLUM; EMBRYO; EXPERIMENTAL PIG; FETUS; GENE MUTATION; HIPPOCAMPUS; HUMAN; NEURAL STEM CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN LOCALIZATION;

AMINO ACID SEQUENCE; ANIMALS; BRAIN; CONSERVED SEQUENCE; EMBRYONIC DEVELOPMENT; HUMANS; MODELS, ANIMAL; RNA-BINDING PROTEIN EWS; RNA-BINDING PROTEIN FUS; SEQUENCE ALIGNMENT; SWINE; TATA-BINDING PROTEIN ASSOCIATED FACTORS;

ANIMALIA; SUIDAE; SUS;

EID: 84655167803     PISSN: 03781119     EISSN: 18790038     Source Type: Journal    
DOI: 10.1016/j.gene.2011.11.038     Document Type: Article

References (41)

1. Andersson M.K., et al. The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response. BMC Cell Biol. 2008, 9:37.
2. Azuma M., Embree L.J., Sabaawy H., Hickstein D.D. Ewing sarcoma protein ewsr1 maintains mitotic integrity and proneural cell survival in the zebrafish embryo. PLoS One 2007, 2:e979.
3. Baechtold H., Kuroda M., Sok J., Ron D., Lopez B.S., Akhmedov A.T. Human 75-kDa DNA-pairing protein is identical to the pro-oncoprotein TLS/FUS and is able to promote D-loop formation. J. Biol. Chem. 1999, 274:34337-34342.
4. Belly A., Bodon G., Blot B., Bouron A., Sadoul R., Goldberg Y. CHMP2B mutants linked to frontotemporal dementia impair maturation of dendritic spines. J. Cell Sci. 2010, 123:2943-2954.
5. Belly A., Moreau-Gachelin F., Sadoul R., Goldberg Y. Delocalization of the multifunctional RNA splicing factor TLS/FUS in hippocampal neurones: exclusion from the nucleus and accumulation in dendritic granules and spine heads. Neurosci. Lett. 2005, 379:152-157.
6. Bertolotti A., Bell B., Tora L. The N-terminal domain of human TAFII68 displays transactivation and oncogenic properties. Oncogene 1999, 18:8000-8010.
7. Bertolotti A., Lutz Y., Heard D.J., Chambon P., Tora L. hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II. EMBO J. 1996, 15:5022-5031.
8. Bertolotti A., Melot T., Acker J., Vigneron M., Delattre O., Tora L. EWS, but not EWS-FLI-1, is associated with both TFIID and RNA polymerase II: interactions between two members of the TET family, EWS and hTAFII68, and subunits of TFIID and RNA polymerase II complexes. Mol. Cell. Biol. 1998, 18:1489-1497.
9. Blechingberg J., Holm I.E., Johansen M.G., Børglum A.D., Nielsen A.L. Aromatic l-amino acid decarboxylase expression profiling and isoform detection in the developing porcine brain. Brain Res. 2010, 1308:1-13.
10. Crozat A., Aman P., Mandahl N., Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993, 363:640-644.
11. Delattre O., et al. Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours. Nature 1992, 359:162-165.
12. Deng H.X., et al. FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis. Ann. Neurol. 2010, 67:739-748.
13. Doi H., Koyano S., Suzuki Y., Nukina N., Kuroiwa Y. The RNA-binding protein FUS/TLS is a common aggregate-interacting protein in polyglutamine diseases. Neurosci. Res. 2010, 66:131-133.
14. Doi H., et al. RNA-binding protein TLS is a major nuclear aggregate-interacting protein in huntingtin exon 1 with expanded polyglutamine-expressing cells. J. Biol. Chem. 2008, 283:6489-6500.
15. Fujii R., et al. The RNA binding protein TLS is translocated to dendritic spines by mGluR5 activation and regulates spine morphology. Curr. Biol. 2005, 15:587-593.
16. Fujii R., Takumi T. TLS facilitates transport of mRNA encoding an actin-stabilizing protein to dendritic spines. J. Cell Sci. 2005, 118:5755-5765.
17. Gardiner M., Toth R., Vandermoere F., Morrice N.A., Rouse J. Identification and characterization of FUS/TLS as a new target of ATM. Biochem. J. 2008, 415:297-307.
18. Guipaud O., et al. An in vitro enzymatic assay coupled to proteomics analysis reveals a new DNA processing activity for Ewing sarcoma and TAF(II)68 proteins. Proteomics 2006, 6:5962-5972.
19. Hackl W., Luhrmann R. Molecular cloning and subcellular localisation of the snRNP-associated protein 69KD, a structural homologue of the proto-oncoproteins TLS and EWS with RNA and DNA-binding properties. J. Mol. Biol. 1996, 264:843-851.
20. Kanai Y., Dohmae N., Hirokawa N. Kinesin transports RNA: isolation and characterization of an RNA-transporting granule. Neuron 2004, 43:513-525.
21. Kwiatkowski T.J., et al. Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis. Science 2009, 323:1205-1208.
22. Mackenzie I.R., Rademakers R., Neumann M. TDP-43 and FUS in amyotrophic lateral sclerosis and frontotemporal dementia. Lancet Neurol. 2010, 9:995-1007.
23. Meissner M., Lopato S., Gotzmann J., Sauermann G., Barta A. Proto-oncoprotein TLS/FUS is associated to the nuclear matrix and complexed with splicing factors PTB, SRm160, and SR proteins. Exp. Cell Res. 2003, 283:184-195.
24. Morohoshi F., et al. Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes. Gene 1998, 221:191-198.
25. Neumann M., et al. FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain 2011, 134:2595-2609.
26. Neumann M., Rademakers R., Roeber S., Baker M., Kretzschmar H.A., Mackenzie I.R. A new subtype of frontotemporal lobar degeneration with FUS pathology. Brain 2009, 132:2922-2931.
27. Nguyen C.D., et al. Characterization of a family of RanBP2-Type zinc fingers that can recognize single-stranded RNA. J. Mol. Biol. 2011, 407:273-283.
28. Ohno T., Ouchida M., Lee L., Gatalica Z., Rao V.N., Reddy E.S. The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel regulatory domains. Oncogene 1994, 9:3087-3097.
29. Perrotti D., et al. TLS/FUS, a pro-oncogene involved in multiple chromosomal translocations, is a novel regulator of BCR/ABL-mediated leukemogenesis. EMBO J. 1998, 17:4442-4455.
30. Riggi N., Cironi L., Suva M.L., Stamenkovic I. Sarcomas: genetics, signalling, and cellular origins. Part 1: the fellowship of TET. J. Pathol. 2007, 213:4-20.
31. Sjogren H., Meis-Kindblom J., Kindblom L.G., Aman P., Stenman G. Fusion of the EWS-related gene TAF2N to TEC in extraskeletal myxoid chondrosarcoma. Cancer Res. 1999, 59:5064-5067.
32. Tan A.Y., Manley J.L. The TET family of proteins: functions and roles in disease. J. Mol. Cell Biol. 2009, 1:82-92.
33. Thomsen R., Solvsten C.A., Linnet T.E., Blechingberg J., Nielsen A.L. Analysis of qPCR data by converting exponentially related Ct values into linearly related X0 values. J. Bioinform. Comput. Biol. 2010, 8:885-900.
34. Ticozzi N., et al. Mutational analysis reveals the FUS homolog TAF15 as a candidate gene for familial amyotrophic lateral sclerosis. Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011.
35. Vance C., et al. Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6. Science 2009, 323:1208-1211.
36. Wang X., et al. Induced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcription. Nature 2008, 454:126-130.
37. Woulfe J., Gray D.A., Mackenzie I.R. FUS-immunoreactive intranuclear inclusions in neurodegenerative disease. Brain Pathol. 2010, 20:589-597.
38. Young P.J., Francis J.W., Lince D., Coon K., Androphy E.J., Lorson C.L. The Ewing's sarcoma protein interacts with the Tudor domain of the survival motor neuron protein. Brain Res. Mol. Brain Res. 2003, 119:37-49.
39. Zakaryan R.P., Gehring H. Identification and characterization of the nuclear localization/retention signal in the EWS proto-oncoprotein. J. Mol. Biol. 2006, 363:27-38.
40. Zinszner H., Albalat R., Ron D. A novel effector domain from the RNA-binding protein TLS or EWS is required for oncogenic transformation by CHOP. Genes Dev. 1994, 8:2513-2526.
41. Zinszner H., Sok J., Immanuel D., Yin Y., Ron D. TLS (FUS) binds RNA in vivo and engages in nucleo-cytoplasmic shuttling. J. Cell Sci. 1997, 110(Pt 15):1741-1750.