Microparticle number or procoagulant activity are not upregulated in healthy elderly persons

Thrombosis Research

Volumn 129, Issue 1, 2012, Pages 98-100

  Emmerechts, J ^a   Loyen, S ^a   Hoylaerts, M F ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTITHROMBIN; BLOOD CLOTTING FACTOR 7; BLOOD CLOTTING FACTOR 8; BLOOD CLOTTING FACTOR 9; D DIMER; FIBRINOGEN; HOMOCYSTEINE; PHOSPHOLIPID; PLASMINOGEN ACTIVATOR INHIBITOR; PROCOAGULANT; PROTEIN C; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR;

AGING; BLOOD CLOTTING; COMORBIDITY; DEEP VEIN THROMBOSIS; ENDOTHELIAL DYSFUNCTION; ERYTHROCYTE; FIBRINOGEN BLOOD LEVEL; HEMOSTASIS; HORMONE SUBSTITUTION; HUMAN; LETTER; MICROPARTICLE; PARTIAL THROMBOPLASTIN TIME; PARTICLE SIZE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTHROMBIN TIME; QUESTIONNAIRE; RISK FACTOR; UPREGULATION;

ADULT; AGE FACTORS; AGED, 80 AND OVER; AGING; ANTITHROMBIN PROTEINS; BELGIUM; BIOLOGICAL MARKERS; BLOOD COAGULATION; CELL-DERIVED MICROPARTICLES; FACTOR VII; FACTOR VIII; FEMALE; FIBRINOGEN; FLOW CYTOMETRY; HUMANS; MALE; PARTIAL THROMBOPLASTIN TIME; PILOT PROJECTS; PROTEIN C; PROTHROMBIN TIME;

EID: 84655167025     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2011.09.006     Document Type: Letter

References (17)

1. I.A. Naess, S.C. Christiansen, P. Romundstad, S.C. Cannegieter, F.R. Rosendaal, and J. Hammerstrom Incidence and mortality of venous thrombosis: a population-based study J Thromb Haemost 5 4 Apr 2007 692 699 (Pubitemid 46563566)
2. M.J. Engbers, A. van Hylckama Vlieg, and F.R. Rosendaal Venous thrombosis in the elderly: incidence, risk factors and risk groups J Thromb Haemost 8 10 Oct 2010 2105 2112
3. D. Mari, P.M. Mannucci, R. Coppola, B. Bottasso, K.A. Bauer, and R.D. Rosenberg Hypercoagulability in centenarians: the paradox of successful aging Blood 85 11 Jun 1 1995 3144 3149
4. W.R. Wilkerson, and D.C. Sane Aging and thrombosis Semin Thromb Hemost 28 6 Dec 2002 555 568
5. F.R. Rosendaal, A. VANHV, and C.J. Doggen Venous thrombosis in the elderly J Thromb Haemost 5 Suppl. 1 Jul 2007 310 317 (Pubitemid 46958848)
6. O. Morel, F. Toti, B. Hugel, B. Bakouboula, L. Camoin-Jau, and F. Dignat-George Procoagulant microparticles: disrupting the vascular homeostasis equation? Arterioscler Thromb Vasc Biol 26 12 Dec 2006 2594 2604
7. J.A. Chirinos, G.A. Heresi, H. Velasquez, W. Jy, J.J. Jimenez, and E. Ahn Elevation of endothelial microparticles, platelets, and leukocyte activation in patients with venous thromboembolism J Am Coll Cardiol 45 9 May 3 2005 1467 1471 (Pubitemid 40615620)
8. V. Ollivier, J. Wang, D. Manly, K.R. Machlus, A.S. Wolberg, and M. Jandrot-Perrus Detection of endogenous tissue factor levels in plasma using the calibrated automated thrombogram assay Thromb Res 125 1 Jan 2010 90 96
9. R. Lacroix, S. Robert, P. Poncelet, R.S. Kasthuri, N.S. Key, and F. Dignat-George Standardization of platelet-derived microparticle enumeration by flow cytometry with calibrated beads: results of the International Society on Thrombosis and Haemostasis SSC Collaborative workshop J Thromb Haemost 8 11 Nov 2010 2571 2574
10. E. Dey-Hazra, B. Hertel, T. Kirsch, A. Woywodt, S. Lovric, and H. Haller Detection of circulating microparticles by flow cytometry: influence of centrifugation, filtration of buffer, and freezing Vasc Health Risk Manag 6 2010 1125 1133
11. M.D. Shah, A.L. Bergeron, J.F. Dong, and J.A. Lopez Flow cytometric measurement of microparticles: pitfalls and protocol modifications Platelets 19 5 Aug 2008 365 372
12. D.E. Connor, T. Exner, D.D. Ma, and J.E. Joseph The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib Thromb Haemost 103 5 May 2010 1044 1052
13. R.P. Tracy, E.G. Bovill, L.P. Fried, G. Heiss, M.H. Lee, and J.F. Polak The distribution of coagulation factors VII and VIII and fibrinogen in adults over 65 years. Results from the Cardiovascular Health Study Ann Epidemiol 2 4 Jul 1992 509 519
14. R.P. Tracy, E.G. Bovill, D. Yanez, B.M. Psaty, L.P. Fried, and G. Heiss Fibrinogen and factor VIII, but not factor VII, are associated with measures of subclinical cardiovascular disease in the elderly. Results from The Cardiovascular Health Study Arterioscler Thromb Vasc Biol 15 9 Sep 1995 1269 1279
15. M.G. Conlan, A.R. Folsom, A. Finch, C.E. Davis, P. Sorlie, and G. Marcucci Associations of factor VIII and von Willebrand factor with age, race, sex, and risk factors for atherosclerosis. The Atherosclerosis Risk in Communities (ARIC) Study Thromb Haemost 70 3 Sep 1 1993 380 385 (Pubitemid 23254660)
16. A. Forest, E. Pautas, P. Ray, D. Bonnet, M. Verny, and N. Amabile Circulating microparticles and procoagulant activity in elderly patients J Gerontol A Biol Sci Med Sci 65 4 Apr 2010 414 420
17. B.A. Owen, A. Xue, J.A. Heit, and W.G. Owen Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism Thromb Res 127 1 Jan 2011 39 46