Ibuprofen-phospholipid solid dispersions: Improved dissolution and gastric tolerance

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 290-294

  Hussain, M Delwar ^a   Saxena, Vipin ^a   Brausch, James F ^a   Talukder, Rahmat M ^b  

^a TEXAS A AND M UNIVERSITY KINGSVILLE   (United States)

^b SOUTHWESTERN OKLAHOMA STATE UNIVERSITY   (United States)

Author keywords

Dissolution; Gastrointestinal toxicity; Ibuprofen; Phospholipids; Solid dispersion

Indexed keywords

ALCOHOL; CHLOROFORM; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DIMYRISTOYLPHOSPHATIDYLGLYCEROL; DIPALMITOYLPHOSPHATIDYLCHOLINE; IBUPROFEN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DISPERSION; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG SOLUBILITY; GASTROINTESTINAL TOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; STOMACH MUCOSA; X RAY DIFFRACTION;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CHEMISTRY, PHARMACEUTICAL; CHLOROFORM; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; CYTOPROTECTION; DIMYRISTOYLPHOSPHATIDYLCHOLINE; DRUG CARRIERS; DRUG COMPOUNDING; ETHANOL; GASTRIC MUCOSA; IBUPROFEN; MALE; MICROSCOPY, ELECTRON, SCANNING; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLGLYCEROLS; PHOSPHOLIPIDS; POWDER DIFFRACTION; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SOLVENTS; STOMACH ULCER; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 84655166568     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.11.011     Document Type: Article

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