Are these patients indeed resistant to treatment with C1 inhibitor concentrate?

British Journal of Dermatology

Volumn 166, Issue 1, 2012, Pages 225-226

  Varga, L ^a   Fust G ^a   Farkas, H ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

Author keywords

[No Author keywords available]

Indexed keywords

C1 INHIBITOR CONCENTRATE; DERMATOLOGICAL AGENT; ICATIBANT; UNCLASSIFIED DRUG;

ANGIONEUROTIC EDEMA; ANTIBODY TITER; CLINICAL FEATURE; DISEASE SEVERITY; DRUG DOSE ESCALATION; DRUG EFFICACY; FOLLOW UP; HASHIMOTO DISEASE; HUMAN; LETTER; PRIORITY JOURNAL;

BRADYKININ; COMPLEMENT C1 INHIBITOR PROTEIN; FEMALE; HEREDITARY ANGIOEDEMA TYPES I AND II; HUMANS; RECEPTORS, BRADYKININ;

EID: 84655162741     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2011.10522.x     Document Type: Letter

References (7)

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2. U.S. Food and Drug Administration. Cinryze. Available at: (last accessed 16 August 2011).
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4. Varga L, Szeplaki G, Visy B, et al. C1-inhibitor (C1-INH) autoantibodies in hereditary angioedema. Strong correlation with the severity of disease in C1-INH concentrate naive patients. Mol Immunol 2007; 44: 1454-60. (Pubitemid 44415947)
5. Donaldson VH, Bissler JJ, Welch TR, et al. Antibody to C1-inhibitor in a patient receiving C1-inhibitor infusions for treatment of hereditary angioneurotic edema with systemic lupus erythematosus reacts with a normal allotype of residue 458 of C1-inhibitor. J Lab Clin Med 1996; 128: 438-43. (Pubitemid 27506932)
6. Bork K, Hardt J,. Hereditary angioedema: long-term treatment with one or more injections of C1 inhibitor concentrate per week. Int Arch Allergy Immunol 2011; 154: 81-8.
7. Bork K, Hardt J,. Hereditary angioedema: increased number of attacks after frequent treatments with C1 inhibitor concentrate. Am J Med 2009; 122: 780-3.