Genetic variant of HTR2A associates with risk of impulse control and repetitive behaviors in Parkinson's disease

Parkinsonism and Related Disorders

Volumn 18, Issue 1, 2012, Pages 76-78

  Lee, Jee Young ^a,b   Jeon, Beom S ^b,c   Kim, Han Joon ^b,c   Park, Sung Sup ^b  

^a Seoul National University Boramae Hospital   (South Korea)

^b Seoul National University Hospital   (South Korea)

^c Seoul National University College of Medicine   (South Korea)

Author keywords

Impulse control and repetitive behaviors; Parkinson's disease; Serotonin 2A receptor

Indexed keywords

DOPAMINE RECEPTOR STIMULATING AGENT; LEVODOPA;

AGE; ARTICLE; COHORT ANALYSIS; COMPULSION; CONTROLLED STUDY; DOSE RESPONSE; DRUG USE; GENE EXPRESSION; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; HETEROZYGOTE; HIGH RISK PATIENT; HUMAN; IMPULSE CONTROL DISORDER; INTERVIEW; MAJOR CLINICAL STUDY; NEUROPATHOLOGY; ONSET AGE; PARKINSON DISEASE; PRIORITY JOURNAL; RECEPTOR GENE; RISK ASSESSMENT; SCREENING TEST; SEROTONIN 2A RECEPTOR GENE; SEX;

AGED; CASE-CONTROL STUDIES; COHORT STUDIES; CUMULATIVE TRAUMA DISORDERS; FEMALE; GENETIC ASSOCIATION STUDIES; GENETIC PREDISPOSITION TO DISEASE; GENETIC VARIATION; HUMANS; IMPULSE CONTROL DISORDERS; MALE; MIDDLE AGED; PARKINSON DISEASE; RECEPTOR, SEROTONIN, 5-HT2A; RISK FACTORS;

EID: 84655161539     PISSN: 13538020     EISSN: 18735126     Source Type: Journal    
DOI: 10.1016/j.parkreldis.2011.08.009     Document Type: Article

References (12)

1. Voon V., Fox S.H. Medication-related impulse control and repetitive behaviors in Parkinson disease. Arch Neurol 2007, 64:1089-1096.
2. Lee J.Y., Lee E.K., Park S.S., Lim J.Y., Kim H.J., Kim J.S., et al. Association of DRD3 and GRIN2B with impulse control and related behaviors in Parkinson disease. Mov Disord 2009, 24:1803-1810.
3. Weintraub D., Koester J., Potenza M.N., Siderowf A.D., Stacy M., Voon V., et al. Impulse control disorders in Parkinson disease: a cross-sectional study of 3090 patients. Arch Neurol 2010, 67:589-595.
4. Brewer J.A., Potenza M.N. The neurobiology and genetics of impulse control disorders: relationships to drug addictions. Biochem Pharmacol 2008, 75:63-75.
5. Kreek M.J., Nielsen D.A., Butelman E.R., LaForge K.S. Genetic influences on impulsivity, risk taking, stress responsivity and vulnerability to drug abuse and addiction. Nat Neurosci 2005, 8:1450-1457.
6. Nomura M., Kusumi I., Kaneko M., Masui T., Daiguji M., Ueno T., et al. Involvement of a polymorphism in the 5-HT2A receptor gene in impulsive behavior. Psychopharmacology (Berl) 2006, 187:30-35.
7. 2A receptor gene polymorphisms. Eur Addic Res 2008, 14:47-52.
8. Kim B., Choi E.Y., Kim C.Y., Song K., Joo Y.H. Could HTR2A T102C and DRD3 Ser9Gly predict clinical improvement in patients with acutely exacerbated schizophrenia? Results from treatment responses to risperidone in a naturalistic setting. Hum Psychopharmacol Clin Exp 2008, 23:61-67.
9. Winstanley C.A., Theobald D.E., Dalley J.W., Robbins T.W. Interactions between serotonin and dopamine in the control of impulsive choice in rats: therapeutic implications for impulse control disorders. Neuropsychopharmacology 2005, 30:669-682.
10. Li T., Liu X., Zhao J., Hu X., Ball D.M., Loh el.-W., et al. Allelic association analysis of the dopamine D2, D3, 5-HT2A, and GABA(A)gamma2 receptors and serotonin transporter genes with heroin abuse in Chinese subjects. Am J Med Genet 2002, 114:329-335.
11. Polesskaya O.O., Sokolov B.P. Differential expression of the " C" and " T" alleles of the 5-HT2A receptor gene in the temporal cortex of normal individuals and schizophrenics. JNeurosci Res 2002, 67:812-822.
12. Myers R.L., Airey D.C., Manier D.H., Shelton R.C., Sanders-Bush E. Polymorphisms in the regulatory region of the human serotonin 5-HT2A receptor gene (HTR2A) influence gene expression. Biol Psychiatry 2007, 61:167-173.