Companion drugs for amphotericin B in cryptococcal meningitis: Flucytosine, fluconazole, or..Nothing?

Clinical Infectious Diseases

Volumn 54, Issue 1, 2012, Pages 129-130

  Bennett, John ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMPHOTERICIN B; FLUCONAZOLE; FLUCYTOSINE; ITRACONAZOLE; VORICONAZOLE;

COMBINATION CHEMOTHERAPY; CRYPTOCOCCAL MENINGITIS; HUMAN; MONOTHERAPY; NOTE; PRIORITY JOURNAL;

ANTIFUNGAL AGENTS; FEMALE; HIV INFECTIONS; HUMANS; MALE; MENINGITIS, CRYPTOCOCCAL;

EID: 84555206673     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/cir758     Document Type: Note

References (7)

1. Loyse A, Wilson D, Meintjes G, et al. Comparison of the early fungicidal activity of high dose fluconazole, voriconazole, and flucytosine, as second drug given in combination with amphotericin B, for the treatment of HIV-associated cryptococcal meningitis. Clin Infect Dis 2011; 54:121-8.
2. Perfect JR, Dismukes WE, Dromer F, et al. Clinical practice guidelines for the management of cryptococcal disease: 2010 update by the Infectious Diseases Society of America. Clin Infect Dis 2010; 50:291-322.
3. van der Horst CM, Saag MS, Cloud GA, et al. National Institute of Allergy and Infectious Diseases Mycoses Study Group and AIDS Clinical Trials Group. Treatment of cryptococcal meningitis associated with the acquired immunodeficiency syndrome. N Engl J Med 1997; 337:15-21.
4. Saag MS, Cloud GA, Graybill JR, et al. A comparison of itraconazole versus fluconazole as maintenance therapy for AIDSassociated cryptococcal meningitis. Clin Infect Dis 1999; 28:291-6.
5. Brouwer AE, Rajanuwong A, Chierakul W, et al. Combination antifungal therapies for HIV-associated cryptococcal meningitis: a randomized trial. Lancet 2004; 363:1764-7. (Pubitemid 38698379)
6. Bicanic T, Muzoora C, Brouwer AE, et al. Independent association between rate of clearance of infection and clinical outcome of HIVassociated cryptococcal meningitis: analysis of a combined cohort of 262 patients. Clin Infect Dis 2009; 49:702-9.
7. Bicanic T, Meintjes G, Wood R, et al. Fungal burden, early fungicidal activity, and outcome in cryptococcal meningitis in antiretroviralnaive or antiretroviral-experienced patients treated with amphotericin B or fluconazole. Clin Infect Dis 2007; 45:76-80. (Pubitemid 46984619)