Skin biopsy-proven flecainide-induced neuropathy

Muscle and Nerve

Volumn 45, Issue 1, 2012, Pages 144-146

  Burakgazi, Ahmet Z ^a   Polydefkis, Michael ^b   Höke, Ahmet ^b  

^a GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Flecainide; Peripheral neuropathy; Potassium channel; Skin biopsy; Toxic neuropathy

Indexed keywords

PERIPHERAL MYELIN PROTEIN 22;

ADULT; ARTICLE; CASE REPORT; CHROMOSOME 17P; CONTROLLED STUDY; ELECTROPHYSIOLOGY; EXON; GENE DELETION; GENETIC DISORDER; HUMAN; MALE; MOTOR NERVE; MULTIPLEX LIGATION DEPENDENT PROBE AMPLIFICATION; NERVE BIOPSY; NERVE CONDUCTION; NERVE FIBER; NEUROPATHY; PARALYSIS; PERIPHERAL NEUROPATHY; PHENOTYPE; PRESSURE PARALYSIS; PRIORITY JOURNAL; SENSORY NERVE; SENSORY NEUROPATHY; SKIN BIOPSY;

AGED; ANTI-ARRHYTHMIA AGENTS; BIOPSY; FLECAINIDE; HUMANS; MALE; PERIPHERAL NERVOUS SYSTEM DISEASES; SKIN;

EID: 84555195076     PISSN: 0148639X     EISSN: 10974598     Source Type: Journal    
DOI: 10.1002/mus.22239     Document Type: Article

References (12)

1. Flecainide for supraventricular tachyarrhythmias. Med Lett Drugs Ther 1992;34:71-72.
2. Aoike F, Takahashi MP, Sakoda S. Class Ic antiarrhythmics block human skeletal muscle Na channel during myotonia-like stimulation. Eur J Pharmacol 2006;532:24-31.
3. Antiarrhythmic Drug Evaluation Group (A.D.E.G.). A multicentre, randomized trial on the benefit/risk profile of amiodarone, flecainide and propafenone in patients with cardiac disease and complex ventricular arrhythmias. Eur Heart J 1992; 13:1251-1258.
4. Gentzkow GD, Sullivan JY. Extracardiac adverse effects of flecainide. Am J Cardiol 1984;53:101B-105B.
5. Palace J, Shah R, Clough C. Flecainide induced peripheral neuropathy. BMJ 1992;305:810.
6. Malesker MA, Sojka SG, Fagan NL. Flecainide-induced neuropathy. Ann Pharmacother 2005;39:1580.
7. The Collaborative Group for the Study of Polyneuropathy. Antiarrhythmic drugs and polyneuropathy. J Neurol Neurosurg Psychiatry 1994;57:340-343.
8. Bennett MI. Paranoid psychosis due to flecainide toxicity in malignant neuropathic pain. Pain 1997;70:93-94.
9. Ting SM, Lee D, Maclean D, Sheerin NS. Paranoid psychosis and myoclonus: flecainide toxicity in renal failure. Cardiology 2008;111: 83-86.
10. Bocksteins E, Raes AL, van de Vijver G, Bruyns T, van Bogaert PP, Snyders DJ. Kv2.1 and silent Kv subunits underlie the delayed rectifier K{thorn} current in cultured small mouse DRG neurons. Am J Physiol Cell Physiol 2009;296:C1271-C1278.
11. Caballero R, Dolz-Gaiton P, Gomez R, Amoros I, Barana A, Gonzalez de la Fuente M, et al. Flecainide increases Kir2.1 currents by interacting with cysteine 311, decreasing the polyamine-induced rectification. Proc Natl Acad Sci USA 2010;107:15631-15636.
12. Cao XH, Byun HS, Chen SR, Cai YQ, Pan HL. Reduction in voltagegated K{thorn} channel activity in primary sensory neurons in painful diabetic neuropathy: role of brain-derived neurotrophic factor. J Neurochem 2010;114:1460-1475.