HTLV-2 APH-2 expression is correlated with proviral load but APH-2 does not promote lymphocytosis

Journal of Infectious Diseases

Volumn 205, Issue 1, 2012, Pages 82-86

  Douceron, Estelle ^a,b,c   Kaidarova, Zhanna ^d   Miyazato, Paola ^e   Matsuoka, Masao ^e   Murphy, Edward L ^d   Mahieux, Renaud ^a,b,c  

^a CENTRE INTERNATIONAL DE RECHERCHE EN INFECTIOLOGIE   (France)

^b UNIVERSITÉ DE LYON   (France)

^c University Lyon i   (France)

^d BLOOD SYSTEMS RESEARCH INSTITUTE   (United States)

^e KYOTO UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE PROTEIN OF HUMAN T CELL LEUKEMIA VIRUS 2; TAX PROTEIN; UNCLASSIFIED DRUG; VIRUS PROTEIN;

ADULT; AGED; ARTICLE; BLOOD SAMPLING; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 2; IN VITRO STUDY; IN VIVO STUDY; LYMPHOCYTE COUNT; LYMPHOCYTE PROLIFERATION; LYMPHOCYTOSIS; MALE; PRIORITY JOURNAL; PROVIRAL LOAD; VIRUS LOAD;

ADULT; AGED; AGED, 80 AND OVER; ASYMPTOMATIC INFECTIONS; COHORT STUDIES; FEMALE; GENE PRODUCTS, TAX; HTLV-II INFECTIONS; HUMAN T-LYMPHOTROPIC VIRUS 2; HUMANS; LINEAR MODELS; LYMPHOCYTOSIS; MALE; MIDDLE AGED; PROVIRUSES; RETROVIRIDAE PROTEINS; VIRAL LOAD;

EID: 84555189220     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1093/infdis/jir708     Document Type: Article

References (14)

1. Journo C, Douceron E, Mahieux R. HTLV gene regulation: because size matters, transcription is not enough. Future Microbiol 2009; 4:425-40.
2. Gaudray G, Gachon F, Basbous J, Biard-Piechaczyk M, Devaux C, Mesnard JM. The complementary strand of the human T-cell leukemia virus type 1 RNA genome encodes a bZIP transcription factor that down-regulates viral transcription. J Virol 2002; 76:12813-22. (Pubitemid 35386965)
3. Halin M, Douceron E, Clerc I, et al. Human T-cell leukemia virus type 2 produces a spliced antisense transcript encoding a protein that lacks a classic bZIP domain but still inhibits Tax2-mediated transcription. Blood 2009; 114:2427-38.
4. Bartman MT, Kaidarova Z, Hirschkorn D, et al. Long-term increases in lymphocytes and platelets in human T-lymphotropic virus type II infection. Blood 2008; 112:3995-4002.
5. Satou Y, Yasunaga J, Yoshida M, Matsuoka M. HTLV-I basic leucine zipper factor gene mRNA supports proliferation of adult T cell leukemia cells. Proc Natl Acad Sci USA 2006; 103:720-5. (Pubitemid 43153092)
6. Saito M, Matsuzaki T, Satou Y, et al. In visvo expression of the HBZ gene of HTLV-1 correlates with proviral load, inflammatory markers and disease severity in HTLV-1 associated myelopathy/tropical spastic paraparesis (HAM/TSP). Retrovirology 2009; 6:19.
7. Usui T, Yanagihara K, Tsukasaki K, et al. Characteristic expression of HTLV-1 basic zipper factor (HBZ) transcripts in HTLV-1 proviruspositive cells. Retrovirology 2008; 5:34.
8. Satou Y, Yasunaga J, Zhao T, et al. HTLV-1 bZIP factor induces T-cell lymphoma and systemic inflammation in vivo. PLoS Pathog 2011; 7:e1001274.
9. Matsuoka M, Green PL. The HBZ gene, a key player in HTLV-1 pathogenesis. Retrovirology 2009; 6:71.
10. Murphy EL, Glynn SA, Fridey J, et al. Increased prevalence of infectious diseases and other adverse outcomes in human T lymphotropic virus types I-and II-infected blood donors. Retrovirus Epidemiology Donor Study (REDS) Study Group. J Infect Dis 1997; 176:1468-75. (Pubitemid 27518145)
11. Kwaan N, Lee TH, Chafets DM, et al. Long-term variations in human T lymphotropic virus (HTLV)-I and HTLV-II proviral loads and association with clinical data. J Infect Dis 2006; 194:1557-64. (Pubitemid 44851897)
12. Lee TH, Chafets DM, Busch MP, Murphy EL. Quantitation of HTLV-I and II proviral load using real-time quantitative PCR with SYBR Green chemistry. J Clin Virol 2004; 31:275-82. (Pubitemid 39371060)
13. Besson G, Kazanji M. One-step, multiplex, real-time PCR assay with molecular beacon probes for simultaneous detection, differentiation, and quantification of human T-cell leukemia virus types 1, 2, and 3. J Clin Microbiol 2009; 47:1129-35.
14. Roucoux DF, Murphy EL. The epidemiology and disease outcomes of human T-lymphotropic virus type II. AIDS Rev 2004; 6:144-54. (Pubitemid 39599984)