Identification of 1,3-diiminoisoindoline carbohydrazides as potential antimalarial candidates

ChemMedChem

Volumn 7, Issue 1, 2012, Pages 151-158

  Mombelli, Paolo ^a   Witschel, Matthias C ^b   van Zijl, Anthoni W ^a   Geist, Julie G ^a   Rottmann, Matthias ^c,d   Freymond, Céline ^c,d   Röhl, Franz ^b   Kaiser, Marcel ^c,d   Illarionova, Victoria ^e   Fischer, Markus ^e   Siepe, Isabella ^b   Schweizer, W Bernd ^a   Brun, Reto ^c,d   Diederich, François ^a  

^a ETH ZURICH   (Switzerland)

^b BASF SE   (Germany)

^c SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

^e UNIVERSITY OF HAMBURG   (Germany)

Author keywords

Antiprotozoal agents; Biological activity; Herbicides; Isoindolines; Malaria

Indexed keywords

1,3 DIIMINOISOINDOLE CARBOHYDRAZIDE; ANTIMALARIAL AGENT; CHLORIDE; CHLOROQUINE; IRON COMPLEX; ISOINDOLE DERIVATIVE; LIGAND; TRIDENTATE LIGAND; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANTIMALARIAL ACTIVITY; ARTICLE; CELL ASSAY; COMPUTATIONAL FLUID DYNAMICS; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SOLUBILITY; DRUG SYNTHESIS; FEMALE; GROWTH INHIBITION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; IN VIVO STUDY; MALARIA FALCIPARUM; MOUSE; NONHUMAN; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; SINGLE DRUG DOSE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTIMALARIALS; CELL LINE; CELL SURVIVAL; HUMANS; HYDRAZINES; ISOINDOLES; MALARIA, FALCIPARUM; PLASMODIUM FALCIPARUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84555186670     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201100441     Document Type: Article

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