Heterozygous familial hypercholesterolaemic patients have increased arterial stiffness, as determined using the augmentation index

Journal of Atherosclerosis and Thrombosis

Volumn 18, Issue 12, 2011, Pages 1110-1116

  Plana, Nuria ^a   Ferré, Raimon ^a   Merino, Jordi ^a   Aragonès, Gemma ^a   Girona, Josefa ^a   And, Mercedes Heras ^a   Masana, Luis ^a  

^a HOSPITAL UNIVERSITARI SANT JOAN DE REUS   (Spain)

Author keywords

Apolipoprotein B100; Arterial stiffness; Augmentation index; Heterozygous familial hypercholesterolaemia; Intimae media thickness

Indexed keywords

APOLIPOPROTEIN B100; GLUCOSE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL;

ADULT; ANKLE BRACHIAL INDEX; ANTHROPOMETRY; ARTERIAL STIFFNESS; ARTERIAL WALL THICKNESS; ARTERY TONE; ARTICLE; AUGMENTATION INDEX; BIOCHEMISTRY; CARDIOVASCULAR RISK; CAROTID ARTERY; CONTROLLED STUDY; DISEASE ASSOCIATION; FAMILIAL HYPERCHOLESTEROLEMIA; FEMALE; GLUCOSE BLOOD LEVEL; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC PARAMETERS; SYSTOLIC BLOOD PRESSURE; TONOMETRY;

ADULT; ARTERIES; CASE-CONTROL STUDIES; COMPLIANCE; CROSS-SECTIONAL STUDIES; FEMALE; HETEROZYGOTE; HUMANS; HYPERLIPOPROTEINEMIA TYPE II; MALE; MIDDLE AGED;

EID: 84455210317     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.9795     Document Type: Article

References (28)

1. Goldstein JL, Hobbs HH, Brown MS. Familial hypercholesterolemia. In The metabolic and molecular bases of inherited disease, Ed 8. Edited by Scriver C, Beaudet A, Sly W, and Valle D. New York: McGraw-Hill; 2001; 2863-2913
2. de Groot E, Hovingh GK, Wiegman A, Duriez P, Smit AJ, Fruchart JC, Kastelein JJ: Measurement of arterial wall thickness as a surrogate marker for atherosclerosis. Circulation, 2004; 109: 33-38
3. Mohrschladt MF, Westendorp RG, Gevers Leuven JA, Smelt AH: Cardiovascular disease and mortality in statintreated patients with familial hypercholesterolemia. Atherosclerosis, 2004; 172: 329-335
4. Shepherd J, Cobbe SM, Ford I, Isles CG, Lorimer AR, MacFarlane PW, McKillop JH, Packard CJ: Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. N Engl J Med, 1995; 333: 1301-1307
5. Civeira F: International Panel on Management of Familial Hypercholesterolemia. Guidelines for the diagnosis and management of heterozygous familial hypercholesterolemia. Atherosclerosis, 2004; 173: 55-68
6. Schillinger M, Exner M, Mleukusch W, Amighi J, Sabeti S, Muellner M, Rumpold H, Wagner O, Minar E: Statin therapy improves cardiovascular outcomes of patients with peripheral arterial disease. Eur Heart J, 2004; 25: 742-748
7. Riggio S, Mandraffino G, Sardo MA, Ludicello R, Camarda N, Imbalzano E, Alibrandi A, Saitta C, Carerj S, Arrigo T, Saitta A: Pulse wave velocity and augmentation index, but not intima media thickness, are early indicators of vascular damage in hypercholesterolemic children. Eur J Clin Invest, 2010; 40: 250-257
8. Wendelhag I, Wiklund O, Wikstrand J: Atherosclerotic changes in the femoral and carotid arteries in familial hypercholesterolemia. Ultrasonographic assessment of intima-media thickness and plaque occurrence. Atheroscler Tromb, 1993; 13: 1404-1411
9. Lane HA, Smith JC, Davies JS: Noninvasive assessment of preclinical atherosclerosis. Vasc Health Risk Man, 2006; 2: 19-30
10. Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, Jeppesen J: Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation, 2006; 113: 664-670
11. Glasser SP, Arnett DK, McVeigh GE, Finkelstein SM, Bank A, Morgan D, Cohn JN: Vascular compliance and cardiovascular disease: a risk factor or a marker? Am J Hypertens, 1997; 10: 1175-1189
12. Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, Vita JA, Lewy D, Benjamin EJ: Arterial stiffness and cardiovascular events: The Framingham Heart Study. Circulation, 2010; 121: 505-511
13. Lehmann ED, Hopkins KD, Gosling RG: Aortic compliance measurements using Doppler ultrasound: in vivo biochemical correlates. Ultrasound Med Biol, 1993; 19: 683-710
14. Cameron JD, Jennings GL, Dart AM: The relationship between arterial compliance, age, blood pressure and serum lipid levels. J Hypertens, 1995; 13: 1718-1723
15. Cecelja M, Chowienczyk P: Dissociation of aortic pulse wave velocity with risk factors for cardiovascular disease other than hypertension. Hypertension, 2009; 54: 1328-1336
16. Williams RR, Hunt SC, Schumacher MC, Hegele RA, Leppert MF, Ludwig EH, Hopkins PN: Diagnosing heterozygous familial hypercholesterolemia using new practical criteria validated by molecular genetics. Am J Cardiol, 1993; 72: 171-176
17. Stein JH, Korcarz CE, Hurst RT, Lonn E, Kendall CB, Mohler ER, Najjar SS, Rembold CM, Post WS: Use of carotid ultrasound to identify subclinical vascular disease and evaluate cardiovascular disease risk: a consensus statement from the American Society of Echocardiography Carotid Intima-Media Thickness Task Force. Endorsed by the Society for Vascular Medicine. J Am Soc Echocar-diogr, 2008; 21: 93-111
18. Laurent S, Katsahian S, Fassot C, Tropeano AI, Gautier I, Laloux B, Boutouyrie P: Aortic stiffness is an independent predictor of fatal stroke in essential hypertension. Stroke, 2003; 34: 1203-1206
19. Mattace-Raso FU, van der Cammen TJ, Hofman A, van Popele NM, Bos ML, Schalekamp MA, Asmar R, Reneman RS, Hoeks AP, Breteler MM, Witteman JC: Arterial stiffness and risk of coronary heart disease and stroke: The Rotterdam Study. Circulation, 2006; 113: 657-663
20. Laurent S, Cockcroft J, van Bortel L, Boutouyrie P, Giannasttasio C, Hayoz D, Pannier B, Vlachopoulos C, Wilkinson I, Struijker-Boudier H: Expert consensus document on arterial stiffness: methodological issues and clinical applications. Eur Heart J, 2006; 21: 2588-2605
21. Farrar DJ, Bond MG, Riley WA, Sawyer JK: Anatomic correlates of aortic pulse wave velocity and carotid artery elasticity during atherosclerosis progression and regression in monkeys. Circulation, 1991; 83: 1754-1763
22. Pitsavos C, Toutouzas K, Dernellis J, Skoumas J, Skoumbourdis E, Stefanidis C, Toutouzas P: Aortic stiffness in young patients with heterozygous familial hypercholesterolemia. Am Heart J, 1998; 135: 604-608
23. Smilde TJ, van der Berkmortel FW, Wollersheim H, van Langen H, Kastelein JJ, Stalenhoef AF: The effect of cholesterol lowering on carotid and femoral artery wall stiffness and thickness in patients with familial hypercholesterolaemia. Eur J Clin Invest, 2000; 30: 473-480
24. Masoura C, Pitsavos C, Aznaouridis K, Skoumas I, Vlachopoulos C, Stefanidis C: Arterial endothelial function and wall thickness in familial hypercholesterolemia and familial combined hyperlipidemia and the effect of statins. A systematic review and meta-analysis. Atherosclerosis, 2010; 214: 129-138
25. Toikka JO, Niemi P, Ahotupa M, Ninikoski H, Viikari JS, Ronnemaa T, Hartiala JJ, Raitakari OT: Large-artery elastic properties in young men: relationships to serum lipoproteins and oxidized low-density lipoproteins. Atheroscler Tromb Vasc Biol, 1999; 19: 436-441
26. Auge N, Fitoussi G, Bascands JL, Pieraggi MT, Junquero D, Valet P, Girolami JP, Salvayre R, Negre-Salvayre A: Mildly oxidized LDL evokes a substained Ca (21) -dependent retraction of vascular smooth muscle cells. Circ Res, 1996; 79: 871-880
27. Zhao B, Ehringer WD, Dierichs R, Miller FN: Oxidized low-densitylipoprotein increases endothelial intracellular calcium and alters cytoskeletal f-actin distribution. Eur J Clin Invest, 1997; 27: 48-54
28. Takahashi R, Imamura A, Yoshikane M, Suzuki M, Murakami R, Cheng XW, Numaguchi Y, Ikeda N, Moruhara T, Okumura K: Very small low-density-lipoprotein cholesterol level is a determinant of arterial stiffness in men with impaired glucose metabolism. J Atheroscler Thromb, 2010; 17: 1282-1289