Comparative gene expression profiling of human umbilical vein endothelial cells and ocular vascular endothelial cells

British Journal of Ophthalmology

Volumn 96, Issue 1, 2012, Pages 128-132

  Browning, Andrew C ^a   Halligan, Eugene P ^b   Stewart, Elizabeth A ^a   Swan, Daniel C ^c   Dove, Rosamund ^d   Samaranayake, Govindi J ^a   Amoaku, Winfried M ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b ST THOMAS HOSPITAL   (United Kingdom)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

^d KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

SOMATOMEDIN C;

ADULT; ARTICLE; CELL ASSAY; CELL DIFFERENTIATION; CELL FUNCTION; CELLULAR IMMUNITY; CONTROLLED STUDY; FEMALE; GENE; GENE EXPRESSION PROFILING; GENE PROBE; HUMAN; HUMAN CELL; INSULIN LIKE GROWTH FACTOR 1 GENE; MALE; MICROVASCULAR ENDOTHELIAL CELL; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; SOMATIC CELL GENETICS; UMBILICAL VEIN ENDOTHELIAL CELL;

CAPILLARIES; CELL DIVISION; CHOROID; ENDOTHELIAL CELLS; GENE EXPRESSION PROFILING; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; IRIS; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; ORGAN CULTURE TECHNIQUES; ORGAN SPECIFICITY; REAL-TIME POLYMERASE CHAIN REACTION; RETINAL VESSELS;

EID: 84455194683     PISSN: 00071161     EISSN: 14682079     Source Type: Journal    
DOI: 10.1136/bjophthalmol-2011-300572     Document Type: Article

References (25)

1. 2+ in VEGF and FGF induced choroidal endothelial cell proliferation. Am J Physiol Cell Physiol 2001;281: C1448-56.
2. Brylla E, Tscheudschilsuren G, Santos AN, et al. Differences between retinal and choroidal microvascular endothelial cells (MVECs) under normal and hypoxic conditions. Exp Eye Res 2003;77:527-35. (Pubitemid 37188727)
3. Stahl A, Paschek L, Martin G, et al. Rapamycin reduces VEGF expression in retinal pigment epithelium (RPE) and inhibits RPE-induced sprouting angiogenesis in vitro. FEBS Lett 2008;582:3097-102.
4. Hamilton RD, Foss AJ, Leach L. Establishment of a human in vitro model of the outer blood retinal barrier. J Anat 2007;211:707-16. (Pubitemid 350182600)
5. Aird WC. Endothelial cell heterogeneity. Crit Care Med 2003;31(4 Suppl):S221-30. (Pubitemid 36458171)
6. Chi JT, Chang HY, Haraldsen G, et al. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A 2003;100:10623-8. (Pubitemid 37140079)
7. Thorin E, Shreeve SM. Heterogeneity of vascular endothelial cells in normal and disease states. Pharmacol Ther 1998;78:155-66. (Pubitemid 28255147)
8. Muller AM, Hermanns MI, Cronen C, et al. Comparative study of adhesion molecule expression in cultured human macro- and microvascular endothelial cells. Exp Mol Pathol 2002;73:171-80. (Pubitemid 38367364)
9. Browning AC, Gray T, Amoaku WM. The isolation and characterisation of human macular inner choroidal endothelial cells. Br J Ophthalmol 2005; 89:1343-7. (Pubitemid 41638878)
10. Browning AC, Dua HS, Amoaku WM. The effect of growth factors on the proliferation and in-vitro angiogenesis of human macular inner choroidal endothelial cells. Br J Ophthalmol 2008;92:1003-8. (Pubitemid 351969688)
11. Rymaszewski Z, Szymanski PT, Abplanalp WA, et al. Human retinal vascular cells differ from umbilical cells in synthetic functions and their response to glucose. Proc Soc Exp Biol Med 1992;199:183-91.
12. Silverman MD, Babra B, Pan Y, et al. Differential E-Selectin expression by iris versus retina microvascular endothelial cells cultured from the same individuals. Microvasc Res 2005;70:32-45.
13. Smith JR, Choi D, Chipps TJ, et al. Unique gene expression profiles of donor matched human retinal and choroidal vascular endothelial cells. Invest Ophthalmol Vis Sci 2007;48:2676-84. (Pubitemid 351261220)
14. Grisanti S, Heimann K, Wiedemann P. Immune response to specific molecules of the retina in proliferative vitreoretinal disorders. Graefes Arch Clin Exp Ophthalmol 1994;232:302-7. (Pubitemid 24164510)
15. Joussen AM, Murata T, Tsujikawa A, et al. Leukocyte mediated endothelial cell injury and death in the diabetic retina. Am J Pathol 2001;158:147-52. (Pubitemid 32096479)
16. Nussenblatt RB, Ferris F 3rd. Age-related macular degeneration and the immune response:implications for therapy. Am J Ophthalmol 2007;144:618-26.
17. Patel M, Chan CC. Immunopathological aspects of age-related macular degeneration. Semin Immunopathol 2008;30:97-110.
18. Lofqvist C, Willett KL, Aspergren O, et al. Quantification and localisation of the IGF/ insulin system expression in retinal blood vessels and neurons during oxygen induced retinopathy in mice. Invest Ophthalmol Vis Sci 2009;50:1831-7.
19. Poulaki V, Joussen AM, Mitsiades N, et al. Insulin-like growth factor-1 plays a pathogenic role in diabetic retinopathy. Am J Pathol 2004;165:457-69. (Pubitemid 38971376)
20. Wright AD, Kohner EM, Oakley NW, et al. Serum growth hormone levels and the response of diabetic retinopathy to pituitary ablation. BMJ 1969;2:346-8.
21. Smith LE, Shen W, Perruzzi C, et al. Regulation of vascular endothelial growth factor-dependent retinal neovascularisation by insulin-like growth factor-1 receptor. Nat Med 1999;5:1390-5.
22. Grant MB, Caballero S, Millard WJ. Inhibition of IGF-1 and b-FGF stimulated growth of human endothelial cells by the somatostatin analogue, octreotide: a potential treatment for ocular neovascularisation. Regul Pept 1993;48:267-78.
23. Ashcroft GS, Horan MA, Ferguson MW. Aging alters the inflammatory and endothelial cell adhesion molecule profiles during human cutaneous wound healing. Lab Invest 1998;78:47-58. (Pubitemid 28074308)
24. Donato AJ, Black AD, Jablonski KL, et al. Aging is associated with greater nuclear NFκ B, reduced IκBα and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy adults. Aging Cell 2008; 7:805-12. (Pubitemid 352749435)
25. Ishibashi K, Tian J, Handa JT. Similarity of mRNA phenotypes of morphologically normal macular and peripheral retinal pigment epithelial cells in older human eyes. Invest Ophthalmol Vis Sci 2004;45:3291-301. (Pubitemid 39121869)