In vitro studies on Bothrops venoms cytotoxic effect on tumor cells

Journal of Experimental Therapeutics and Oncology

Volumn 9, Issue 3, 2011, Pages 249-253

  Jorge, Roberta J B ^a   Martins, Alice M C ^a   Morais, Isabel C O ^a   Ximenes, Rafael M ^a   Rodrigues, Felipe A R ^a   Soares, Bruno M ^a   Evangelista, Janaina S A M ^b   Toyama, Marcos H ^c   Martins, Aline M A ^a   Moraes Filho, Manoel O ^a   Monteiro, Helena S A ^a  

^a FEDERAL UNIVERSITY OF CEARÁ   (Brazil)

^b Veterinary Faculty   (Brazil)

^c SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Apoptosis; Bothrops venoms; Citotoxicity; Flow citometry; Necrosis; Tumor cells

Indexed keywords

ANTINEOPLASTIC AGENT; BOTHROPS DIPORUS VENOM; BOTHROPS PAULOENSIS VENOM; BOTHROPS PIRAJAI VENOM; DOXORUBICIN; PHOSPHATIDYLSERINE; PROPIDIUM IODIDE; SNAKE VENOM; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BOTHROPS DIPORUS; BOTHROPS PAULOENSIS; BOTHROPS PIRAJAI; CELL DEATH; CELL DENSITY; CELL MEMBRANE; CONTROLLED STUDY; CYTOTOXICITY; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; SNAKE; TUMOR CELL;

ANIMALS; APOPTOSIS; BOTHROPS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; CROTALID VENOMS; FEMALE; HL-60 CELLS; HUMANS; NECROSIS; NERVOUS SYSTEM NEOPLASMS;

EID: 84455194050     PISSN: 13594117     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (19)

1. El-Refael MF, Sarkar NH. Snake venom inhibits the growth of mouse mammary tumor cells in vitro and in vivo. Toxicon 54: 33-41, 2009.
2. Calvete JJ, Sanz L, Angulo Y, Lomonte B, Gutiérrez JM. (2009). Venoms, venomics, antivenomics. FEBS Lett 583: 1736-1743, 2009.
3. Georgieva D, Arni RK, Betzel C. Proteome analysis of snake venom toxins: pharmacological insights. Expert Rev Proteomics 5: 87-797, 2008.
4. Gomes A, Bhattacharjee P, Mishra R, Biswas AK, Dasgupta SC, Giri B. Anticancer potential of animal venoms and toxins. Indian J Exp Biol 48: 93-103, 2010.
5. Heinen TE, Gorini da Veiga AB. Arthropod venoms and cancer. Toxicon 12: 1-15, 2011.
6. Daniele JJ, Bianco ID, Delgado C, Carrillo DB, Fidelio GD. A new phospholipase A2 isoform isolated from Bothrops neuwiedii (Yarará chica) venom with novel kinetic and chromatographic properties. Toxicon 35: 1205-1215, 1997. (Pubitemid 27326945)
7. Das Gupta S, Debnath A, Saha A, Giri B, Tripathi G, Vedasiromoni JR, Gomes A, Gomes A. Indian black scorpion (Heterometrus bengalensis Koch) venom induced antiproliferative and apoptogenic activity against human leukemic cell lines U937 and K562. Leuk Res 31: 817-825, 2007. (Pubitemid 46863378)
8. Newman RA, Vidal JC, Viskatis LJ, Johnson J, Etcheverry MA. VRCTC-310 a novel compound of purified animal toxins separates antitumour efficacy from neurotoxicity. Invest New Drugs 11: 151-159, 1993. (Pubitemid 23277235)
9. Costa LA, Miles H, Araujo CE, Gonzales S & Villarrubia VG. Tumour regression of advanced carcinomas following intra and/or peri tumoural inoculation with VRCTC-310 in human: preliminary report of two cases, Immunopharmacol Immunotoxocol 20: 15-25, 1998. (Pubitemid 28157288)
10. Mosman, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 65: 55-63, 1983.
11. Darzynkiewicz Z, Bruno S, Del Bino G, Gorczyca W, Hotz MA, Lassota P, Traganos F. Features of apoptotic cells measured by flow cytometry. Cytometry 13: 795-808, 1992.
12. Vermes C, Haanen H, Steffens-Nakken C. Reutelingsperger. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods 184: 39-51, 1995.
13. Roberto PG, Kashima S, Marcussi S, Pereira JO, Astolfi-Filho S, Nomizo A, Giglio JR, Fontes MR, Soares AM, Franca SC. Cloning and identification of a complete cDNA coding for a bactericidal and antitumoral acidic phospholipase A2 from Bothrops jararacussu venom. Protein J 23: 273-285, 2004. (Pubitemid 41399323)
14. Araya C, Lomonte B. Antitumor effects of cationic synthetic peptides derived from Lys49 phospholipase A2 homologues of snake venoms. Cell Biol Int 31: 263-268, 2007. (Pubitemid 46275481)
15. Costa TR, Menaldo DL, Oliveira CZ, Santos-Filho NA, Teixeira SS, Nomizo A, Fuly AL, Monteiro MC, de Souza BM, Palma MS, Stábeli RG, Sampaio SV & Soares AM. Myotoxic phospholipases A2 isolated from Bothrops brazili snake venom and synthetic peptides derived from their C-terminal region: Cytotoxic effect on microorganism and tumor cells. Peptides 29: 1645-1656, 2008.
16. Ricci MS, Zong WX. Chemotherapeutic approaches for targeting cell death pathways. Oncologist 11: 342-357, 2006.
17. Tolomeo M, Simoni D. Drug resistance and apoptosis in cancer treatment: development of new apoptosis-inducing agents active in drug resistant malignancies. Curr Med Chem Anticancer 2: 387-401, 2002. (Pubitemid 34649881)
18. Alves RM, Antonucci GA, Paiva HH, Cintra AC, Franco JJ, Mendonça-Franqueiro EP, Dorta DJ, Giglio JR, Rosa JC, Fuly AL, Dias-Baruffi M, Soares AM, Sampaio SV. Evidence of caspase-mediated apoptosis induced by L-amino acid oxidase isolated from Bothrops atrox snake venom. Comp Biochem Physiol A Mol Integr Physiol 151: 542-550, 2008.
19. Kallech-Ziri O, Luis J, El Ayeb M, Marrakchi N. Snake venom disintegrins: classification and therapeutic potential. Arch Inst Pasteur Tunis 84: 29-37, 2007.