Indian black scorpion (Heterometrus bengalensis Koch) venom induced antiproliferative and apoptogenic activity against human leukemic cell lines U937 and K562

Leukemia Research

Volumn 31, Issue 6, 2007, Pages 817-825

  Das Gupta, Shubho ^a   Debnath, Anindita ^a   Saha, Archita ^b   Giri, Biplab ^b   Tripathi, Gayatri ^a   Vedasiromoni, Joseph Rajan ^a   Gomes, Antony ^b   Gomes, Aparna ^a  

^a INDIAN INSTITUTE OF CHEMICAL BIOLOGY   (India)

^b UNIVERSITY OF CALCUTTA   (India)

Author keywords

Apoptosis; Cytotoxicity; Leukemic cell; Scorpion venom

Indexed keywords

DNA; SCORPION VENOM;

APOPTOSIS; ARTICLE; CELL CYCLE; CELL GROWTH; CELL PROLIFERATION; COMET ASSAY; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOTOXICITY; DNA CONTENT; DNA DEGRADATION; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GROWTH INHIBITION; HUMAN; HUMAN CELL; INDIA; LEUKEMIA CELL; NONHUMAN; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; SCORPION; TRADITIONAL MEDICINE;

ANIMALS; APOPTOSIS; CHROMATIN; DNA FRAGMENTATION; G1 PHASE; HUMANS; K562 CELLS; SCORPION VENOMS; U937 CELLS;

EID: 34249898393     PISSN: 01452126     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.leukres.2006.06.004     Document Type: Article

References (30)

1. Pal S.K., Gomes A., Dasgupta S.C., and Gomes A. Snake venom as therapeutic agents: from toxin to drug development. Indian J Exp Biol 40 (2002) 1353-1358
2. Wang R., Moreau P., Deschamps A., de Champlain J., Sauve R., Foucart S., et al. Cardiovascular effects of Buthus martensii (Karsch) scorpion venom. Toxicon 32 (1994) 191-200
3. Wang C.G., He X.L., Shao F., Liu W., Ling M.H., Wang D.C., et al. Molecular characterization of an anti-epilepsy peptide from the scorpion Buthus martensi Karsch. Eur J Biochem 268 (2001) 2480-2485
4. Torres-Larios A., Gurrola G.B., Zamudio F.Z., and Possani L.D. Hadrurin a new antimicrobial peptide from the venom of scorpion Hadrurus aztecus. Eur J Biochem 267 (2000) 5023-5031
5. Garcia M.L., Hanner M., Knaus H.G., Slaughter R., and Kaczorowski G.J. Scorpion toxins as tools for studying potassium channels. Meth Enzymol 294 (1999) 624-639
6. + channels. Eur J Biochem 245 (1997) 457-464
7. + channels. Structure-activity analysis using synthetic analogs. Int J Pept Protein Res 43 (1994) 486-495
8. Strong P.N., Clark G.S., Arumugam A., De-Allie F.A., Joseph J.S., Yemul V., et al. Tamulustoxin: a novel potassium channel blocker from the venom of the Indian red scorpion Mesobuthus tamulus. Arch Biochem Biophys 385 (2001) 138-144
9. +) channel activity in human prostrate cancer cell lines of markedly different metastatic potential: distinguishing characteristics of PC-3 and LNCaP cells. Prostrate 46 (2001) 262-274
10. Gallagher J.D., Fay M.J., North W.G., and McCann F.V. Ionic signals in T47D human breast cancer cells. Cell Signal 8 (1996) 279-284
11. Wang W.X., and Ji Y.H. Scorpion venom induces glioma cell apoptosis in vivo and inhibits glioma tumor growth in vitro. J Neurooncol 73 (2005) 1-7
12. Soroceanu L., Gillespie Y., Khazaeli M.B., and Sontheimer H. Use of Chlorotoxin for targeting of primary brain tumors. Cancer Res 58 (1998) 4871-4879
13. Tikadar B.K., and Bastwade D.B. The fauna of India. Scorpions, scorpionida: arachnida vol. III (1983), Zoological Survey of India, Calcutta
14. Lahiri S.C., and Chaudhuri A.K. Action of the scorpion (Heterometrus bengalensis C.L. Koch) venom on smooth muscle. Indian J Exp Biol 20 (1982) 545-548
15. Kar P.K., Sarangi B., Datta A., Gomes A., and Lahiri S.C. Separation and partial characterization of smooth muscle contractile material in the venom of the scorpion Heterometrus bengalensis. Toxicon 21 (1983) 353-361
16. Kar P.K., Sarangi B., Datta A., Gomes A., and Lahiri S.C. Occurrence of phospholipase in the venom of the scorpion (Heterometrus bengalensis). Indian J Med Res 83 (1986) 332-337
17. Lahiri S.C., and Nag Chowdhury A.K. Release of kinin by the scorpion (Heterometrus bengalensis C.L. Koch) venom. Indian J Exp Biol 21 (1983) 198-202
18. Cao Z., and Li Y. Chemical induction of cellular antioxidants affords marked protection against oxidative injury in vascular smooth muscle cells. Biochem Biophys Res Commun 292 (2002) 50-57
19. Muench H., and Reed L.J. A simple method of estimating 50 per cent end points. Am J Hyg 27 (1938) 493-497
20. Grujic M., Zavasnik-Bergant T., Pejler G., and Renko M. Actinonin induces apoptosis in U937 leukemia cells. Cancer Lett 223 (2005) 211-218
21. Nottola S.A., Makabe S., Stallone T., Familiari G., Correr S., and Macchiarelli G. Surface morphology of the zona pellucida surrounding human blastocysts obtained after in vitro fertilization. Arch Histol Cytol 68 (2005) 133-141
22. Singh N.P., McCoy M.T., Tice R.R., and Schneider E.L. A simple technique for quantitation of low levels of DNA damage in individual cells. Exp Cell Res 175 (1988) 184-191
23. Vermes I., Haanen C., Steffens-Nakken H., and Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled annexin V. J Immunol Meth 184 (1995) 39-51
24. Surh Y.J., Hurh Y.J., Kang J.Y., Lee E., Kong G., and Lee S.J. Resveratrol an antioxidant present in red wine, induces apoptosis in human promyelocytic leukemia (HL-60) cells. Cancer Lett 140 (1999) 1-10
25. + ion channel blockers. J Neurosci 19 (1999) 5942-5954
26. Chinkwo K.A. Sutherlandia frutescens extracts can induce apoptosis in cultured carcinoma cells. J Ethnopharmacol 98 (2005) 163-170
27. Darzynkiewicz Z., Juan G., Li X., Gorczyca W., Murakami T., and Traganos F. Cytometry in cell necrobiology: analysis of apoptosis and accidental cell death (necrosis). Cytometry 27 (1997) 1-20
28. Belloc F., Dumain P., Boisseau M.R., Jalloustre C., Reiffers J., Bernard P., et al. A flow cytometric method using Hoechst 33342 & propidium iodide for simultaneous cell cycle analysis and apoptosis determination in unfixed cells. Cytometry 17 (1994) 59-65
29. Darzynkiewicz Z., Bedner E., and Smolewski P. Flow cytometry in analysis of cell cycle and apoptosis. Semin Hematol 38 (2001) 179-193
30. Wising C., Azem J., Zetterberg M., Svensson L.A., Ahlman K., and Lagergard T. Induction of apoptosis/necrosis in various human cell lineage by Haemophilus ducreyi cytolethal distending toxin. Toxicon 45 (2005) 767-776