5-HT 1A receptor activation improves anti-cataleptic effects of levodopa in 6-hydroxydopamine-lesioned rats

DARU, Journal of Pharmaceutical Sciences

Volumn 19, Issue 5, 2011, Pages 338-343

  Mahmoudi, J ^a   Mohajjel Nayebi, A ^b   Samini, M ^a   Reyhani Rad, S ^c   Babapour, V ^a  

^a ISLAMIC AZAD UNIVERSITY   (Iran)

^b TABRIZ UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c ISLAMIC AZAD UNIVERSITY   (Iran)

Author keywords

5 HT 1A receptor; 8 OHDAPT; Catalepsy; L DOPA

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; LEVODOPA; OXIDOPAMINE; SEROTONIN 1A RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFICACY; EXPERIMENTAL DESIGN; MALE; NONHUMAN; PARKINSON DISEASE; RAT; RESPONSE TIME; WISTAR RAT;

EID: 84455188826     PISSN: 15608115     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (23)

1. Kalda A, Herm L, Rinken A, Zharkovsky A, Chen JF. Co-administration of the partial dopamine D2 agonist terguride with L-DOPA attenuates L-DOPA-induced locomotor sensitization in hemiparkinsonian mice. Behav Brain Res, 2009; 202: 232-237.
2. Tomiyama M, Kimura T, Maeda T, Kannari K, Matsunaga M, Baba M. A serotonin 5HT1A receptor agonist prevents behavioral sensitization to L-DOPA in rodent model of Parkinson's disease. Neuroscience Reaserch, 2005; 52: 185-194.
3. Cenci MA, Lundblad M: Post-versus presynaptic plasticity in L-DOPA-induced dyskinesia. J Neurochem, 2006; 99: 381-392.
4. Maeda T, Kannari K, Huo S, Arai A, Tomiyama M, Matsunaga M, Suda T: Increase of the striatal serotonergic fibers after nigrostriatal dopaminergic denervation in adult rats. International Congress Series, 2003; 1251: 211-215.
5. Carlsson T, Carta M, Winkler C, Björklund A, Kirik D. Serotonin Neuron Transplants Exacerbate L-DOPAInduced Dyskinesias in a Rat Model of Parkinson's Disease. J Neurosci, 2007; 27: 8011-8022.
6. Carta M, Carlsson T, Kirik D, Björklund A. Dopamine released from 5-HT terminals is the causeof L-DOPA-induced dyskinesia in parkinsonian rats. Brain, 2007; 130: 1819-1833.
7. Carta M, Carlsson T, Muñoz A, Kirik D, Björklund A. Involvement of the serotonin system in L-DOPA-induced dyskinesias. Parkinsonism Relat Disord, 2008; 14: 154-158.
8. 1B receptors. J Pharmacol Exp Ther, 2000; 292:1111-1117.
9. Ichikawa J, Meltzer HY. R(+)-8-OH-DPAT, a serotonin1A receptor agonist, potentiated S(-)-sulpirideinduced dopamine release in rat medial prefrontal cortex and nucleus accumbens but not striatum. J Pharmacol Exp Ther, 1999; 291:1227-1232.
10. Harrington MA, Oksenberg D, Peroutka SJ. 5-Hydroxytryptamine1A receptors are linked to a Gi-adenylate cyclase complex in rat hippocampus. Eur J Pharmacol; 1988, 154: 95-98.
11. Nayebi AM, Rad SR, Saberian M, Azimzadeh S, Samini M. Buspirone improves 6-hydroxydopamine- induced catalepsy through stimulation of 5-HT1A receptors in rats. Pharmacol Rep, 2010; 62: 258-264.
12. 1B receptors. DARU, 2010; 18: 41-45.
13. Bara-Jimenez W, Bibbiani F, Morris MJ, Dimitrova T, Sherzai A, Mouradian MM, Chase TN. Effects of Serotonin 5-HT1A Agonist in Advanced Parkinson's Disease. Mov Disord, 2005; 20: 932-936.
14. Paxinos G, Watson C. The rat brain in stereotaxic coordinates. Academic press, Sydney, 1982.
15. De la Fuente-Fernández R, Schulzer M, Mak E, Calne DB, Stoessl AJ. Presynaptic mechanisms of motor fluctuations in Parkinson's disease: a probabilistic model. Brain, 2004; 127: 888-899.
16. Yu JG, Wu J, Shen FM, Cai GJ, Liu JG, Su DF. Arterial baroreflex dysfunction fails to mimic Parkinson's disease in rats. J Pharmacol Sci, 2008; 108: 56-62.
17. Eskow KL, Gupta V, Alam S, Park JY, Bishop C. The partial 5-HT1A agonist buspirone reduces the expression and development of L-DOPA-induced dyskinesia in rats and improves L-DOPA efficacy. Pharmacol Biochem Behav, 2007; 87: 306-314.
18. Carlsson T, Carta M, Winkler C, Björklund A, Kirik D. Serotonin neuron transplants exacerbate L-DOPA Induced dyskinesias in a rat model of Parkinson's disease. J Neurosci, 2007; 27: 8011-8022.
19. Nayebi AM. Hypothesis: A promising effect of 5-HT1A receptor agonists in alleviating motor symptoms of Parkinson's disease. AJPP, 2010; 4: 289-290.
20. Carta M, Carlsson T, Muñoz A, Kirik D, Björklund A. Serotonin-dopamine interaction in induction and maintenance of L-DOPA-induced dyskinesias. Prog Brain Res, 2008; 172: 465-478.
21. Bibbiani F, Oh JD, Chase TN. Serotonin 5-HT1A agonist improves motor complications in rodent and primate parkinsonian models. Neurology, 2001; 57:1829-1834.
22. 1A and 5-HT7 receptors to induce hypothermia in rodents. Eur J Pharmacol, 2004; 487: 125-132.
23. 1A receptors in alleviating antipsychotic-induced extrapyramidal disorders. Prog Neuropsychopharmacol Biol Psychiatry, 2010; 34: 877-881.