Effects on small airway obstruction of long-term treatments with beclomethasone/formoterol hydrofluoroalkane (metered-dose inhaler) versus fluticasone/salmeterol (dry-powder inhaler) in asthma: A preliminary study

Allergy and Asthma Proceedings

Volumn 32, Issue 6, 2011, Pages

  Corda, Luciano ^a   Gardenghi, Giovanni Gardini ^b   Modina, Denise ^b   Montemurro, Luigi Taranto ^b   Novali, Mauro ^b   Tantucci, Claudio ^b  

^a SPEDALI CIVILI   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; BECLOMETASONE PLUS FORMOTEROL; FLUORINATED HYDROCARBON; FLUTICASONE PROPIONATE PLUS SALMETEROL; FORMOTEROL; HELIOX; UNCLASSIFIED DRUG;

ADULT; AIR; AIRWAY OBSTRUCTION; ARTICLE; ASTHMA; ASTHMA CONTROL TEST; CLINICAL ARTICLE; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG FORMULATION; FEMALE; FORCED EXPIRATORY VOLUME; FORCED VITAL CAPACITY; HUMAN; LONG TERM CARE; LUNG FUNCTION TEST; MALE; MAXIMAL EXPIRATORY FLOW; METERED DOSE INHALER; PATIENT COMPLIANCE; POWDER INHALER; QUESTIONNAIRE; RANDOMIZED CONTROLLED TRIAL; RESPIRATORY TRACT PARAMETERS; TREATMENT OUTCOME;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ADULT; AIRWAY OBSTRUCTION; ALBUTEROL; ANDROSTADIENES; ANTI-ASTHMATIC AGENTS; ASTHMA; BECLOMETHASONE; DRUG COMBINATIONS; DRY POWDER INHALERS; ETHANOLAMINES; FEMALE; HUMANS; HYDROCARBONS, FLUORINATED; MALE; METERED DOSE INHALERS; MIDDLE AGED; RESPIRATORY FUNCTION TESTS; TREATMENT OUTCOME;

EID: 84455188456     PISSN: 10885412     EISSN: 15396304     Source Type: Journal    
DOI: 10.2500/aap.2011.32.3477     Document Type: Article

References (21)

1. Hamid Q, Song Y, Kotsimbos TC, et al. Inflammation of small airways in asthma. J Allergy Clin Immunol 100:44, 1997.
2. Van Vyve T, Chanez P, Lacoste JY, et al. Comparison between bronchial and alveolar samples of bronchoalveolar lavage fluid in asthma. Chest 102:356-361, 1992.
3. Carrol N, Elliot J, Morton A, and James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 147:405- 410, 1993.
4. Kraft M, Djukanovic R, Wilson S, et al. Alveolar tissue inflammation in asthma. Am J Respir Crit Care Med 154:1505-1510, 1996. (Pubitemid 26391205)
5. Saetta M, Di Stefano A, Rosina C, et al. Quantitative structural analysis of peripheral airways and arteries in sudden fatal asthma. Am Rev Respir Dis 143:138-143, 1991.
6. Global Initiative for Asthma. Global strategy for asthma management and prevention. National Institute of Health (NIH), National Heart Lung and Blood Institute (NHLBI), NHLBI/ WHO Workshop Report 02-3659, Bethesda, MD, January 1995, updated 2006.
7. Wilson JW, Djukanovic R, Howarth PH, and Holgate ST. Inhaled beclomethasone dipropionate downregulates airway lymphocyte activation in atopic asthma. Am J Respir Crit Care Med 149:86-90, 1994. (Pubitemid 24066101)
8. Djukanovic R, Wilson JW, Britten KM, et al. Effects of an inhaled corticosteroid an airway inflammation and symptoms in asthma. Am Rev Respir Dis 145:669-674, 1992.
9. Leach CL, Davidson PJ, and Boudreau RJ. Improved airway targeting with the CFC-free HFA-beclomethasone metereddose inhaler compared with CFC-beclomethasone. Eur Respir J 12:1346-1353, 1998. (Pubitemid 29011427)
10. Van Schayck CP, and Donnel D. The efficacy and safety of QVAR (hydrofluoroalkane-beclomethasone dipropionate extrafine aerosol) in asthma (Part1): An update of clinical experience in adults. Int J Clin Pract 58:678-688, 2004. (Pubitemid 39144583)
11. Papi A, Paggiaro L, Nicolini G, et al. Beclomethasone/formoterol versus budesonide/formoterol combination therapy in asthma. Eur Respir J 29:682-689, 2007. (Pubitemid 46554617)
12. Papi A, Paggiaro L, Nicolini G, et al. Beclomethasone/formoterol vs fluticasone/salmeterol inhaled combination in moderate to severe asthma. Allergy 62:1182-1188, 2007. (Pubitemid 47374029)
13. Nathan RA, Sorkness CA, Kosinski M, et al. Development of the Asthma Control Test: A survey for assessing asthma control. J Allergy Clin Immunol 113:59-65, 2004. (Pubitemid 38096162)
14. American Thoracic Society: Standardization of spirometry: 1994 update. Am J Respir Crit Care Med 152:1107, 1995.
15. Milic-Emili J, Torchio R, and D'Angelo E. Closing volume: A reappraisal (1967-2007). Eur J Appl Physiol 99:567-583, 2007. (Pubitemid 46404015)
16. Scichilone N, Battaglia S, Sorino C, et al. Effects of extra-fine inhaled beclomethasone/formoterol on both large and small airways in asthma. Allergy 65:897-902, 2010.
17. Nicolini G, Chetta A, Simonazzi A, et al. Both bronchial and alveolar exhaled nitric oxide are reduced with extrafine beclomethasone dipropionate in asthma. Allergy Asthma Proc 31:85-90, 2010.
18. Nelson HS, Gallegos CM, Silveira LJ, et al. Effect of the inhaled corticosteroid mometasone on small airway patency in patients with asthma. Allergy Asthma Proc 30:284 -292, 2009.
19. in't Veen J, Beekman AJ, Bel E, and Sterk P. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 161:1902-1906, 2000.
20. Downie SR, Salome CM, Verbank S, et al. Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax 62:684-689, 2007. (Pubitemid 47235010)
21. Yamaguchi M, Niimi A, Ueda T, et al. Effect on inhaled corticosteroids on small airways in asthma: Investigation using impulse oscillometry. Pulm Pharmacol Ther 22:326 -332, 2009.