Follicle-stimulating hormone is independently associated with lean mass but not BMD in younger postmenopausal women

Bone

Volumn 50, Issue 1, 2012, Pages 311-316

  Gourlay, Margaret L ^a   Specker, Bonny L ^b   Li, Chenxi ^c   Hammett Stabler, Catherine A ^a   Renner, Jordan B ^a   Rubin, Janet E ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b SOUTH DAKOTA STATE UNIVERSITY   (United States)

^c IL   (United States)

Author keywords

Body composition; Bone densitometry; Bone mineral density; Bone QCT; Follicle stimulating hormone; Menopausal

Indexed keywords

25 HYDROXYVITAMIN D; ALKALINE PHOSPHATASE BONE ISOENZYME; AMINO TERMINAL TELOPEPTIDE; ESTRADIOL; FOLLITROPIN; LUTEINIZING HORMONE; PARATHYROID HORMONE; PRASTERONE SULFATE; SEX HORMONE; SEX HORMONE BINDING PROTEIN;

ADULT; ARTICLE; BODY COMPOSITION; BONE DENSITOMETRY; BONE DENSITY; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DUAL ENERGY X RAY ABSORPTIOMETRY; FEMALE; FEMUR NECK; HIP; HUMAN; LEAN BODY WEIGHT; OSTEOPOROSIS; POSTMENOPAUSE; QUANTITATIVE ANALYSIS; RADIUS; RISK FACTOR; SENSITIVITY ANALYSIS; SPINE;

ABSORPTIOMETRY, PHOTON; ANIMALS; ANTHROPOMETRY; BODY COMPOSITION; BODY MASS INDEX; BONE AND BONES; BONE DENSITY; CROSS-SECTIONAL STUDIES; FEMALE; FOLLICLE STIMULATING HORMONE, HUMAN; HUMANS; MIDDLE AGED; POSTMENOPAUSE;

EID: 84455179874     PISSN: 87563282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bone.2011.11.001     Document Type: Article

References (30)

1. Sun L., Peng Y., Sharrow A., Iqbal J., Zhang Z., Papachristou D., et al. FSH directly regulates bone mass. Cell 2006, 125:247-260.
2. Gao J., Tiwari-Pandey R., Samadfam R., Yang Y., Miao D., Karaplis A., et al. Altered ovarian function affects skeletal homeostasis independent of the action of follicle-stimulating hormone. Endocrinology 2007, 148:2613-2621.
3. Drake M.T., McCready L.K., Hoey K.A., Atkinson E.J., Khosla S. Effects of suppression of follicle-stimulating hormone secretion on bone resorption markers in postmenopausal women. J Clin Endocrinol Metab 2010, 95:5063-5068.
4. Gourlay M.L., Preisser J.S., Hammett-Stabler C.A., Renner J.B., Rubin J. Follicle-stimulating hormone and bioavailable estradiol are less important than weight and race in determining bone density in younger postmenopausal women. Osteoporos Int 2011, 22:2699-2708.
5. De Pergola G., Maldera S., Tartagni M., Pannacciulli N., Loverro G., Giorgino R. Inhibitory effect of obesity on gonadotropin, estradiol, and inhibin B levels in fertile women. Obesity (Silver Spring) 2006, 14:1954-1960.
6. Sowers M., Zheng H., Tomey K., Karvonen-Gutierrez C., Jannausch M., Li X., et al. Changes in body composition in women over six years at midlife: ovarian and chronological aging. J Clin Endocrinol Metab 2007, 92:895-901.
7. Cannon J.G., Cortez-Cooper M., Meaders E., Stallings J., Haddow S., Kraj B., et al. Follicle-stimulating hormone, interleukin-1, and bone density in adult women. Am J Physiol Regul Integr Comp Physiol 2010, 298:R790-R798.
8. Pluijm S.M., Visser M., Smit J.H., Popp-Snijders C., Roos J.C., Lips P. Determinants of bone mineral density in older men and women: body composition as mediator. J Bone Miner Res 2001, 16:2142-2151.
9. Douchi T., Yamamoto S., Oki T., Maruta K., Kuwahata R., Yamasaki H., et al. Difference in the effect of adiposity on bone density between pre- and postmenopausal women. Maturitas 2000, 34:261-266.
10. Aloia J.F., Vaswani A., Ma R., Flaster E. To what extent is bone mass determined by fat-free or fat mass?. Am J Clin Nutr 1995, 61:1110-1114.
11. Gnudi S., Sitta E., Fiumi N. Relationship between body composition and bone mineral density in women with and without osteoporosis: relative contribution of lean and fat mass. J Bone Miner Metab 2007, 25:326-332.
12. Compston J.E., Bhambhani M., Laskey M.A., Murphy S., Khaw K.T. Body composition and bone mass in post-menopausal women. Clin Endocrinol (Oxf) 1992, 37:426-431.
13. Khosla S., Melton L., Atkinson E., O'Fallon W., Klee G., Riggs B. Relationship of serum sex steroid levels and bone turnover markers with bone mineral density in men and women: a key role for bioavailable estrogen. J Clin Endocrinol Metab 1998, 83:2266-2274.
14. StataCorp. Stata Statistical Software: Release SE 9.2 2005, College Station.
15. Bland J., Altman D. Multiple significance tests: the Bonferroni method. BMJ 1995, 310:170.
16. Khosla S., Riggs B., Robb R., Camp J., Achenbach S., Oberg A., et al. Relationship of volumetric bone density and structural parameters at different skeletal sites to sex steroid levels in women. J Clin Endocrinol Metab 2005, 90:5096-5103.
17. Allan C.M., Kalak R., Dunstan C.R., McTavish K.J., Zhou H., Handelsman D.J., et al. Follicle-stimulating hormone increases bone mass in female mice. Proc Natl Acad Sci U S A 2010, 107:22629-22634.
18. Hulens M., Vansant G., Lysens R., Claessens A.L., Muls E., Brumagne S. Study of differences in peripheral muscle strength of lean versus obese women: an allometric approach. Int J Obes Relat Metab Disord 2001, 25:676-681.
19. Chaki O., Yoshikata I., Kikuchi R., Nakayama M., Uchiyama Y., Hirahara F., et al. The predictive value of biochemical markers of bone turnover for bone mineral density in postmenopausal Japanese women. J Bone Miner Res 2000, 15:1537-1544.
20. Gorai I., Taguchi Y., Chaki O., Nakayama M., Minaguchi H. Specific changes of urinary excretion of cross-linked N-telopeptides of type I collagen in pre- and postmenopausal women: correlation with other markers of bone turnover. Calcif Tissue Int 1997, 60:317-322.
21. Tremblay M.S., Chu S.Y., Mureika R. Methodological and statistical considerations for exercise-related hormone evaluations. Sports Med 1995, 20:90-108.
22. Fewell Z., Davey Smith G., Sterne J.A. The impact of residual and unmeasured confounding in epidemiologic studies: a simulation study. Am J Epidemiol 2007, 166:646-655.
23. Villareal D.T., Chode S., Parimi N., Sinacore D.R., Hilton T., Armamento-Villareal R., et al. Weight loss, exercise, or both and physical function in obese older adults. N Engl J Med 2011, 364:1218-1229.
24. Wildner M., Peters A., Raghuvanshi V., Hohnloser J., Siebert U. Superiority of age and weight as variables in predicting osteoporosis in postmenopausal white women. Osteoporos Int 2003, 14:950-956.
25. Zhai G., Hart D., Valdes A., Kato B., Richards J., Hakim A., et al. Natural history and risk factors for bone loss in postmenopausal Caucasian women: a 15-year follow-up population-based study. Osteoporos Int 2008, 19:1211-1217.
26. Koh L., Ben Sedrine W., Torralba T., Kung A., Fujiwara S., Chan S., et al. A simiple tool to identify Asian women at increased risk of osteoporosis. Osteoporos Int 2001, 12:699-705.
27. Waugh E., Lam M., Hawker G., McGowan J., Papaioannou A., Cheung A., et al. Risk factors for low bone mass in healthy 40-60 year old women: a systematic review of the literature. Osteoporos Int 2009, 10:1-21.
28. Macdonald H., New S., Campbell M., Reid D. Influence of weight and weight change on bone loss in perimenopausal and early postmenopausal Scottish women. Osteoporos Int 2005, 16:163-171.
29. May H., Murphy S., Khaw K.-T. Age-associated bone loss in men and women and its relationship to weight. Age and Aging 1994, 23:235-240.
30. Harris S., Dallal G., Dawson-Hughes B. Influence of body weight on rates of change in bone density of the spine, hip, and radius in postmenopausal women. Calcif Tissue Int 1992, 50:19-23.