The vitamin K-dependent carboxylase generates γ-carboxylated glutamates by using CO 2to facilitate glutamate deprotonation in a concerted mechanism that drives catalysis

Journal of Biological Chemistry

Volumn 286, Issue 52, 2011, Pages 44821-44832

  Rishavy, Mark A ^a   Hallgren, Kevin W ^a   Berkner, Kathleen L ^a  

^a LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CONCERTED MECHANISM; ELECTROPHILES; HIGH ENERGY; KINETIC PROPERTIES; NEGATIVE CHARGE; REPROTONATION; TRITIUM RELEASE; WILD-TYPE ENZYMES;

CARBOXYLATION; CATALYSIS; CYANIDES; DEPROTONATION; ENZYMES; IONS; PROTEINS; TRITIUM;

CARBON DIOXIDE;

ANION; CARBANION; CARBON DIOXIDE; CYANIDE; ELECTROPHILE; GAMMA CARBOXYLATED GLUTAMATE; GLUTAMIC ACID; TRITIUM; UNCLASSIFIED DRUG; VITAMIN K DEPENDENT CARBOXYLASE; WATER;

ARTICLE; CARBOXYLATION; CATALYSIS; CATION TRANSPORT; CONTROLLED STUDY; DEPROTONATION; EPOXIDATION; MICROSOME; PRIORITY JOURNAL;

AMINO ACID SUBSTITUTION; ANIMALS; CARBON DIOXIDE; CARBON-CARBON LIGASES; CATALYSIS; CELL LINE; GLUTAMIC ACID; MUTATION, MISSENSE;

EID: 84455161786     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.249177     Document Type: Article

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